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  1. Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and...

    Arteriosclerosis, Thrombosis, and Vascular Biology 34(5):1093 (2014) PMID 24578379

    We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA. Fourteen cohort studies with tPA measures (N=26 929) contributed to the meta-analysis. Three loci were significantly associated with circulating tPA levels (P<5.0×10(-8)). The f...
  2. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obes...

    PLoS Genetics 8(5):e1002741 (2012) PMID 22693455 PMCID PMC3364960

    We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m²) compared to obese cases (BMI≥30 Kg/m²). We performed two case-control genome-wide studies using two accepted cut-offs for defining individuals as overweight or obese. We used 2,112 lean type 2 diab...
  3. Membrane permeation of testosterone from either solutions, particle dispersions, or particle-stabilized emulsions.

    Langmuir 28(5):2510 (2012) PMID 22224415

    We derive a unified model that accounts for the variation in extent and rate of membrane permeation by a permeating species with the type of donor compartment formulation (aqueous and oil solutions, particle dispersions, and oil-in-water and water-in-oil emulsions stabilized by particles) initially...
  4. Chewing gum modifies state anxiety and alertness under conditions of social stress.

    Nutritional Neuroscience 14(6):237 (2011) PMID 22053754

    Objectives The finding that chewing gum can moderate state anxiety under conditions of acute stress has proved difficult to replicate. The present study examines the extent to which chewing gum can moderate state anxiety under conditions of acute social stress. Method In a between-...
  5. Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.

    Hypertension 57(5):903 (2011) PMID 21444836 PMCID PMC3099407

    We previously conducted genome-wide association meta-analysis of systolic blood pressure, diastolic blood pressure, and hypertension in 29,136 people from 6 cohort studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Here we examine associations of these traits wit...
  6. An assessment of the fate, behaviour and environmental risk associated with sunscreen TiO₂ nanoparticles in UK field scenarios.

    Science of The Total Environment 409(13):2503 (2011) PMID 21501856

    The fate of Ti was examined in an activated sludge plant serving over 200,000 people. These studies revealed a decrease of 30 to 3.2μg/L of Ti<0.45μm from influent to effluent and a calculated Ti presence of 305mg/kg DW in wasted sludge. Thus, using sludge as a fertiliser would res...
  7. Epigenetic reprogramming of breast cancer cells with oocyte extracts.

    Molecular Cancer 10(1):7 (2011) PMID 21232089 PMCID PMC3034708

    We apply the reprogramming capacity of oocytes to cancer cells in order to study breast oncogenesis. We show that breast cancer cells can be directly reprogrammed by amphibian oocyte extracts. The reprogramming effect, after six hours of treatment, in the absence of DNA replication, includes DNA dem...
  8. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts fo...

    Circulation 121(12):1382 (2010) PMID 20231535 PMCID PMC2861278

    We conducted genome-wide association studies to identify new loci associated with plasma levels. The setting of the study included 5 community-based studies for discovery comprising 23 608 European-ancestry participants: Atherosclerosis Risk In Communities Study, Cardiovascular Health Study, British...
  9. Rural hospitals and Spanish-speaking patients with limited English proficiency.

    Journal of Healthcare Management 53(2):107 (2008) PMID 18421995

    Between 1990 and 2000, the Latino population in the United States increased by 61 percent, becoming the largest minority group. Language differences contribute to patient safety and access to healthcare concerns for limited English proficiency (LEP) Latinos. The objectives of this research were to d...
  10. Response To Comment on “Lessons from Endocrine Disruption and Their Application to Other Issues Concerning Trace Organics in the Aquatic Env...

    Environmental Science & Technology 40(3):1086 (2006)