1. Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts.

    Biomaterials 33(33):8277 (2012) PMID 22906604

    Living autologous tissue engineered vascular-grafts (TEVGs) with growth-capacity may overcome the limitations of contemporary artificial-prostheses. However, the multi-step in vitro production of TEVGs requires extensive ex vivo cell-manipulations with unknown effects on functionality and qualit...
  2. Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts

    Biomaterials 33(33):8277 (2012)

    Living autologous tissue engineered vascular-grafts (TEVGs) with growth-capacity may overcome the limitations of contemporary artificial-prostheses. However, the multi-step in vitro production of TEVGs requires extensive ex vivo cell-manipulations with unknown effects on functionality ...
  3. 3D microtissue formation of undifferentiated bone marrow mesenchymal stem cells leads to elevated apoptosis.

    Tissue Engineering, Part A: Tissue Engineering 18(7-8):692 (2012) PMID 21988679

    Current implantation formats to deliver bone marrow-derived mesenchymal stem cells (MSCs) to the site of myocardial injury resulted only in limited cell retention and integration. As an alternative concept to single cell transplantation, we investigated the fate of cell tracker-labeled syngenic ...
  4. Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines.

    Journal of Allergy and Clinical Immunology 128(6):1286 (2011) PMID 21807405

    Antihistamines are considered safe and used worldwide against allergy, pruritus, nausea, and cough and as sleeping aids. Nonetheless, a growing number of reports suggest that antihistamines also have immunoregulatory functions. We examined the extent and by what potential mechanisms histamine-1-...
  5. Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase–dependent proinflammatory cytokines

    Journal of Allergy and Clinical Immunology 128(6):1286 (2011)

    Background Antihistamines are considered safe and used worldwide against allergy, pruritus, nausea, and cough and as sleeping aids. Nonetheless, a growing number of reports suggest that antihistamines also have immunoregulatory functions.
  6. Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation.

    Haematologica 96(1):119 (2011) PMID 20934999 PMCID PMC3012775

    The possibility that allogeneic hematopoietic stem cell transplantation performed across the ABO blood group-barrier is associated with an increase of graft-versus-host disease, in particular endothelial damage, has not been elucidated so far. For this reason, we investigated the level of endoth...
  7. Minimally-invasive implantation of living tissue engineered heart valves: a comprehensive approach from autologous vascular cells to stem cells.

    Journal of the American College of Cardiology 56(6):510 (2010) PMID 20670763

    The aim of this study was to demonstrate the feasibility of combining the novel heart valve replacement technologies of: 1) tissue engineering; and 2) minimally-invasive implantation based on autologous cells and composite self-expandable biodegradable biomaterials. Minimally-invasive valve repl...
  8. A novel concept for scaffold-free vessel tissue engineering: self-assembly of microtissue building blocks.

    Journal of Biotechnology 148(1):46 (2010) PMID 20223267

    Current scientific attempts to generate in vitro tissue-engineered living blood vessels (TEBVs) show substantial limitations, thereby preventing routine clinical use. In the present report, we describe a novel biotechnology concept to create living small diameter TEBV based exclusively on microt...
  9. A novel concept for scaffold-free vessel tissue engineering: Self-assembly of microtissue building blocks

    Journal of Biotechnology 148(1):46 (2010)

    Current scientific attempts to generate in vitro tissue-engineered living blood vessels (TEBVs) show substantial limitations, thereby preventing routine clinical use. In the present report, we describe a novel biotechnology concept to create living small diameter TEBV based exclusive...
  10. Minimally-Invasive Implantation of Living Tissue Engineered Heart Valves:A Comprehensive Approach From Autologous Vascular Cells to Stem Cells

    Journal of the American College of Cardiology 56(6):510 (2010)

    Objectives The aim of this study was to demonstrate the feasibility of combining the novel heart valve replacement technologies of: 1) tissue engineering; and 2) minimally-invasive implantation based on autologous cells and composite self-expandable biodegradable biomaterials.
  11. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions.

    The American Journal of Pathology 174(6):2310 (2009) PMID 19435787 PMCID PMC2684195

    Phagocytosis is essential for the removal of photoreceptor debris following retinal injury. We used two mouse models, mice injected with green fluorescent protein-labeled bone marrow cells or green fluorescent protein-labeled microglia, to study the origin and activation patterns of phagocytic c...
  12. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

    PNAS 106(17):7107 (2009) PMID 19351895 PMCID PMC2678456

    Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow....
  13. Impaired antibody response causes persistence of prototypic T cell-contained virus.

    PLoS Biology 7(4):e1000080 (2009) PMID 19355789 PMCID PMC2672599

    CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LC...
  14. Cooperative Phagocytes:Resident Microglia and Bone Marrow Immigrants Remove Dead Photoreceptors in Retinal Lesions

    The American Journal of Pathology 174(6):2310 (2009)

    Phagocytosis is essential for the removal of photoreceptor debris following retinal injury. We used two mouse models, mice injected with green fluorescent protein-labeled bone marrow cells or green fluorescent protein-labeled microglia, to study the origin and activation patterns of phagocy...
  15. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

    Cell Host & Microbe 4(4):362 (2008) PMID 18854240

    Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine paras...
  16. Aggravation of viral hepatitis by platelet-derived serotonin.

    Nature Medicine 14(7):756 (2008) PMID 18516052

    More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stag...
  17. Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering.

    The Journal of heart valve disease 17(4):446 (2008) PMID 18751475

    Fetal stem cells represent a promising cell source for heart valve tissue engineering. In particular, amniotic fluid-derived cells (AFDC) have been shown to lead to autologous fetal-like heart valve tissues in vitro for pediatric application. In order to expand the versatility of these cells als...
  18. PARP1 is required for adhesion molecule expression in atherogenesis.

    Cardiovascular Research 78(1):158 (2008) PMID 18093987

    Atherosclerosis is the leading cause of death in Western societies and a chronic inflammatory disease. However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme, which plays a role in acu...
  19. Differentiation of human follicular thyroid adenomas from carcinomas by gene expression profiling.

    Oncology Reports 19(2):329 (2008) PMID 18202778

    It is difficult to distinguish benign from malignant follicular thyroid tumors by histological or cytological examination. The goal of this study was to reveal gene expression variations between benign and malignant follicular lesions of the thyroid gland. We investigated gene expression profile...
  20. Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection

    Cell Host & Microbe 4(4):362 (2008)

    Anti-helminth immunity involves CD4 + T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus ( H...