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  1. BactoGeNIE: a large-scale comparative genome visualization for big displays.

    BMC Bioinformatics 16 Suppl 11:S6 (2015) PMID 26329021 PMCID PMC4547189

    The volume of complete bacterial genome sequence data available to comparative genomics researchers is rapidly increasing. However, visualizations in comparative genomics--which aim to enable analysis tasks across collections of genomes--suffer from visual scalability issues. While large, multi-...
  2. Antimicrobial Susceptibility of Escherichia coli in Uncomplicated Cystitis in the Emergency Department: Is the Hospital Antibiogram an Effective Treatment Guide?

    Academic Emergency Medicine 22(8):998 (2015) PMID 26250654

    The objective was to compare the rates of antimicrobial susceptibility in strains of Escherichia coli isolated from uncomplicated cystitis cases presenting to the emergency department (ED) of a tertiary care center to those reported on that institution's hospital-wide antibiogram. The hypothesis...
  3. Genome-wide association study of kidney function decline in individuals of European descent.
    Mathias Gorski, Adrienne Tin, Maija Garnaas, Gearoid M, Audrey Y Chu, Bamidele O Tayo, Cristian Pattaro, Alexander Teumer, Daniel I Chasman, John Chalmers, Pavel Hamet, Johanne Tremblay, Marc Woodward, Thor Aspelund, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Braxton D Mitchell, Jeffrey R O'Connell, Alan R Shuldiner, Josef Coresh, Man Li, Paul Freudenberger, Edith Hofer, Helena Schmidt, Reinhold Schmidt, Elizabeth G Holliday, Paul Mitchell, Jie Jin Wang, Ian H de Boer, Guo Li, David Siscovick, Zoltan Kutalik, Tanguy Corre, Peter Vollenweider, Gérard Waeber, Jayanta Gupta, Peter A Kanetsky, Shih-Jen Hwang, Matthias Olden, Qiong Yang, Mariza de Andrade, Elizabeth J Atkinson, Sharon L R Kardia, Stephen Turner, Jeanette M Stafford, Jingzhong Ding, Yongmei Liu, Cristina Barlassina, Daniele Cusi, Erika Salvi, Jan A Staessen, Paul M Ridker, Harald Grallert, Christa Meisinger, Martina Müller-Nurasyid, Bernhard Krämer, Holly Kramer, Sylvia E Rosas, Ilja M Nolte, Brenda W Penninx, Harold Snieder, M Fabiola Del Greco, Andre Franke, Ute Nöthlings, Wolfgang Lieb, Stephan J L Bakker, Ron T Gansevoort, Pim van der Harst, Abbas Dehghan, Oscar H Franco, Albert Hofman, Fernando Rivadeneira, Sanaz Sedaghat, André G Uitterlinden, Stefan Coassin, Margot Haun, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Nicole Aumann, Karlhans Endlich, Mike Pietzner, Uwe Völker, Rainer Rettig, Vincent Chouraki, Catherine Helmer, Jean-Charles Lambert, Marie Metzger, Benedicte Stengel, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli Raitakari, Andrew Johnson, Afshin Parsa, Murielle Bochud, Iris M Heid, Wolfram Goessling, Anna Köttgen, W H Linda Kao, Caroline S Fox, and Carsten A Böger

    Kidney International 87(5):1017 (2015) PMID 25493955 PMCID PMC4425568

    Genome-wide association studies (GWASs) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS meta-analysis among 63,558 participants of European descent, initially from 16 c...
  4. CO₂ and inorganic nutrient enrichment affect the performance of a calcifying green alga and its noncalcifying epiphyte.

    Oecologia 177(4):1157 (2015) PMID 25648647

    Ocean acidification studies in the past decade have greatly improved our knowledge of how calcifying organisms respond to increased surface ocean CO2 levels. It has become evident that, for many organisms, nutrient availability is an important factor that influences their physiological responses...
  5. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes.

    Nature Medicine 21(3):239 (2015) PMID 25706874 PMCID PMC4429798

    Insulin resistance results from several pathophysiologic mechanisms, including chronic tissue inflammation and defective insulin signaling. We found that liver, muscle and adipose tissue exhibit higher levels of the chemotactic eicosanoid LTB4 in obese high-fat diet (HFD)-fed mice. Inhibition of...
  6. One size does not fit all. Management of the laparoscopic adjustable gastric band in pregnancy: a national prospective cohort study.

    The Lancet 385 Suppl 1:S32 (2015) PMID 26312854

    Pregnancies are increasingly seen in women with a gastric band, but no guidance exists on band management during pregnancy. Although band inflation can prevent excessive gestational weight gain and its associated complications, it might have detrimental effects on fetal growth. We compared mater...
  7. Development and validation of a virtual human vignette to compare nurses' assessment and intervention choices for pain in critically ill children.

    Simulation in Healthcare The Journal of the Soc... 10(1):14 (2015) PMID 25514587 PMCID PMC4315722

    As virtual experiences are increasingly used in health care training and research, it is important that adequate processes are applied for developing valid scenarios. We describe the development and validation of virtual human (VH) vignettes, computer-generated scenarios with animated patients a...
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  9. PICU Nurses' Pain Assessments and Intervention Choices for Virtual Human and Written Vignettes.

    Journal of Pediatric Nursing 30(4):580 (2015) PMID 25682019 PMCID PMC4470724

    The purpose of this concurrent mixed-methods study was to 1) examine the factors pediatric intensive care unit nurses consider when assessing and intervening for children who report severe pain and to 2) determine the effect of child behavior and diagnosis on the nurses' pain ratings and interve...
  10. Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report.

    The Canadian journal of infectious diseases = J... 26(1):41 (2015) PMID 25798154 PMCID PMC4353269

    Cardiobacterium hominis, a member of the HACEK group of organisms, is an uncommon but important cause of subacute bacterial endocarditis. First-line therapy is a third-generation cephalosporin due to rare beta-lactamase production. The authors report a case involving endovascular infection due t...