1. Early Interrogation and Recognition of DNA Sequence by Indirect Readout

    Structure 16(12):1828 (2008)

    Control of replication, transcription, recombination and repair requires proteins capable of finding particular DNA sequences in a background of a large excess of nonspecific sequences. Such recognition can involve direct readout, with direct contacts to the bases of DNA, or in some ca...
  2. Early interrogation and recognition of DNA sequence by indirect readout.

    Structure 16(12):1828 (2008) PMID 19081059 PMCID PMC2637360

    Control of replication, transcription, recombination and repair requires proteins capable of finding particular DNA sequences in a background of a large excess of nonspecific sequences. Such recognition can involve direct readout, with direct contacts to the bases of DNA, or in some cases throug...
  3. DNA distortion and specificity in a sequence-specific endonuclease.

    Journal of Molecular Biology 383(1):186 (2008) PMID 18762194 PMCID PMC2605692

    Five new structures of the Q138F HincII enzyme bound to a total of three different DNA sequences and three different metal ions (Ca(2+), Mg(2+), and Mn(2+)) are presented. While previous structures were produced from soaking Ca(2+) into preformed Q138F HincII/DNA crystals, the new structures are...
  4. DNA Distortion and Specificity in a Sequence-Specific Endonuclease

    Journal of Molecular Biology 383(1):186 (2008)

    Five new structures of the Q138F HincII enzyme bound to a total of three different DNA sequences and three different metal ions (Ca 2+, Mg 2+, and Mn 2+) are presented. While previous structures were produced from soaking Ca 2+ into preformed Q138F HincII/DNA crystal...
  5. Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.

    PNAS 104(45):17741 (2007) PMID 17962420 PMCID PMC2077068

    Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work,...
  6. Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.

    PNAS 104(45):17741 (2007) PMID 17962420 PMCID PMC2077068

    Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work,...
  7. Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda.

    Molecular Microbiology 64(1):232 (2007) PMID 17376085

    The gene regulatory circuitry of phage lambda is among the best-understood circuits. Much of the circuitry centres around the immunity region, which includes genes for two repressors, CI and Cro, and their cis-acting sites. Related phages, termed lambdoid phages, have different immunity regions,...
  8. Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda.

    Molecular Microbiology 64(1):232 (2007) PMID 17376085

    The gene regulatory circuitry of phage lambda is among the best-understood circuits. Much of the circuitry centres around the immunity region, which includes genes for two repressors, CI and Cro, and their cis-acting sites. Related phages, termed lambdoid phages, have different immunity regions,...