1. Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures.

    Stem Cells and Development 24(23):2778 (2015) PMID 26283078 PMCID PMC4653822

    Stem cell-based therapy of retinal degenerative conditions is a promising modality to treat blindness, but requires new strategies to improve the number of functionally integrating cells. Grafting semidifferentiated retinal tissue rather than progenitors allows preservation of tissue structure a...
  2. All spiking, sustained ON displaced amacrine cells receive gap-junction input from melanopsin ganglion cells.

    Current Biology 25(21):2763 (2015) PMID 26441349 PMCID PMC4631663

    Retinal neurons exhibit sustained versus transient light responses, which are thought to encode low- and high-frequency stimuli, respectively. This dichotomy has been recognized since the earliest intracellular recordings from the 1960s, but the underlying mechanisms are not yet fully understood...
  3. Characterizing and modeling the intrinsic light response of rat ganglion-cell photoreceptors.

    Journal of Neurophysiology 114(5):2955 (2015) PMID 26400257 PMCID PMC4737408

    Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate both image-forming vision and non-image-forming visual responses such as pupillary constriction and circadian photoentrainment. Five types of ipRGCs, named M1-M5, have been discovered in rodents. To further investigate their ph...
  4. The rat retina has five types of ganglion-cell photoreceptors.

    Experimental Eye Research 130:17 (2015) PMID 25450063 PMCID PMC4276437

    Intrinsically photosensitive retinal ganglion cells (ipRGCs) are inner retinal photoreceptors that mediate non-image-forming visual functions, e.g. pupillary constriction, regulation of pineal melatonin release, and circadian photoentrainment. Five types of ipRGCs were recently discovered in mou...