1. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  2. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  3. A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

    Cell 160(5):1013 (2015)

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases ...
  4. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  5. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  6. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  7. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  8. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  9. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916 PMCID PMC4389904

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  10. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis.

    Cell Stem Cell 16(1):39 (2015) PMID 25467916

    Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells...
  11. H3K4me3 breadth is linked to cell identity and transcriptional consistency.

    Cell 158(3):673 (2014) PMID 25083876 PMCID PMC4137894

    Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity an...
  12. H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency

    Cell 158(3):673 (2014)

    Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the i...
  13. H3K4me3 breadth is linked to cell identity and transcriptional consistency.

    Cell 158(3):673 (2014) PMID 25083876 PMCID PMC4137894

    Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity an...
  14. H3K4me3 breadth is linked to cell identity and transcriptional consistency.

    Cell 158(3):673 (2014) PMID 25083876 PMCID PMC4137894

    Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity an...
  15. H3K4me3 breadth is linked to cell identity and transcriptional consistency.

    Cell 158(3):673 (2014) PMID 25083876 PMCID PMC4137894

    Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity an...
  16. Males shorten the life span of C. elegans hermaphrodites via secreted compounds.

    Science 343(6170):541 (2014) PMID 24292626 PMCID PMC4126796

    How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites....
  17. Males shorten the life span of C. elegans hermaphrodites via secreted compounds.

    Science 343(6170):541 (2014) PMID 24292626 PMCID PMC4126796

    How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites....
  18. H3K4me3 breadth is linked to cell identity and transcriptional consistency

    Cell (2013)

    - Broad H3K4me3 domains mark cell identity genes and can be used as a discovery tool - Broad H3K4me3 domains are a distinct entity defined by specific PolII regula...
  19. H3K4me3 breadth is linked to cell identity and transcriptional consistency

    Cell (2013)

    - Broad H3K4me3 domains mark cell identity genes and can be used as a discovery tool - Broad H3K4me3 domains are a distinct entity defined by specific PolII regula...
  20. H3K4me3 breadth is linked to cell identity and transcriptional consistency

    Cell (2013)

    - Broad H3K4me3 domains mark cell identity genes and can be used as a discovery tool - Broad H3K4me3 domains are a distinct entity defined by specific PolII regula...