Finding the Right Match Fast

Cell 160(5):809 (2015)

DNA recombinases face the daunting task of locating and pairing up specific sequences among millions of base pairs in a genome, all within about an hour. Qi et al. show that recombinases solve this problem by searching in 8-nt microhomology units, reducing the search space and accelerating the homology search.

DOI: 10.1016/j.cell.2015.02.007