1. Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.

    Brain 138(Pt 6):1568 (2015) PMID 25863355

    Spinal neurodegeneration is an important determinant of disability progression in patients with primary progressive multiple sclerosis. Advanced imaging techniques, such as single-voxel (1)H-magnetic resonance spectroscopy and q-space imaging, have increased pathological specificity for neurodeg...
  2. Training balance with opto-kinetic stimuli in the home: a randomized controlled feasibility study in people with pure cerebellar disease.

    Clinical Rehabilitation 29(2):143 (2015) PMID 25082955

    To investigate the feasibility of a randomized controlled trial of a home-based balance intervention for people with cerebellar ataxia. A randomized controlled trial design. Intervention and assessment took place in the home environment. A total of 12 people with spinocerebellar ataxia type 6 we...
  3. Training balance with opto-kinetic stimuli in the home: a randomized controlled feasibility study in people with pure cerebellar disease.

    Clinical Rehabilitation 29(2):143 (2015) PMID 25082955

    To investigate the feasibility of a randomized controlled trial of a home-based balance intervention for people with cerebellar ataxia. A randomized controlled trial design. Intervention and assessment took place in the home environment. A total of 12 people with spinocerebellar ataxia type 6 we...
  4. Neuromechanical interference of posture on movement: evidence from Alexander technique teachers rising from a chair.

    Journal of Neurophysiology 112(3):719 (2014) PMID 25085609 PMCID PMC4122698

    While Alexander technique (AT) teachers have been reported to stand up by shifting weight gradually as they incline the trunk forward, healthy untrained (HU) adults appear unable to rise in this way. This study examines the hypothesis that HU have difficulty rising smoothly, and that this diffic...
  5. Neuromechanical interference of posture on movement: evidence from Alexander technique teachers rising from a chair.

    Journal of Neurophysiology 112(3):719 (2014) PMID 25085609 PMCID PMC4122698

    While Alexander technique (AT) teachers have been reported to stand up by shifting weight gradually as they incline the trunk forward, healthy untrained (HU) adults appear unable to rise in this way. This study examines the hypothesis that HU have difficulty rising smoothly, and that this diffic...
  6. Violation of the craniocentricity principle for vestibularly evoked balance responses under conditions of anisotropic stability.

    Journal of Neuroscience 34(22):7696 (2014) PMID 24872573 PMCID PMC4035529

    The balance response direction to electrically evoked vestibular perturbation is closely tied to head orientation. Such craniocentric response organization is expected of a simple error correction process. Here we ask whether this is maintained when the body is made more stable, but with the sta...
  7. Violation of the craniocentricity principle for vestibularly evoked balance responses under conditions of anisotropic stability.

    Journal of Neuroscience 34(22):7696 (2014) PMID 24872573 PMCID PMC4035529

    The balance response direction to electrically evoked vestibular perturbation is closely tied to head orientation. Such craniocentric response organization is expected of a simple error correction process. Here we ask whether this is maintained when the body is made more stable, but with the sta...
  8. A dynamic model of the eye nystagmus response to high magnetic fields.

    Physics in Medicine and Biology 59(3):631 (2014) PMID 24434733

    It was recently shown that high magnetic fields evoke nystagmus in human subjects with functioning vestibular systems. The proposed mechanism involves interaction between ionic currents in the endolymph of the vestibular labyrinth and the static magnetic field. This results in a Lorentz force th...
  9. A dynamic model of the eye nystagmus response to high magnetic fields.

    Physics in Medicine and Biology 59(3):631 (2014) PMID 24434733

    It was recently shown that high magnetic fields evoke nystagmus in human subjects with functioning vestibular systems. The proposed mechanism involves interaction between ionic currents in the endolymph of the vestibular labyrinth and the static magnetic field. This results in a Lorentz force th...
  10. Subcortical visuomotor control of human limb movement.

    Advances in Experimental Medicine and Biology 826:55 (2014) PMID 25330885

  11. Subcortical visuomotor control of human limb movement.

    Advances in Experimental Medicine and Biology 826:55 (2014) PMID 25330885

  12. Subcortical visuomotor control of human limb movement.

    Advances in Experimental Medicine and Biology 826:55 (2014) PMID 25330885

  13. Asymmetry of balance responses to monaural galvanic vestibular stimulation in subjects with vestibular schwannoma

    Clinical Neurophysiology 124(9):1835 (2013)

    • Galvanic vestibular stimulation is used to study vestibulospinal asymmetry. • Responses to monaural stimulation of left and right healthy ears are not different....
  14. Asymmetry of balance responses to monaural galvanic vestibular stimulation in subjects with vestibular schwannoma.

    Clinical Neurophysiology 124(9):1835 (2013) PMID 23643313 PMCID PMC3745707

    We investigated the potential of galvanic vestibular stimulation (GVS) to quantify lateralised asymmetry of the vestibulospinal pathways by measuring balance responses to monaural GVS in 10 subjects with vestibular schwannoma and 22 healthy control subjects. Subjects standing without vision were...
  15. How the vestibular system interacts with somatosensory perception: a sham-controlled study with galvanic vestibular stimulation.

    Neuroscience Letters 550:35 (2013) PMID 23827220 PMCID PMC3988931

    The vestibular system has widespread interactions with other sensory modalities. Here we investigate whether vestibular stimulation modulates somatosensory function, by assessing the ability to detect faint tactile stimuli to the fingertips of the left and right hand with or without galvanic ves...
  16. How the vestibular system interacts with somatosensory perception: a sham-controlled study with galvanic vestibular stimulation.

    Neuroscience Letters 550:35 (2013) PMID 23827220 PMCID PMC3988931

    The vestibular system has widespread interactions with other sensory modalities. Here we investigate whether vestibular stimulation modulates somatosensory function, by assessing the ability to detect faint tactile stimuli to the fingertips of the left and right hand with or without galvanic ves...
  17. How the vestibular system interacts with somatosensory perception: A sham-controlled study with galvanic vestibular stimulation

    Neuroscience Letters 550:35 (2013)

    • Left anodal galvanic vestibular stimulation increased tactile sensitivity. • No effects induced by sham stimulation or right anodal galvanic vestibular stimulati...
  18. Step by step: a proof of concept study of C-Mill gait adaptability training in the chronic phase after stroke.

    Journal of Rehabilitation Medicine 45(7):616 (2013) PMID 23811818

    To evaluate the concept of C-Mill gait adaptability training. Pre- and post-intervention assessments. Sixteen community-dwelling persons in the chronic phase after stroke (mean age 54.8 years). Participants received 10 sessions (1 h per session, for 5-6 weeks) of gait adaptability training on an...
  19. Step by step: a proof of concept study of C-Mill gait adaptability training in the chronic phase after stroke.

    Journal of Rehabilitation Medicine 45(7):616 (2013) PMID 23811818

    To evaluate the concept of C-Mill gait adaptability training. Pre- and post-intervention assessments. Sixteen community-dwelling persons in the chronic phase after stroke (mean age 54.8 years). Participants received 10 sessions (1 h per session, for 5-6 weeks) of gait adaptability training on an...
  20. Stance instability in spinocerebellar ataxia type 6.

    Movement Disorders 28(4):510 (2013) PMID 23143967

    Balance impairment is a principal symptom of cerebellar disease, but is poorly understood partly because subjects with heterogenous cerebellar and extracerebellar lesions have often been studied. Spinocerebellar ataxia type 6 (SCA6) provides an opportunity to understand balance dysfunction assoc...