1. Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor 1254 are mainly associated with the dioxin-like constituents.

    Toxicology in Vitro 29(5):876 (2015) PMID 25795401

    The polychlorinated biphenyl (PCB) mixture Aroclor 1254 alters bone tissue properties. However, the mechanisms responsible for the observed effects have not yet been clarified. This study compared the effect of Aroclor 1254 on the expression of osteoblast differentiation markers in MC3T3-E1 cell...
  2. Neuroinflammation in Alzheimer's disease.

    The Lancet Neurology 14(4):388 (2015) PMID 25792098

    Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and t...
  3. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

    Cell Reports 10(9):1626 (2015)

    Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia’s inflammatory response is fully acknowledged, little is known about endogenous ligands th...
  4. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

    Cell Reports 10(9):1626 (2015)

    Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia’s inflammatory response is fully acknowledged, little is known about endogenous ligands th...
  5. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy.

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unchecked autophagy activity causes...
  6. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Background Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unch...
  7. Accidentally enucleating autophagy.

    Nature Reviews: Molecular Cell Biology 16(1):4 (2015) PMID 25466865

  8. Accidentally enucleating autophagy.

    Nature Reviews: Molecular Cell Biology 16(1):4 (2015) PMID 25466865

  9. Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism.

    Journal of neuroinflammation 12(1):5 (2015) PMID 25586882 PMCID PMC4302615

    We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microglia in the ventral mesencephalon from subjects with Parkinson...
  10. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  11. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  12. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  13. Preservation of aortic root architecture and properties using a detergent-enzymatic perfusion protocol.

    Biomaterials 35(6):1907 (2014) PMID 24321707

    Aortic valve degeneration and dysfunction is one of the leading causes for morbidity and mortality. The conventional heart-valve prostheses have significant limitations with either life-long anticoagulation therapeutic associated bleeding complications (mechanical valves) or limited durability (...
  14. Preservation of aortic root architecture and properties using a detergent-enzymatic perfusion protocol.

    Biomaterials 35(6):1907 (2014) PMID 24321707

    Aortic valve degeneration and dysfunction is one of the leading causes for morbidity and mortality. The conventional heart-valve prostheses have significant limitations with either life-long anticoagulation therapeutic associated bleeding complications (mechanical valves) or limited durability (...
  15. Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

    Nature Communications 5:3562 (2014) PMID 24736316

    A tissue-engineered oesophageal scaffold could be very useful for the treatment of pediatric and adult patients with benign or malignant diseases such as carcinomas, trauma or congenital malformations. Here we decellularize rat oesophagi inside a perfusion bioreactor to create biocompatible biol...
  16. The return of the nucleus: transcriptional and epigenetic control of autophagy.

    Nature Reviews: Molecular Cell Biology 15(1):65 (2014) PMID 24326622

    Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigene...
  17. The return of the nucleus: transcriptional and epigenetic control of autophagy.

    Nature Reviews: Molecular Cell Biology 15(1):65 (2014) PMID 24326622

    Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigene...
  18. Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

    Nature Communications 5:3562 (2014) PMID 24736316 PMCID PMC4354271

    A tissue-engineered oesophageal scaffold could be very useful for the treatment of pediatric and adult patients with benign or malignant diseases such as carcinomas, trauma or congenital malformations. Here we decellularize rat oesophagi inside a perfusion bioreactor to create biocompatible biol...
  19. Histone post-translational modifications regulate autophagy flux and outcome.

    Autophagy 9(10):1621 (2013) PMID 23934085

    Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily c...
  20. Histone post-translational modifications regulate autophagy flux and outcome.

    Autophagy 9(10):1621 (2013) PMID 23934085

    Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily c...