1. A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.

    Journal of Leukocyte Biology 97(4):635 (2015) PMID 25548254

    CD8 coreceptor expression is dynamically regulated during thymocyte development and is tightly controlled by the activity of at least 5 different cis-regulatory elements. Despite the detailed characterization of the Cd8 loci, the regulation of the complex expression pattern of CD8 cannot be full...
  2. Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.

    Journal of Immunology 194(4):1755 (2015) PMID 25567678

    Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in...
  3. Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.

    Journal of Immunology 194(4):1755 (2015) PMID 25567678 PMCID PMC4323683

    Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in...
  4. Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.

    Journal of Immunology 194(4):1755 (2015) PMID 25567678

    Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in...
  5. Protective efficacy of individual CD8+ T cell specificities in chronic viral infection.

    Journal of Immunology 194(4):1755 (2015) PMID 25567678 PMCID PMC4323683

    Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in...
  6. Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.

    Journal of Immunology 194(4):1755 (2015) PMID 25567678

    Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in...
  7. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

    European Journal of Immunology 45(2):418 (2015) PMID 25393615 PMCID PMC4383653

    STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral for the function of multiple immune cell types. Human mutations in STAT3 cause primary immunodeficiency resulting in impaired control of a variety of infections, including reactivation of latent v...
  8. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

    European Journal of Immunology 45(2):418 (2015) PMID 25393615

    STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral for the function of multiple immune cell types. Human mutations in STAT3 cause primary immunodeficiency resulting in impaired control of a variety of infections, including reactivation of latent v...
  9. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.

    Nature Immunology 16(1):67 (2015) PMID 25419628 PMCID PMC4320687

    Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus. Setdb2 expression depended on signaling via type I interferons, and ...
  10. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.

    Nature Immunology 16(1):67 (2015) PMID 25419628 PMCID PMC4320687

    Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus. Setdb2 expression depended on signaling via type I interferons, and ...
  11. Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness.

    Journal of Virology 88(15):8340 (2014) PMID 24829355 PMCID PMC4135970

    A key characteristic of arenaviruses is their ability to establish persistent infection in their natural host. Different factors like host age, viral dose strain, and route of infection may contribute to the establishment of persistence. However, the molecular mechanisms governing persistence ar...
  12. Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness.

    Journal of Virology 88(15):8340 (2014) PMID 24829355 PMCID PMC4135970

    A key characteristic of arenaviruses is their ability to establish persistent infection in their natural host. Different factors like host age, viral dose strain, and route of infection may contribute to the establishment of persistence. However, the molecular mechanisms governing persistence ar...
  13. Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness.

    Journal of Virology 88(15):8340 (2014) PMID 24829355 PMCID PMC4135970

    A key characteristic of arenaviruses is their ability to establish persistent infection in their natural host. Different factors like host age, viral dose strain, and route of infection may contribute to the establishment of persistence. However, the molecular mechanisms governing persistence ar...
  14. Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness.

    Journal of Virology 88(15):8340 (2014) PMID 24829355 PMCID PMC4135970

    A key characteristic of arenaviruses is their ability to establish persistent infection in their natural host. Different factors like host age, viral dose strain, and route of infection may contribute to the establishment of persistence. However, the molecular mechanisms governing persistence ar...
  15. Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

    Journal of Experimental Medicine 210(10):2087 (2013) PMID 23999498 PMCID PMC3782053

    Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons...
  16. Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

    Journal of Experimental Medicine 210(10):2087 (2013) PMID 23999498 PMCID PMC3782053

    Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons...
  17. Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.

    PLoS ONE 8(12):e85302 (2013) PMID 24376875 PMCID PMC3871569

    Infant mortality from viral infection remains a major global health concern: viruses causing acute infections in immunologically mature hosts often follow a more severe course in early life, with prolonged or persistent viral replication. Similarly, the WE strain of lymphocytic choriomeningitis ...
  18. Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.

    PLoS ONE 8(12):e85302 (2013) PMID 24376875 PMCID PMC3871569

    Infant mortality from viral infection remains a major global health concern: viruses causing acute infections in immunologically mature hosts often follow a more severe course in early life, with prolonged or persistent viral replication. Similarly, the WE strain of lymphocytic choriomeningitis ...
  19. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.

    Nature 490(7420):421 (2012) PMID 22982991 PMCID PMC3556990

    Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses and their transcription is regulated by a variety of transcription factors; principal among these is the...
  20. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.

    Nature 490(7420):421 (2012) PMID 22982991 PMCID PMC3556990

    Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses and their transcription is regulated by a variety of transcription factors; principal among these is the...