1. The Combination of ISCOMATRIX Adjuvant and TLR Agonists Induces Regression of Established Solid Tumors In Vivo.

    Journal of Immunology 194(5):2199 (2015) PMID 25646304

    The development of therapeutic vaccines for treatment of established cancer has proven challenging. Cancer vaccines not only need to induce a robust tumor Ag-specific immune response but also need to overcome the tolerogenic and immunosuppressive microenvironments that exist within many solid ca...
  2. The Combination of ISCOMATRIX Adjuvant and TLR Agonists Induces Regression of Established Solid Tumors In Vivo.

    Journal of Immunology 194(5):2199 (2015) PMID 25646304

    The development of therapeutic vaccines for treatment of established cancer has proven challenging. Cancer vaccines not only need to induce a robust tumor Ag-specific immune response but also need to overcome the tolerogenic and immunosuppressive microenvironments that exist within many solid ca...
  3. Combination of adjuvants: the future of vaccine design.

    Expert Review of Vaccines 12(7):733 (2013) PMID 23885819

    It is thought that the development of vaccines for the treatment of infectious diseases and cancer is likely to be achieved in the coming decades. This is partially due to a better understanding of the regulatory networks connecting innate with adaptive immune responses. The innate immune respon...
  4. Combination of adjuvants: the future of vaccine design.

    Expert Review of Vaccines 12(7):733 (2013) PMID 23885819

    It is thought that the development of vaccines for the treatment of infectious diseases and cancer is likely to be achieved in the coming decades. This is partially due to a better understanding of the regulatory networks connecting innate with adaptive immune responses. The innate immune respon...
  5. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

    Journal of Experimental Medicine 209(11):2049 (2012) PMID 23045607 PMCID PMC3478936

    A strong humoral response to infection requires the collaboration of several hematopoietic cell types that communicate via antigen presentation, surface coreceptors and their ligands, and secreted factors. The proinflammatory cytokine IL-6 has been shown to promote the differentiation of activat...
  6. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

    Journal of Experimental Medicine 209(11):2049 (2012) PMID 23045607 PMCID PMC3478936

    A strong humoral response to infection requires the collaboration of several hematopoietic cell types that communicate via antigen presentation, surface coreceptors and their ligands, and secreted factors. The proinflammatory cytokine IL-6 has been shown to promote the differentiation of activat...
  7. Bid and Bim collaborate during induction of T cell death in persistent infection.

    Journal of Immunology 186(7):4059 (2011) PMID 21339359 PMCID PMC3159036

    Upon Ag encounter, naive T cells undergo extensive Ag-driven proliferation and can differentiate into effector cells. Up to 95% of these cells die leaving a small residual population of T cells that provide protective memory. In this study, we investigated the contribution of the BH3-only family...
  8. Bid and Bim collaborate during induction of T cell death in persistent infection.

    Journal of Immunology 186(7):4059 (2011) PMID 21339359 PMCID PMC3159036

    Upon Ag encounter, naive T cells undergo extensive Ag-driven proliferation and can differentiate into effector cells. Up to 95% of these cells die leaving a small residual population of T cells that provide protective memory. In this study, we investigated the contribution of the BH3-only family...
  9. Dendritic cells in viral infections.

    Handbook of experimental pharmacology (188):51 (2009) PMID 19031021

    Antigen presenting cells (APCs) are recognized as key initiators of adaptive immunity, particularly to pathogens, by eliciting a rapid and potent immune attack on infected cells. Amongst APCs, dendritic cells (DCs) are specially equipped to initiate and regulate immune responses in a manner that...
  10. Dendritic cells in viral infections.

    Handbook of experimental pharmacology (188):51 (2009) PMID 19031021

    Antigen presenting cells (APCs) are recognized as key initiators of adaptive immunity, particularly to pathogens, by eliciting a rapid and potent immune attack on infected cells. Amongst APCs, dendritic cells (DCs) are specially equipped to initiate and regulate immune responses in a manner that...
  11. Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection.

    Journal of Immunology 179(11):7506 (2007) PMID 18025195

    The activation and maintenance of Ag-specific CD8(+) T cells is central to the long-term control of persistent infections. These killer T cells act to continuously scan and remove reservoirs of pathogen that have eluded the acute immune response. Acutely cleared viral infections depend almost ex...
  12. Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection.

    Journal of Immunology 179(11):7506 (2007) PMID 18025195

    The activation and maintenance of Ag-specific CD8(+) T cells is central to the long-term control of persistent infections. These killer T cells act to continuously scan and remove reservoirs of pathogen that have eluded the acute immune response. Acutely cleared viral infections depend almost ex...
  13. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...
  14. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...
  15. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.

    Nature Immunology 7(2):165 (2006) PMID 16415871

    The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited c...
  16. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.

    Nature Immunology 7(2):165 (2006) PMID 16415871

    The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited c...