1. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  2. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  3. The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.

    Journal of Interferon & Cytokine Research 30(6):389 (2010) PMID 20187768

    Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15), a divergent member of the TGF-beta superfamily is induced by a range of proinflammatory cytokines and oxidized low-density lipoprotein (oxLDL) and is highly expressed in macrophages in atherosclerotic and tumor lesi...
  4. The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.

    Journal of Interferon & Cytokine Research 30(6):389 (2010) PMID 20187768

    Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15), a divergent member of the TGF-beta superfamily is induced by a range of proinflammatory cytokines and oxidized low-density lipoprotein (oxLDL) and is highly expressed in macrophages in atherosclerotic and tumor lesi...
  5. Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss.

    Prostate 69(6):652 (2009) PMID 19152406

    Macrophage inhibitory cytokine-1 (MIC-1) belongs to the bone morphogenic protein/transforming growth factor-beta (BMP/TGF-beta) superfamily. Serum MIC-1 concentrations are elevated in patients with advanced prostate cancer. The effects of MIC-1 on prostate cancer bone metastases are unknown. In ...
  6. Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss.

    Prostate 69(6):652 (2009) PMID 19152406

    Macrophage inhibitory cytokine-1 (MIC-1) belongs to the bone morphogenic protein/transforming growth factor-beta (BMP/TGF-beta) superfamily. Serum MIC-1 concentrations are elevated in patients with advanced prostate cancer. The effects of MIC-1 on prostate cancer bone metastases are unknown. In ...
  7. 337 The TGF-β superfamily cytokine MIC-1 causes tumour-induced anorexia/cachexia by modulating appetite control centres in the hypothalamus

    Cytokine 43(3):323 (2008)

  8. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  9. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  10. Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction.

    Arthritis & Rheumatism 56(3):753 (2007) PMID 17328047

    The transforming growth factor beta superfamily member macrophage inhibitory cytokine 1 (MIC-1) is expressed upon macrophage activation, regulated by the p53 pathway, and linked to clinical events in atherosclerosis and cancer. Since rheumatoid arthritis (RA) shares similar etiopathologic mechan...
  11. Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction.

    Arthritis & Rheumatism 56(3):753 (2007) PMID 17328047

    The transforming growth factor beta superfamily member macrophage inhibitory cytokine 1 (MIC-1) is expressed upon macrophage activation, regulated by the p53 pathway, and linked to clinical events in atherosclerosis and cancer. Since rheumatoid arthritis (RA) shares similar etiopathologic mechan...
  12. Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.

    Cancer Research 66(10):4983 (2006) PMID 16707416

    Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cel...
  13. Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.

    Cancer Research 66(10):4983 (2006) PMID 16707416

    Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cel...
  14. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

    Circulation Research 98(3):342 (2006) PMID 16397142

    Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth factor (TGF)-beta superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF15 is not expressed in the normal adult heart but is induced in response t...
  15. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

    Circulation Research 98(3):342 (2006) PMID 16397142

    Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth factor (TGF)-beta superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF15 is not expressed in the normal adult heart but is induced in response t...
  16. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis.

    Clinical Cancer Research 12(1):89 (2006) PMID 16397029

    Current serum testing for the detection of prostate cancer (PCa) lacks specificity. On diagnosis, the optimal therapeutic pathway is not clear and tools for adequate risk assessment of localized PCa progression are not available. This leads to a significant number of men having unnecessary diagn...
  17. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis.

    Clinical Cancer Research 12(1):89 (2006) PMID 16397029

    Current serum testing for the detection of prostate cancer (PCa) lacks specificity. On diagnosis, the optimal therapeutic pathway is not clear and tools for adequate risk assessment of localized PCa progression are not available. This leads to a significant number of men having unnecessary diagn...
  18. The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome.

    Cancer Research 65(6):2330 (2005) PMID 15781647

    The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such as prostate cancer. Carcinomas commonly overexpress macrophage inhibitory cytokine 1 (MIC-1)...
  19. The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome.

    Cancer Research 65(6):2330 (2005) PMID 15781647

    The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such as prostate cancer. Carcinomas commonly overexpress macrophage inhibitory cytokine 1 (MIC-1)...
  20. The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.

    Journal of Biological Chemistry 279(10):9298 (2004) PMID 14613939

    Most proteins adopt a well defined three-dimensional structure; however, it is increasingly recognized that some proteins can exist with at least two stable conformations. Recently, a class of intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integra...
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