1. daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.

    Diabetologia 58(2):393 (2015) PMID 25322843

    The aim of this study was to determine the protective effects of human insulin and its analogues, B28Asp human insulin (insulin aspart) and B29Lys(ε-tetradecanoyl),desB30 human insulin (insulin detemir), against glucose-induced lifespan reduction and neuronal damage in the model organism Caenorh...
  2. daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.

    Diabetologia 58(2):393 (2015) PMID 25322843

    The aim of this study was to determine the protective effects of human insulin and its analogues, B28Asp human insulin (insulin aspart) and B29Lys(ε-tetradecanoyl),desB30 human insulin (insulin detemir), against glucose-induced lifespan reduction and neuronal damage in the model organism Caenorh...
  3. Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.

    Atherosclerosis 235(2):444 (2014) PMID 24945577

    Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA. Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic mal...
  4. Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

    Atherosclerosis 235(2):444 (2014)

    Objective/Rationale Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA.
  5. Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes.

    Acta Diabetologica 51(3):479 (2014) PMID 24366425

    Adiponectin and urinary adiponectin excretions have been ascribed a function in glomerular physiology and seem to indicate vascular disease in diabetes. The aim of this study was to compare the urinary excretion of albumin and adiponectin as predictors for decline of renal function in patients w...
  6. Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance.

    Arteriosclerosis, Thrombosis, and Vascular Biology 34(6):1199 (2014) PMID 24723555

    Dysregulation of inflammatory adipokines by the adipose tissue plays an important role in obesity-associated insulin resistance. Pathways leading to this dysregulation remain largely unknown. We hypothesized that the receptor for advanced glycation end products (RAGE) and the ligand N(ε)-(carbox...
  7. THE ROLE OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS AND ITS LIGAND HIGH MOBILITY GROUP BOX 1 IN AUTOIMMUNE MYOCARDITIS

    Journal of the American College of Cardiology 63(12):A972 (2014)

  8. RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

    PLoS ONE 9(2):e89548 (2014) PMID 24586862 PMCID PMC3935881

    RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD). RAGE null (RAGE-/-) m...
  9. Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes.

    Acta Diabetologica 51(3):479 (2014) PMID 24366425

    Adiponectin and urinary adiponectin excretions have been ascribed a function in glomerular physiology and seem to indicate vascular disease in diabetes. The aim of this study was to compare the urinary excretion of albumin and adiponectin as predictors for decline of renal function in patients w...
  10. RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

    PLoS ONE 9(2):e89548 (2014) PMID 24586862 PMCID PMC3935881

    RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD). RAGE null (RAGE-/-) m...
  11. The receptor for advanced glycation end products is dispensable in a mouse model of oral and esophageal carcinogenesis.

    Histology and histopathology 28(12):1585 (2013) PMID 23712426

    Aberrant expression of the receptor for advanced glycation end products (RAGE) and its ligands, such as S100/Calgranulins, has been demonstrated in squamous cell carcinomas of the upper aerodigestive tract. However, the question whether RAGE signaling is causally linked with neoplastic transform...
  12. Quinapril Treatment Abolishes Diabetes-Associated Atherosclerosis in RAGE/Apolipoprotein E Double Knockout Mice

    Atherosclerosis (2013)

    Objective/Rationale Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA.
  13. Quinapril Treatment Abolishes Diabetes-Associated Atherosclerosis in RAGE/Apolipoprotein E Double Knockout Mice

    Atherosclerosis (2013)

    Objective/Rationale Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA.
  14. Quinapril Treatment Abolishes Diabetes-Associated Atherosclerosis in RAGE/Apolipoprotein E Double Knockout Mice

    Atherosclerosis (2013)

    Objective/Rationale Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA.
  15. RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation.

    Kidney International 84(5):911 (2013) PMID 23677242

    Urinary tract obstruction during nephron development causes tubular apoptosis, tubular atrophy, and interstitial fibrosis. Leukocyte recruitment is critical in the development of obstructive nephropathy leading to interstitial inflammation and renal fibrosis. RAGE, the receptor of advanced glyca...
  16. Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes.

    Diabetes Care 36(7):2077 (2013) PMID 23378622 PMCID PMC3687279

    Diabetic nephropathy (DN) has mainly been considered a glomerular disease, although tubular dysfunction may also play a role. This study assessed the predictive value for progression of a tubular marker, urinary liver-type fatty acid-binding protein (L-FABP), at all stages of DN. At baseline, 1,...
  17. Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice.

    Hepatology 58(1):363 (2013) PMID 23504974

    The receptor for advanced glycation endproducts (RAGE) is a multiligand receptor and member of the immunoglobulin superfamily. RAGE is mainly involved in tissue damage and chronic inflammatory disorders, sustaining the inflammatory response upon engagement with damage-associated molecular patter...
  18. Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects.

    Diabetes and Vascular Disease Research 10(4):380 (2013) PMID 23520177

    This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and ...
  19. CD166/ALCAM mediates proinflammatory effects of S100B in delayed type hypersensitivity.

    Journal of Immunology 191(1):369 (2013) PMID 23729438 PMCID PMC3690325

    Promiscuity of pattern recognition receptors, such as receptor for advanced glycation end products (RAGE), allows for a complex regulatory network controlling inflammation. Scavenging of RAGE ligands by soluble RAGE treatment is effective in reducing delayed-type hypersensitivity (DTH), even in ...
  20. Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

    Journal of Diabetes and its Complications 27(3):262 (2013)

    Aims The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus.