1. The Authors Reply.

    Kidney International 88(1):196 (2015) PMID 26126096

  2. A20 expression in dendritic cells protects mice from LPS-induced mortality.

    European Journal of Immunology 45(3):818 (2015) PMID 25472594

    DCs contribute to immune homeostasis under physiological conditions and regulate the immune activation during infection. The deubiquitinase A20 inhibits the activation of NF-κB-dependent immune reactions, and prevents the hyperactivation of DCs under steady-state conditions. However, the role of...
  3. A20 expression in dendritic cells protects mice from LPS-induced mortality.

    European Journal of Immunology 45(3):818 (2015) PMID 25472594

    DCs contribute to immune homeostasis under physiological conditions and regulate the immune activation during infection. The deubiquitinase A20 inhibits the activation of NF-κB-dependent immune reactions, and prevents the hyperactivation of DCs under steady-state conditions. However, the role of...
  4. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

    Kidney International 87(1):74 (2015) PMID 25075770 PMCID PMC4284813

    Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic neph...
  5. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.

    Nature Communications 6:6496 (2015) PMID 25754093

    Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding pr...
  6. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

    Kidney International 87(1):74 (2015) PMID 25075770 PMCID PMC4284813

    Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic neph...
  7. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

    Kidney International 87(1):74 (2015) PMID 25075770

    Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic neph...
  8. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

    Kidney International 87(1):74 (2015) PMID 25075770 PMCID PMC4284813

    Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic neph...
  9. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.

    Nature Communications 6:6496 (2015) PMID 25754093 PMCID PMC4366504

    Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding pr...
  10. Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.

    Journal of Clinical Oncology 32(30):3421 (2014) PMID 25225421

    Steroid-refractory graft-versus-host disease (GVHD) is a major and often fatal complication after allogeneic stem-cell transplantation (alloSCT). Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and...
  11. Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.

    Journal of Clinical Oncology 32(30):3421 (2014) PMID 25225421

    Steroid-refractory graft-versus-host disease (GVHD) is a major and often fatal complication after allogeneic stem-cell transplantation (alloSCT). Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and...
  12. Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.

    Journal of Clinical Oncology 32(30):3421 (2014) PMID 25225421

    Steroid-refractory graft-versus-host disease (GVHD) is a major and often fatal complication after allogeneic stem-cell transplantation (alloSCT). Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and...
  13. Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study.

    American Journal of Clinical Nutrition 100(3):891 (2014) PMID 25057154

    The inverse association between coffee consumption and the risk of type 2 diabetes (T2D) is well established; however, little is known about potential mediators of this association. We aimed to investigate the association between coffee consumption and diabetes-related biomarkers and their poten...
  14. Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study.

    American Journal of Clinical Nutrition 100(3):891 (2014) PMID 25057154

    The inverse association between coffee consumption and the risk of type 2 diabetes (T2D) is well established; however, little is known about potential mediators of this association. We aimed to investigate the association between coffee consumption and diabetes-related biomarkers and their poten...
  15. Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study.

    American Journal of Clinical Nutrition 100(3):891 (2014) PMID 25057154

    The inverse association between coffee consumption and the risk of type 2 diabetes (T2D) is well established; however, little is known about potential mediators of this association. We aimed to investigate the association between coffee consumption and diabetes-related biomarkers and their poten...
  16. Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

    International Journal of Cardiology 176(1):139 (2014) PMID 25085378

    Coagulation and prothrombotic potential have genuinely been associated with increased cardiovascular risk. However, not all studies in this regard are conclusive. Some clinical trials have shown an increased frequency of cardiovascular complications in patients receiving direct thrombin inhibito...
  17. Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

    Haematologica 99(6):e90 (2014) PMID 24633870 PMCID PMC4040902

  18. Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

    Haematologica 99(6):e90 (2014) PMID 24633870 PMCID PMC4040902

  19. Activated protein C based therapeutic strategies in chronic diseases.

    Thrombosis and Haemostasis 111(4):610 (2014) PMID 24652581

    Activated protein C (aPC) is a natural anticoagulant and a potent anti-inflammatory and cytoprotective agent. At the expense of increased bleeding risk aPC has been used - with some success - in sepsis. The design of cytoprotective-selective aPC variants circumvents this limitation of increased ...
  20. Activated protein C based therapeutic strategies in chronic diseases.

    Thrombosis and Haemostasis 111(4):610 (2014) PMID 24652581

    Activated protein C (aPC) is a natural anticoagulant and a potent anti-inflammatory and cytoprotective agent. At the expense of increased bleeding risk aPC has been used - with some success - in sepsis. The design of cytoprotective-selective aPC variants circumvents this limitation of increased ...