1. Severe Malaria Not Responsive to Artemisinin Derivatives in Man Returning from Angola to Vietnam.

    Emerging Infectious Diseases 21(7):1264 (2015) PMID 26079641 PMCID PMC4480383

  2. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.

    Nature 520(7549):683 (2015) PMID 25874676 PMCID PMC4417027

    Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global level. Genome-wide association studies (GWAS) ...
  3. Treatment of Ebola.

    New England Journal of Medicine 372(17):1673 (2015) PMID 25901440

  4. Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

    PLOS Medicine 12(4):e1001823 (2015) PMID 25919029 PMCID PMC4412633

    Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' and in vitro sensitivity tests. However, curren...
  5. Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

    PLoS Biology 13(4):e1002132 (2015) PMID 25901609 PMCID PMC4406523

    Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutat...
  6. Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria.

    Journal of Infectious Diseases 211(7):1128 (2015) PMID 25344520

    In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia. We assessed whether the plasma Plasmodium falciparum DNA concentration is a useful datum for distinguishing un...
  7. Pulmonary tuberculosis induces a systemic hypercoagulable state

    Journal of Infection 70(4):324 (2015) PMID 25455017

    Objectives Human tuberculosis (TB) remains an important cause of death globally. Bangladesh is one of the most affected countries. We aimed to investigate the impact of pulmonary TB on pro- and anticoagulant mechanisms.
  8. Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria.

    Journal of Infectious Diseases 211(7):1128 (2015) PMID 25344520 PMCID PMC4354984

    In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia. We assessed whether the plasma Plasmodium falciparum DNA concentration is a useful datum for distinguishing un...
  9. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.

    The Lancet Infectious Diseases 15(4):415 (2015) PMID 25704894 PMCID PMC4374103

    Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remote areas...
  10. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.

    Journal of Infectious Diseases 211(5):670 (2015) PMID 25180241 PMCID PMC4334802

    The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. P. falciparum infection...
  11. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  12. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype.

    Infection, Genetics and Evolution 30:318 (2015) PMID 25514047 PMCID PMC4316729

    Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast As...
  13. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  14. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia.

    Journal of Infectious Diseases 211(5):670 (2015) PMID 25180241 PMCID PMC4334802

    The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. P. falciparum infection...
  15. Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Nature Genetics 47(3):226 (2015) PMID 25599401

    We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domai...
  16. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  17. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  18. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  19. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

    Science 347(6220):431 (2015) PMID 25502316

    Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptome...
  20. The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis.

    BMC Medicine 13(1):97 (2015) PMID 25907925 PMCID PMC4408603

    Thrombocytopenia is a common finding in adults with severe falciparum malaria, but its clinical and prognostic utility is incompletely defined. Clinical and laboratory data from 647 adults with severe falciparum malaria were analysed retrospectively to determine the relationship between a patien...