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  1. Structural Study of the Reaction of Methylzinc Amino Alcoholates with Oxygen

    Organometallics 29(15):3318 (2010)

  2. The use of modelling to predict levels of estrogens in a river catchment: How does modelled data compare with chemical analysis and in vitro...

    Science of The Total Environment 408(20):7 (2010) PMID 20673965

    Effluent discharges at Rodbourne sewage treatment works (STWs) were assessed using chemical and in vitro biological analysis as well as modelling predictions. Results showed that Rodbourne STW discharged less estrone (E1) than expected, but similar 17beta-estradiol (E2) and 17alpha-e...
  3. Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Re...

    Circulation: Cardiovascular Genetics 7(3):374 (2014) PMID 24951664 PMCID PMC4066205

    We sequenced 5 gene regions at 11p11.2 to identify rare, potentially functional variants influencing fasting glucose or FI levels. Sequencing (mean depth, 38×) across 16.1 kb in 3566 individuals without diabetes mellitus identified 653 variants, 79.9% of which were rare (minor allele frequency <1%)...
  4. Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos.

    Development 141(12):2429 (2014) PMID 24917499 PMCID PMC4050694

    We studied PGC specification in embryos from the axolotl (Mexican salamander), a model for the tetrapod ancestor. In the axolotl, PGCs develop within mesoderm, and classic studies have reported their induction from primitive ectoderm (animal cap). We used an axolotl animal cap system to demonstrate...
  5. Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.

    PLoS ONE 9(1):e85848 (2014) PMID 24454937 PMCID PMC3893275

    We therefore addressed the role of PKCδ in the development of steatosis, inflammation, oxidative stress, apoptosis, and fibrosis in an animal model of NASH. We fed PKCδ(-/-) mice and wildtype littermates a control or MCD diet. PKCδ(-/-) primary hepatocytes were used to evaluate the direct effects of...
  6. The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.

    PLoS ONE 7(6):e37237 (2012) PMID 22701564 PMCID PMC3372482

    We recruited fifteen trained men (VO(2)peak = 4.7±0.8 L min(-1)/58±8 mL kg(-1) min(-1)) and performed duplicate MR experiments during plantar flexion exercise, three weeks apart. Measures of resting phosphorus metabolites were reproducible, with 1.7 mM the smallest detectable difference in phosphocr...
  7. Levels of connectivity between longnose skate (Dipturus oxyrinchus) in the Mediterranean Sea and the north-eastern Atlantic Ocean

    Conservation Genetics 12(2):577 (2011)

  8. A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes.

    Organic & Biomolecular Chemistry 7(17):3537 (2009) PMID 19675911

    A novel way of combining chiral auxiliaries and substrate directable reactions is described that employs a three-step sequence of aldol/cyclopropanation/retro-aldol reactions for the asymmetric synthesis of enantiopure cyclopropane-carboxaldehydes. In the first step, reaction of the boron enolate of...
  9. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap.

    Journal of Gerontology 24(24):2938 (2008) PMID 18974171 PMCID PMC2720775

    We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpr...
  10. Autumn Stopover Near The Gulf Of Honduras By Nearctic-Neotropic Migrants

    Wilson Journal of Ornithology 120(2):277 (2008)