1. Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.

    Nature Communications 5:4168 (2014) PMID 24942669

    β-Catenin mediates the canonical Wnt pathway by stimulating Tcf-dependent transcription and also associates to N-cadherin at the apical complex (AC) of neuroblasts. Here, we show that while β-catenin activity is required to form the AC and to maintain the cell polarity, oncogenic mutations that ...
  2. Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.

    Nature Communications 5:4168 (2014) PMID 24942669

    β-Catenin mediates the canonical Wnt pathway by stimulating Tcf-dependent transcription and also associates to N-cadherin at the apical complex (AC) of neuroblasts. Here, we show that while β-catenin activity is required to form the AC and to maintain the cell polarity, oncogenic mutations that ...
  3. Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins.

    Journal of Biological Chemistry 286(10):8067 (2011) PMID 21209076 PMCID PMC3048693

    Proliferation of cerebellar granular neuronal precursors (CGNPs) is mediated by Sonic Hedgehog (Shh), which activates the Patched and Smoothened (Smo) receptor complex. Although its protein sequence suggests that Smo is a G protein coupled receptor (GPCR), the evidence that this receptor utilize...
  4. Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins.

    Journal of Biological Chemistry 286(10):8067 (2011) PMID 21209076 PMCID PMC3048693

    Proliferation of cerebellar granular neuronal precursors (CGNPs) is mediated by Sonic Hedgehog (Shh), which activates the Patched and Smoothened (Smo) receptor complex. Although its protein sequence suggests that Smo is a G protein coupled receptor (GPCR), the evidence that this receptor utilize...
  5. Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

    Journal of Cell Science 123(Pt 1):62 (2010) PMID 20016067

    Cerebellar granular neuronal precursors (CGNPs) proliferate in response to the mitogenic activity of Sonic hedgehog (Shh), and this proliferation is negatively regulated by activation of cAMP-dependent protein kinase (PKA). In the basal state, the PKA catalytic subunits (C-PKA) are inactive beca...
  6. Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

    Journal of Cell Science 123(Pt 1):62 (2010) PMID 20016067

    Cerebellar granular neuronal precursors (CGNPs) proliferate in response to the mitogenic activity of Sonic hedgehog (Shh), and this proliferation is negatively regulated by activation of cAMP-dependent protein kinase (PKA). In the basal state, the PKA catalytic subunits (C-PKA) are inactive beca...