Interobserver Agreement Between Pathologists Assessing Tumor-Infiltrating Lymphocytes (TILs) in Breast Cancer Using Methodology Proposed by the International TILs Working Group.
Annals of Surgical Oncology 23(7):2242 (2016)
The presence of tumor-infiltrating lymphocytes (TILs) in breast tumors is prognostic and predictive, suggesting that TILs may be an important biomarker. Recently, an international TILs working group formulated consensus recommendations for TIL evaluation. The current study was performed to deter...
EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape.
Cancer Research 76(5):1284 (2016)
Oncogenic signaling reprograms cancer cell metabolism to augment the production of glycolytic metabolites in favor of tumor growth. The ability of cancer cells to evade immunosurveillance and the role of metabolic regulators in T-cell functions suggest that oncogene-induced metabolic reprogrammi...
Phyllodes tumours of the breast: a consensus review.
Histopathology 68(1):5 (2016)
Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pa...
Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.
PLoS ONE 11(3):e0151121 (2016)
Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.
American Journal of Clinical Pathology 144(5):713 (2015)
The advent of next-generation sequencing (NGS) platforms in the realm of clinical molecular diagnostics provides multigene mutational profiling through massively parallel sequencing.
We analyzed 415 breast carcinoma samples from 354 patients using NGS in known hotspots of 46 commonly known cance...
Metastatic Tumor Volume and Extranodal Tumor Extension: Clinical Significance in Patients With Stage II Breast Cancer.
Archives of Pathology & Laboratory Medicine 139(10):1288 (2015)
Lymph node status and the number of lymph node (LN) positive for cancer cells are the most important prognostic factors in breast cancer. Extranodal tumor extension (ENTE) has been used as a histopathologic feature to classify patients into high risk versus low risk for local recurrence. However...
A new affinity gel for the purification of α-carbonic anhdrases.
Journal of Enzyme Inhibition and Medicinal Chem... 30(2):224 (2015)
The new affinity gel reported in this study was prepared using EUPERGIT C250L as a chromatographic bed material, to which etylenediamine spacer arms were attached to prevent steric hindrance between the matrix and ligand, and to facilitate effective binding of the CA-specific ligand, of the arom...
Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes.
PLoS ONE 10(9):e0136851 (2015)
Breast cancer patients who are resistant to neoadjuvant chemotherapy (NeoCT) have a poor prognosis. There is a pressing need to develop in vivo models of chemo resistant tumors to test novel therapeutics. We hypothesized that patient-derived breast cancer xenografts (BCXs) from chemo- naïve and ...
Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.
Breast Cancer Research (Online Edition) 17(1):87 (2015)
Influence of biospecimen variables on proteomic biomarkers in breast cancer.
Clinical Cancer Research 20(14):3870 (2014)
PI3K/Akt/mTOR signaling is being actively pursued as a therapeutic target for breast cancer. We sought to determine if tumor heterogeneity and biospecimen variables affect the evaluation of PI3K/Akt/mTOR pathway markers.
Intraoperative image-guided core-needle biopsies (CNB), and central and per...
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Nature Medicine 20(7):715 (2014)
Despite the fact that genitourinary defects are among the most common birth defects in newborns, little is known about their etiology. Here we analyzed children born with congenital genitourinary tract masculinization disorders by array-comparative genomic hybridization, which revealed in 1.35% ...
Loss of LRIG1 locus increases risk of early and late relapse of stage I/II breast cancer.
Cancer Research 74(11):2928 (2014)
Gains and losses at chromosome 3p12-21 are common in breast tumors and associated with patient outcomes. We hypothesized that the LRIG1 gene at 3p14.1, whose product functions in ErbB-family member degradation, is a critical tumor modifier at this locus. We analyzed 971 stage I/II breast tumors ...
Concordance of genomic alterations between primary and recurrent breast cancer.
Molecular Cancer Therapeutics 13(5):1382 (2014)
There is growing interest in delivering genomically informed cancer therapy. Our aim was to determine the concordance of genomic alterations between primary and recurrent breast cancer. Targeted next-generation sequencing was performed on formalin-fixed paraffin-embedded (FFPE) samples, profilin...
Y-chromosome microdeletions are not associated with SHOX haploinsufficiency.
Human Reproduction 29(5):1113 (2014)
Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1.
PLoS ONE 9(9):e107028 (2014)
Normal development of the genitourinary (GU) tract is a complex process that frequently goes awry. In male children the most frequent congenital GU anomalies are cryptorchidism (1-4%), hypospadias (1%) and micropenis (0.35%). Bladder exstrophy and epispadias complex (BEEC) (1∶47000) occurs less ...
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.
FASEB Journal 28(1):364 (2014)
A major limitation of exogenous vitamin D3 administration for the treatment of prostate cancer is the marginal, if any, clinical efficacy. We dissected the basis for the resistance to the vitamin D3 antitumor properties and specifically examined the effect of its major catabolic enzyme, CYP24A1,...
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer.
Breast Cancer Research and Treatment 143(1):189 (2014)
The aim of this study is to identify and validate copy number aberrations in early-stage primary breast tumors associated with bone or non-bone metastasis. Whole-genome molecular inversion probe arrays were used to evaluate copy number imbalances (CNIs) in breast tumors from 960 early-stage pati...
Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.
Breast Cancer Research (Online Edition) 16(6):3417 (2014)
Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In this study, we hypothesized that elafin is downregulated during breast and ovarian tumorigenesis.
We examined elafin expression by imm...
A review of suspected cases of driving under the influence of drugs (DUID) involved in traffic accidents in Istanbul (Turkey).
Journal of Forensic and Legal Medicine 20(6):626 (2013)
Nowadays traffic accidents, which have high mortality and morbidity, are an important public health problem. The association between the use of alcohol and/or drugs by drivers and the increased risk of traffic accidents with a high risk of death and injury has been well described in the literatu...
Dynein Light Chain 1, a p21-Activated Kinase 1-Interacting Substrate, Promotes Cancerous Phenotypes
Cancer Cell 23(3):421 (2013)