1. The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1-5 Chronic Kidney Disease.

    International Journal of Endocrinology 2014:142468 (2014) PMID 25250050 PMCID PMC4163314

    Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and ...
  2. Use of nicotinamide to treat hyperphosphatemia in dialysis patients.

    Drugs in R&D 13(3):165 (2013) PMID 24000048 PMCID PMC3784056

    Hyperphosphatemia in chronic kidney disease (CKD) has been associated with elevated cardiovascular morbidity and mortality. Serum phosphate control remains a cornerstone of the clinical management of patients with CKD, in order to both attenuate the progression of secondary hyperparathyroidism o...
  3. Association between angiotensin receptor blockers and better cognitive outcome: urgent need for a randomized trial.

    JAMA Neurology 70(3):413 (2013) PMID 23478839

  4. Serious spontaneous epistaxis and hypertension in hospitalized patients.

    Archiv für Ohren- Nasen- und Kehlkopfheilkunde 268(12):1749 (2011) PMID 21656167

    The aim of the study was to evaluate the role of hypertension in patients hospitalized for serious spontaneous epistaxis. This 6-year retrospective study was based on 219 patients hospitalized in a University Hospital ENT and Head and Neck surgery department for serious spontaneous epistaxis. Th...
  5. Rationale and trial design to validate an optimal dual antihypertensive treatment for prevention of dementia in very elderly patients

    Alzheimer's & Dementia 6(4):S178 (2010)

  6. Are angiotensin AT1 receptor blockers better at preventing dementia than angiotensin converting enzyme inhibitors? An update

    Alzheimer's & Dementia 6(4):S178 (2010)

  7. Pathophysiological mechanisms potentially implied in the better prevention of dementia with angiotensin AT1 receptor blockers than with angiotensin converting enzyme inhibitors

    Alzheimer's & Dementia 6(4):S222 (2010)

  8. Angiotensin AT1-receptor blockers and cerebrovascular protection: do they actually have a cutting edge over angiotensin-converting enzyme inhibitors?

    Expert Review of Neurotherapeutics 9(9):1289 (2009) PMID 19769445

    First, an update of the vascular systemic and tissue renin-angiotensin-aldosterone system is provided to explain how it is regulated at the systemic and tissue levels, and how many angiotensin peptides and receptors can be modulated by the various antihypertensive drugs. Second, experimental dat...
  9. Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.

    Expert Review of Neurotherapeutics 9(9):1413 (2009) PMID 19769454

    Our review of cohort studies and clinical trials evaluating antihypertensive drugs in the prevention of cognition decline and all dementia in patients with hypertension indicates that two antihypertensive drug classes have greater protective effects, independent of blood pressure decrease: dihyd...
  10. Vitamin D affects survival independently of vascular calcification in chronic kidney disease.

    Clinical Journal of the American Society of Nep... 4(6):1128 (2009) PMID 19443628 PMCID PMC2689889

    Cardiovascular disease is the main cause of mortality in chronic kidney disease (CKD) patients. Vitamin D might have beneficial effects on vascular health. The aim of this study was to determine the prevalence of vitamin D deficiency (25-hydroxyvitamin D [25D]
  11. About the association between high alkaline phosphatase and risk of death and hospitalization in dialysis patients.

    Kidney International 75(10):1114; author reply 1114 (2009) PMID 19404286

  12. Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors.

    Journal of Hypertension 26(10):2008 (2008) PMID 18806625

    The contribution of the AT2 and AT4 angiotensin receptors to the protective role of the AT1 receptor blocker candesartan in acute ischemic stroke was investigated. Embolic stroke was induced by injection of calibrated microspheres (50 microm) in the right internal carotid in Sprague-Dawley rats....
  13. Vitamin D levels and early mortality among incident hemodialysis patients.

    Kidney International 74(3):389; author reply 389 (2008) PMID 18626498

  14. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease.

    Kidney International 74(3):389 (2008) PMID 18626497

  15. Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis.

    Nephrology Dialysis Transplantation 23(4):1456 (2008) PMID 18039645

  16. Antihypertensive treatment and stroke prevention in patients with and without chronic kidney disease: a review of controlled trials.

    JN 21(3):374 (2008) PMID 18587726

    Stroke is the leading cause of serious long-term disability and the third leading cause of death in the Western world. In patients with chronic kidney disease (CKD), stroke and vascular dementia are significantly more prevalent than in the general population. However, the optimal stroke preventi...
  17. The JIKEI trial.

    The Lancet 370(9602):1825 (2007) PMID 18061051

  18. [Diuretic-based therapy].

    Néphrologie & Thérapeutique 3(6):392 (2007) PMID 17919642

    Diuretics are pharmacological agents that increase natriuresis through inhibition of tubular re-absorption of sodium. The mechanisms and site of this inhibition differ with each drug class, accounting for their additive effects on natriuresis increase and their hydroelectrolytic side effects. Th...
  19. Does a change in angiotensin II formation caused by antihypertensive drugs affect the risk of stroke? A meta-analysis of trials according to treatment with potentially different effects on angiotensin II.

    Journal of Hypertension 25(8):1543 (2007) PMID 17620946

    Stroke prevention by antihypertensive therapy is believed to be related to the fall in blood pressure (BP). Experimental data have documented that activation of non-AT1 receptors of angiotensin II may exert anti-ischaemic mechanisms in the brain. The present meta-analysis of various randomized c...
  20. Insulin maintains plasma antioxidant capacity at an early phase of kidney transplantation.

    Nephrology Dialysis Transplantation 22(7):1979 (2007) PMID 17449497

    Ischaemia-reperfusion and hyperglycaemia are two main sources of oxidative stress that plays an important role in the pathophysiology of tissue injury in transplant recipients. We hypothesized that controlling hyperglycaemia with insulin during the first hours following kidney transplantation co...