1. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

    Cell 162(5):1169 (2015)

  2. Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.

    Current Biology 25(14):1810 (2015) PMID 26144971

    Frataxin is a nuclear-encoded mitochondrial protein involved in the biogenesis of Fe-S-cluster-containing proteins and consequently in the functionality of the mitochondrial respiratory chain. Similar to other proteins that regulate mitochondrial respiration, severe frataxin deficiency leads to ...
  3. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Cell 162(1):146 (2015) PMID 26140595

    KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell...
  4. DNA repair mechanisms in cancer development and therapy.

    Frontiers in Genetics 6:157 (2015) PMID 25954303 PMCID PMC4407582

    DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes and tumor suppressor genes, cells undergo malignant transformation resulting in cancerous growth. Genetic defects can predispos...
  5. Corrigendum to “Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans” [Exp. Gerontol. 48 (2013) 191–201]

    Experimental Gerontology 48(9):1001 (2013)

  6. Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1.

    Nucleic Acids Research 41(10):5368 (2013) PMID 23580547 PMCID PMC3664812

    Transcription-blocking oxidative DNA damage is believed to contribute to aging and to underlie activation of oxidative stress responses and down-regulation of insulin-like signaling (ILS) in Nucleotide Excision Repair (NER) deficient mice. Here, we present the first quantitative proteomic descri...
  7. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.

    Experimental Gerontology 48(2):191 (2013) PMID 23247094 PMCID PMC3572394

    Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox indicates that cellular adaptation to partial mit...
  8. A role for p53 in mitochondrial stress response control of longevity in C. elegans.

    Experimental Gerontology 45(7-8):550 (2010) PMID 20172019

    As in the case of aging, many degenerative disorders also result from progressive mitochondrial deterioration and cellular damage accumulation. Therefore, preventing damage accumulation may delay aging and help to prevent degenerative disorders, especially those associated with mitochondrial dys...
  9. p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.

    Aging Cell 8(4):380 (2009) PMID 19416129 PMCID PMC2730656

    Mitochondrial pathologies underlie a number of life-shortening diseases in humans. In the nematode Caenorhabditis elegans, severely reduced expression of mitochondrial proteins involved in electron transport chain-mediated energy production also leads to pathological phenotypes, including arrest...