1. INTERACTIVE MEDICAL CASE. A Stinging Sensation.

    New England Journal of Medicine 372(26):e35 (2015) PMID 26107069

    This interactive feature presents the case of a 45-year-old man who has been stung by a yellow jacket, becomes light-headed and nauseated, and is brought to the emergency department. Test your diagnostic and therapeutic skills at NEJM.org.
  2. Succinate dehydrogenase gene mutations in cardiac paragangliomas.

    The American Journal of Cardiology 115(12):1753 (2015) PMID 25896150 PMCID PMC4450109

    Pheochromocytomas and paragangliomas are chromaffin cell tumors arising from neuroendocrine cells. At least 1/3 of paragangliomas are related to germline mutations in 1 of 17 genes. Although these tumors can occur throughout the body, cardiac paragangliomas are very rare, accounting for <0.3% of...
  3. Hypertension, Antihypertensive Medications, and Risk of Incident Primary Hyperparathyroidism.

    Journal of Clinical Endocrinology & Metabolism 100(6):2396 (2015) PMID 25885946 PMCID PMC4454810

    Hypertension is associated with higher PTH levels, and specific antihypertensive medications may modulate PTH. Whether hypertension or the use of specific antihypertensive medications influences the risk of developing incident primary hyperparathyroidism (P-HPTH) is not known. The purpose of thi...
  4. Cortisol dysregulation in obesity-related metabolic disorders.

    Current Opinion in Endocrinology Diabetes and O... 22(3):143 (2015) PMID 25871955 PMCID PMC4517681

    The present review highlights recent investigations in the prior 18 months focusing on the role of dysregulated cortisol physiology in obesity as a potential modifiable mechanism in the pathogenesis of obesity-related cardiometabolic disorders. Given the clinical resemblance of obesity-related m...
  5. Role of complement and complement regulatory proteins in the complications of diabetes.

    Endocrine Reviews 36(3):272 (2015) PMID 25859860 PMCID PMC4446516

    It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood. The prevalent hypothesis explaining the mecha...
  6. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25839865

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  7. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  8. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25839865

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  9. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  10. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  11. Pheochromocytoma and paraganglioma in cyanotic congenital heart disease.

    Journal of Clinical Endocrinology & Metabolism 100(4):1325 (2015) PMID 25581599 PMCID PMC4399286

    Aberrant cellular oxygen sensing is a leading theory for development of pheochromocytoma (PHEO) and paraganglioma (PGL). The objective of the study was to test the hypothesis that chronic hypoxia in patients with cyanotic congenital heart disease (CCHD) increases the risk for PHEO-PGL. We invest...
  12. Resting heart rate and the risk of developing impaired fasting glucose and diabetes: the Kailuan prospective study.

    International Journal of Epidemiology 44(2):689 (2015) PMID 26002923

    To investigate the association between resting heart rate and the risk of developing impaired fasting glucose (IFG), diabetes and conversion from IFG to diabetes. The prospective analysis included 73 357 participants of the Kailuan cohort (57 719 men and 15 638 women). Resting heart rate was mea...
  13. Interactive medical case. Itching for a diagnosis.

    New England Journal of Medicine 372(7):e10 (2015) PMID 25671274

  14. Interactive medical case. Itching for a diagnosis.

    New England Journal of Medicine 372(7):e10 (2015) PMID 25671274

  15. Interactive medical case. Itching for a diagnosis.

    New England Journal of Medicine 372(7):e10 (2015) PMID 25671274

    This interactive feature presents the case of a 58-year-old woman with pruritus, fatigue, dizziness, and decreased appetite. Test your diagnostic and therapeutic skills at NEJM.org. A 58-year-old black woman presented to an urgent care clinic with pruritus, which had develope...
  16. Aldosterone, parathyroid hormone, and the use of Renin-Angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis.

    Journal of Clinical Endocrinology & Metabolism 100(2):490 (2015) PMID 25412416 PMCID PMC4318894

    Aldosterone and PTH are implicated in the pathogenesis of cardiovascular and skeletal diseases. An expanding body of evidence supports a bidirectional and positive physiologic relationship between aldosterone and PTH. Large population-based studies confirming this relationship, and whether it ma...
  17. Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis.

    Journal of Clinical Endocrinology & Metabolism 100(2):490 (2015) PMID 25412416 PMCID PMC4318894

    Aldosterone and PTH are implicated in the pathogenesis of cardiovascular and skeletal diseases. An expanding body of evidence supports a bidirectional and positive physiologic relationship between aldosterone and PTH. Large population-based studies confirming this relationship, and whether it ma...
  18. Aldosterone, parathyroid hormone, and the use of Renin-Angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis.

    Journal of Clinical Endocrinology & Metabolism 100(2):490 (2015) PMID 25412416

    Aldosterone and PTH are implicated in the pathogenesis of cardiovascular and skeletal diseases. An expanding body of evidence supports a bidirectional and positive physiologic relationship between aldosterone and PTH. Large population-based studies confirming this relationship, and whether it ma...
  19. Interactive medical case. A Liberian health care worker with fever.

    New England Journal of Medicine 372(5):e7 (2015) PMID 25629759

    This interactive feature presents a 52-year-old woman with fever and muscle and joint pain. She also reported the development of headache, anorexia, nausea, mild diarrhea, and mild chest pains in the preceding 1 to 2 days. Test your diagnostic and therapeutic skills at NEJM.org. ...
  20. Interactive medical case. A Liberian health care worker with fever.

    New England Journal of Medicine 372(5):e7 (2015) PMID 25629759

    This interactive feature presents a 52-year-old woman with fever and muscle and joint pain. She also reported the development of headache, anorexia, nausea, mild diarrhea, and mild chest pains in the preceding 1 to 2 days. Test your diagnostic and therapeutic skills at NEJM.org. ...