Treatment of Ebola

New England Journal of Medicine 372(17):1673 (2015) PMID 25901439

To the Editor: We were struck by the similarity of transient vascular leak in Ebola virus disease (EVD), as reported by Lyon et al. (Dec. 18 issue),1 with that which occurs in dengue. When severe dengue was first described, uncorrected hypovolemia often led to shock, hemorrhage, and death.2 A study involving children with dengue showed that fluid loss from the vascular compartment was indicated by a 20% increase in packed-cell volume.3 Pulse pressure was determined to be the most clinically significant marker of the severity of leakage.4 Frequent hematocrit and blood-pressure monitoring are essential in correcting plasma leakage while preventing . . .

DOI: 10.1056/NEJMc1500452