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  1. DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach.

    BMC Gastroenterology 14:55 (2014) PMID 24674026 PMCID PMC3986689

    Methylation-induced silencing of promoter CpG islands in tumor suppressor genes plays an important role in human carcinogenesis. In colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinctive clin...
  2. Clinical potential of DNA methylation in gastric cancer: a meta-analysis.

    PLoS ONE 7(4):e36275 (2012) PMID 22558417 PMCID PMC3338684

    Accumulating evidence indicates aberrant DNA methylation is involved in gastric tumourigenesis, suggesting it may be a useful clinical biomarker for the disease. The aim of this study was to consolidate and summarize published data on the potential of methylation in gastric cancer (GC) risk pred...
  3. Impact of sample heterogeneity on methylation analysis.

    Diagnostic Molecular Pathology 19(4):243 (2010) PMID 21051995

    The recent emergence of high-throughput arrays for methylation analysis has made the influence of tumor content on the interpretation of methylation levels increasingly pertinent. However, to what degree does tumor content have an influence, and what degree of tumor content makes a specimen acce...
  4. MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer

    European Journal of Cancer 46(8):1456 (2010) PMID 20176475

    Aim Accumulating evidence indicates that RUNX3 is an important tumour suppressor that is inactivated in many cancer types. This study aimed to assess the role of microRNA (miRNA) in the regulation of RUNX3.
  5. Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.

    BMC Cancer 10:227 (2010) PMID 20492682 PMCID PMC2880997

    Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups. DNA methy...
  6. MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer

    European Journal of Cancer 46(8):1456 (2010) PMID 20176475

    Aim Accumulating evidence indicates that RUNX3 is an important tumour suppressor that is inactivated in many cancer types. This study aimed to assess the role of microRNA (miRNA) in the regulation of RUNX3.
  7. Degradation of human secretory immunoglobulin A by Blastocystis.

    Parasitology Research 97(5):386 (2005) PMID 16151742

    Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory I...