1. Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.

    Journal of Immunology 195(3):875 (2015) PMID 26116507

    Previous studies demonstrated that bone marrow-derived mesenchymal stem (stromal) cells (MSCs) reduce the severity of acute lung injury in animal models and in an ex vivo perfused human lung model. However, the mechanisms by which MSCs reduce lung injury are not well understood. In the present s...
  2. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

    Neuron 87(2):341 (2015) PMID 26119026 PMCID PMC4506220

    Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory n...
  3. CLINICAL PROBLEM-SOLVING. A Man with Fever, Cough, and Rash.

    New England Journal of Medicine 373(1):74 (2015) PMID 26132944

    A 67-year-old man with hairy-cell leukemia presented to the clinic after 3 days of fevers, night sweats, arthralgias, and an erythematous vesicular-appearing rash on his back. He had not had headache, shortness of breath, bleeding episodes, vomiting, or diarrhea.
  4. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  5. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  6. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  7. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  8. Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells.

    American Journal of Respiratory Cell and Molecu... 52(3):377 (2015) PMID 25137396

    Our previous studies showed that cigarette smokers who are exposed to wood smoke (WS) are at an increased risk for chronic bronchitis and reduced lung function. The present study was undertaken to determine the mechanisms for WS-induced adverse effects. We studied the effect of WS exposure using...
  9. Innate immunity is a key factor for the resolution of inflammation in asthma.

    European Respiratory Review 24(135):141 (2015) PMID 25726564

    The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly regulated cellular and biochemical events. Recent discoveries have highli...
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  10. Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells.

    American Journal of Respiratory Cell and Molecu... 52(3):377 (2015) PMID 25137396 PMCID PMC4370262

    Our previous studies showed that cigarette smokers who are exposed to wood smoke (WS) are at an increased risk for chronic bronchitis and reduced lung function. The present study was undertaken to determine the mechanisms for WS-induced adverse effects. We studied the effect of WS exposure using...
  11. Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells.

    American Journal of Respiratory Cell and Molecu... 52(3):377 (2015) PMID 25137396

    Our previous studies showed that cigarette smokers who are exposed to wood smoke (WS) are at an increased risk for chronic bronchitis and reduced lung function. The present study was undertaken to determine the mechanisms for WS-induced adverse effects. We studied the effect of WS exposure using...
  12. Innate immunity is a key factor for the resolution of inflammation in asthma.

    European Respiratory Review 24(135):141 (2015) PMID 25726564 PMCID PMC4490858

    The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly regulated cellular and biochemical events. Recent discoveries have highli...
  13. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

    Journal of Immunology 194(3):863 (2015) PMID 25539814 PMCID PMC4297713

    Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of murine lungs identified temporal ...
  14. Blue journal conference. Aging and susceptibility to lung disease.

    American Journal of Respiratory and Critical Ca... 191(3):261 (2015) PMID 25590812

    The aging of the population in the United States and throughout the developed world has increased morbidity and mortality attributable to lung disease, while the morbidity and mortality from other prevalent diseases has declined or remained stable. Recognizing the importance of aging in the deve...
  15. Blue journal conference. Aging and susceptibility to lung disease.

    American Journal of Respiratory and Critical Ca... 191(3):261 (2015) PMID 25590812 PMCID PMC4351581

    The aging of the population in the United States and throughout the developed world has increased morbidity and mortality attributable to lung disease, while the morbidity and mortality from other prevalent diseases has declined or remained stable. Recognizing the importance of aging in the deve...
  16. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

    Journal of Immunology 194(3):863 (2015) PMID 25539814

    Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of murine lungs identified temporal ...
  17. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

    Journal of Immunology 194(3):863 (2015) PMID 25539814 PMCID PMC4297713

    Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of murine lungs identified temporal ...
  18. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

    Journal of Immunology 194(3):863 (2015) PMID 25539814 PMCID PMC4297713

    Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of murine lungs identified temporal ...
  19. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

    Journal of Immunology 194(3):863 (2015) PMID 25539814

    Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of murine lungs identified temporal ...
  20. A Liberian Health Care Worker with Fever

    New England Journal of Medicine 372(5):e7 (2015)

    This interactive feature presents a 52-year-old woman with fever and muscle and joint pain. She also reported the development of headache, anorexia, nausea, mild diarrhea, and mild chest pains in the preceding 1 to 2 days. Test your diagnostic and therapeutic skills at NEJM.org. ...