1. Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; identification of hits for visceral leishmaniasis and Chagas disease.

    Molecules 14(1):279 (2009) PMID 19136916

    There is an urgent need for novel and improved drugs against several tropical diseases caused by protozoa. The marine sponge (Agelas sp.) metabolite agelasine D, as well as other agelasine analogs and related structures were screened for inhibitory activity against Plasmodium falciparum, Leishma...
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  2. The first synthesis ofent-agelasine F

    Tetrahedron 65(1):194 (2009)

    Agelasine F has previously been isolated from marine sponges ( Agelas sp.) and has been associated with various bioactivities including inhibitory activity on Mycobacterium tuberculosis. No total synthesis of this natural product has been reported. ent-Agelasine F has no...
  3. Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a beta-cyclocitral derived substituent.

    Archiv der Pharmazie (Weinheim) 340(12):625 (2007) PMID 17994607

    Agelasines and agelasimines are antimicrobial and cytotoxic purine derivatives isolated from marine sponges (Agelas sp.). We have synthesized structurally simplified analogs of these natural products starting from beta-cyclocitral. The novel compounds were found to be strong inhibitors of a wide...
  4. Oxamides as novel NR2B selective NMDA receptor antagonists.

    Bioorganic & Medicinal Chemistry Letters 14(15):3953 (2004) PMID 15225705

    A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
  5. Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts

    Applied Catalysis A: General 269(1):249 (2004)

    The heterogeneous catalytic hydrogenation of 4-(4-fluorobenzyl)pyridine resulted in 4-(4-fluorobenzyl)piperidine, an important and valuable pharmaceutical intermediate. The effects of solvents, temperature, catalytic metals and amount of catalyst on the conversion and the rate of the hydrog...
  6. Oxamides as novel NR2B selective NMDA receptor antagonists

    Bioorganic & Medicinal Chemistry Letters 14(15):3953 (2004)

    Compounds of general formula A with potent p.o. analgesic activity were prepared. W=O or S; X=O, S, NH, CH 2, CH 2O or OCH 2; Y=CH 2 or O; Z=H, F, Cl or CH 3.
  7. A facile synthesis of 3-(substituted benzyl)piperidines

    Tetrahedron 59(40):7897 (2003)

    A convenient new method has been developed for preparation a series of 3-(substituted benzyl)piperidines by addition of substituted phenylmagnesium bromide to pyridine-3-carboxaldehyde followed by one pot deoxygenation and heteroaromatic ring saturation in the presence of palladium catalyst...