1. Murine islet allograft tolerance upon blockade of the B-lymphocyte stimulator, BLyS/BAFF.

    Transplantation 93(7):676 (2012) PMID 22262127

    Immunologic rejection is a major barrier to successful long-term outcomes in clinical transplantation. The importance of B lymphocytes-and their secretory products, alloantibodies-in the pathogenesis of allograft rejection is accepted. Furthermore, it is now clear that the dominant regulator of ...
  2. Murine islet allograft tolerance upon blockade of the B-lymphocyte stimulator, BLyS/BAFF.

    Transplantation 93(7):676 (2012) PMID 22262127

    Immunologic rejection is a major barrier to successful long-term outcomes in clinical transplantation. The importance of B lymphocytes-and their secretory products, alloantibodies-in the pathogenesis of allograft rejection is accepted. Furthermore, it is now clear that the dominant regulator of ...
  3. Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model.

    Endocrinology 153(4):1673 (2012) PMID 22355065 PMCID PMC3320262

    Islet amyloid is hypothesized to play a role in nonimmunologic transplanted islet graft loss. We performed a quantitative histologic analysis of liver biopsies from intrahepatic islet grafts transplanted in streptozotocin-induced diabetic cynomolgus macaques. Seven animals treated with antithymo...
  4. Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model.

    Endocrinology 153(4):1673 (2012) PMID 22355065 PMCID PMC3320262

    Islet amyloid is hypothesized to play a role in nonimmunologic transplanted islet graft loss. We performed a quantitative histologic analysis of liver biopsies from intrahepatic islet grafts transplanted in streptozotocin-induced diabetic cynomolgus macaques. Seven animals treated with antithymo...
  5. Acquisition of humoral transplantation tolerance upon de novo emergence of B lymphocytes.

    Journal of Immunology 186(1):614 (2011) PMID 21084661

    A major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for acquisition of self-tolerance can be harnessed to induce humoral unresponsiveness to transplanted alloantigens. In the ...
  6. Acquisition of humoral transplantation tolerance upon de novo emergence of B lymphocytes.

    Journal of Immunology 186(1):614 (2011) PMID 21084661

    A major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for acquisition of self-tolerance can be harnessed to induce humoral unresponsiveness to transplanted alloantigens. In the ...
  7. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice.

    Journal of Immunology 181(11):8133 (2008) PMID 19018006 PMCID PMC2586964

    B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice. Previous studies established that a lymphopenic transitional (TR) B cell compartment reduces the competitive constraint on the entry of newly emerging TR B cells into the splenic follicle (FO), thereby disrupting...
  8. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice.

    Journal of Immunology 181(11):8133 (2008) PMID 19018006 PMCID PMC2586964

    B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice. Previous studies established that a lymphopenic transitional (TR) B cell compartment reduces the competitive constraint on the entry of newly emerging TR B cells into the splenic follicle (FO), thereby disrupting...
  9. CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis.

    Journal of Immunology 180(2):833 (2008) PMID 18178822

    We have examined processes leading to the spontaneous development of autoimmune inflammatory arthritis in transgenic mice containing CD4+ T cells targeted to a nominal Ag (hemagglutinin (HA)) and coexpressing HA driven by a MHC class II promoter. Despite being subjected to multiple tolerance mec...
  10. CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis.

    Journal of Immunology 180(2):833 (2008) PMID 18178822

    We have examined processes leading to the spontaneous development of autoimmune inflammatory arthritis in transgenic mice containing CD4+ T cells targeted to a nominal Ag (hemagglutinin (HA)) and coexpressing HA driven by a MHC class II promoter. Despite being subjected to multiple tolerance mec...
  11. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

    Nature Medicine 13(11):1295 (2007) PMID 17965721

    We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
  12. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

    Nature Medicine 13(11):1295 (2007) PMID 17965721

    We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
  13. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.

    Journal of Immunology 177(11):7715 (2006) PMID 17114442

    Acute allograft rejection requires the activation of alloreactive CD4 T cells. Despite the capacity of B cells to act as potent APCs capable of activating CD4 T cells in vivo, their role in the progression of acute allograft rejection was unclear. To determine the contribution of B cell APC func...
  14. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.

    Journal of Immunology 177(11):7715 (2006) PMID 17114442

    Acute allograft rejection requires the activation of alloreactive CD4 T cells. Despite the capacity of B cells to act as potent APCs capable of activating CD4 T cells in vivo, their role in the progression of acute allograft rejection was unclear. To determine the contribution of B cell APC func...
  15. A glucose sensor role for glucokinase in anterior pituitary cells.

    Diabetes 55(7):1923 (2006) PMID 16804059

    Enzymatic activity of glucokinase was demonstrated, quantitated, and characterized kinetically in rat and mouse pituitary extracts using a highly specific and sensitive spectrometric assay. A previously proposed hypothesis that the glucokinase gene might be expressed in the pituitary corticotrop...
  16. A glucose sensor role for glucokinase in anterior pituitary cells.

    Diabetes 55(7):1923 (2006) PMID 16804059

    Enzymatic activity of glucokinase was demonstrated, quantitated, and characterized kinetically in rat and mouse pituitary extracts using a highly specific and sensitive spectrometric assay. A previously proposed hypothesis that the glucokinase gene might be expressed in the pituitary corticotrop...
  17. T-reg mediated suppression of the allograft response in the draining lymph node.

    Transplantation 81(7):1063 (2006) PMID 16612285

    We previously demonstrated that T-regs inhibit proliferation of graft-reactive T cells in the draining lymph node (DLN), suggesting that this site may be important for regulation. TCR transgenic mice (TS1) specific for viral hemagglutinin (HA) provided antigen-specific T cells for adoptive trans...
  18. T-reg mediated suppression of the allograft response in the draining lymph node.

    Transplantation 81(7):1063 (2006) PMID 16612285

    We previously demonstrated that T-regs inhibit proliferation of graft-reactive T cells in the draining lymph node (DLN), suggesting that this site may be important for regulation. TCR transgenic mice (TS1) specific for viral hemagglutinin (HA) provided antigen-specific T cells for adoptive trans...
  19. T-regs inhibit effector T cell accumulation to prolong allograft survival

    Journal of the American College of Surgeons 201(3):S90 (2005)

  20. T-regs inhibit effector T cell accumulation to prolong allograft survival

    Journal of the American College of Surgeons 201(3):S90 (2005)