1. Emotion recognition in frontotemporal dementia and Alzheimer's disease: A new film-based assessment.

    Emotion 15(4):416 (2015) PMID 26010574

    Deficits in recognizing others' emotions are reported in many psychiatric and neurological disorders, including autism, schizophrenia, behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Most previous emotion recognition studies have required participants to identify...
  2. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.

    Neurology 85(1):40 (2015) PMID 26062630 PMCID PMC4501943

    Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients w...
  3. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.

    Brain 138(Pt 7):2020 (2015) PMID 25953778

    Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying amyloid-β positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B. A variety of thresholds have been applied in the...
  4. The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

    Journal of Neuroscience 35(25):9315 (2015) PMID 26109656 PMCID PMC4478251

    Mutations in the human progranulin gene resulting in protein haploinsufficiency cause frontotemporal lobar degeneration with TDP-43 inclusions. Although progress has been made in understanding the normal functions of progranulin and TDP-43, the molecular interactions between these proteins remai...
  5. Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.

    Journal of Geriatric Psychiatry and Neurology 28(2):99 (2015) PMID 25342578 PMCID PMC4408221

    Several clinical studies point to a high prevalence of psychotic symptoms in frontotemporal dementia associated with C9ORF72 mutations, but clinicopathological studies addressing the association between C9ORF72 mutations and delusions are lacking. Seventeen patients with pathologically proven fr...
  6. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study.

    Alzheimer's & Dementia 11(6):600 (2015) PMID 25130657 PMCID PMC4329112

    Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Blood exosomes obtained at one time-point from patients with AD (n = 57) or frontotemporal dementia (FTD) (n = 16), and at two ...
  7. The Chinese Verbal Learning Test specifically assesses hippocampal state.

    American Journal of Alzheimer's Disease and Oth... 30(4):412 (2015) PMID 25270640 PMCID PMC4379122

    Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to determine whether memory consolidation as measured by the ChVLT was specifically associated with hippocampal volume in patients with cognitive impairme...
  8. Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

    JAMA 313(19):1939 (2015) PMID 25988463 PMCID PMC4517678

    Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia. To use individual participa...
  9. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

    JAMA Neurology 72(4):414 (2015) PMID 25706306 PMCID PMC4397175

    Previous studies have indicated a heritable component of the etiology of neurodegenerative diseases such as Alzheimer disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). However, few have examined the contribution of low-frequency coding variants on a genome-wi...
  10. Case records of the Massachusetts General Hospital. Case 9-2015. A 31-year-old man with personality changes and progressive neurologic decline.

    New England Journal of Medicine 372(12):1151 (2015) PMID 25785973

    A 31-year-old man was seen in the neurology clinic because of personality changes and neurologic decline of 3 years' duration. Previous imaging studies showed mild atrophy in the frontal lobes. He could not speak or follow commands. Additional diagnostic testing was performed. ...
  11. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730 PMCID PMC4256124

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...
  12. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...
  13. Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia.

    Cortex 64:55 (2015) PMID 25461707 PMCID PMC4346386

    Positive emotions foster social relationships and motivate thought and action. Dysregulation of positive emotion may give rise to debilitating clinical symptomatology such as mania, risk-taking, and disinhibition. Neuroanatomically, there is extensive evidence that the left hemisphere of the bra...
  14. Variation in longevity gene KLOTHO is associated with greater cortical volumes.

    Annals of clinical and translational neurology 2(3):215 (2015) PMID 25815349 PMCID PMC4369272

    Identifying genetic variation associated with brain structures in aging may elucidate new biologic mechanisms underlying resilience to cognitive decline. We investigated whether carrying one copy of the protective haplotype "KL-VS" in longevity gene KLOTHO (KL) is associated with greater gray ma...
  15. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730 PMCID PMC4256124

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...
  16. Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia.

    Cortex 64:55 (2015) PMID 25461707 PMCID PMC4346386

    Positive emotions foster social relationships and motivate thought and action. Dysregulation of positive emotion may give rise to debilitating clinical symptomatology such as mania, risk-taking, and disinhibition. Neuroanatomically, there is extensive evidence that the left hemisphere of the bra...
  17. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730 PMCID PMC4256124

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...
  18. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730 PMCID PMC4256124

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...
  19. Criminal behavior in frontotemporal dementia and Alzheimer disease.

    JAMA Neurology 72(3):295 (2015) PMID 25559744

    Neurodegenerative diseases can cause dysfunction of neural structures involved in judgment, executive function, emotional processing, sexual behavior, violence, and self-awareness. Such dysfunctions can lead to antisocial and criminal behavior that appears for the first time in the adult or midd...
  20. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

    Journal of Neurology, Neurosurgery & Psychiatry 86(3):244 (2015) PMID 24899730 PMCID PMC4256124

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in ...