1. The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

    Cell 160(5):1027 (2015)

  2. The cellular and molecular basis of direction selectivity of Aδ-LTMRs.

    Cell 159(7):1640 (2014) PMID 25525881 PMCID PMC4297767

    The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral ...
  3. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  4. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  5. Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice.

    Journal of Neurophysiology 103(3):1385 (2010) PMID 20071635 PMCID PMC2887619

    Cutaneous myelinated nociceptors are known to exhibit considerable heterogeneity in their response to noxious heat. In the present experiments, we studied heat sensitivity among myelinated nociceptors during early postnatal life to determine whether this heterogeneity is correlated with other ph...
  6. Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice.

    Journal of Neurophysiology 103(3):1385 (2010) PMID 20071635 PMCID PMC2887619

    Cutaneous myelinated nociceptors are known to exhibit considerable heterogeneity in their response to noxious heat. In the present experiments, we studied heat sensitivity among myelinated nociceptors during early postnatal life to determine whether this heterogeneity is correlated with other ph...
  7. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.

    Nature 462(7273):651 (2009) PMID 19915548 PMCID PMC2810205

    Mechanical pain contributes to the morbidity associated with inflammation and trauma, but primary sensory neurons that convey the sensation of acute and persistent mechanical pain have not been identified. Dorsal root ganglion (DRG) neurons transmit sensory information to the spinal cord using t...
  8. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.

    Nature 462(7273):651 (2009) PMID 19915548 PMCID PMC2810205

    Mechanical pain contributes to the morbidity associated with inflammation and trauma, but primary sensory neurons that convey the sensation of acute and persistent mechanical pain have not been identified. Dorsal root ganglion (DRG) neurons transmit sensory information to the spinal cord using t...
  9. Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice.

    Journal of Comparative Neurology 508(3):500 (2008) PMID 18335545 PMCID PMC2664515

    It is widely thought that, after peripheral injury, some low-threshold mechanoreceptive (LTMR) afferents "sprout" into pain-specific laminae (I-II) of the dorsal horn and are responsible for chronic pain states such as mechanical allodynia. Although recent studies have questioned this hypothesis...
  10. Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice.

    Journal of Comparative Neurology 508(3):500 (2008) PMID 18335545 PMCID PMC2664515

    It is widely thought that, after peripheral injury, some low-threshold mechanoreceptive (LTMR) afferents "sprout" into pain-specific laminae (I-II) of the dorsal horn and are responsible for chronic pain states such as mechanical allodynia. Although recent studies have questioned this hypothesis...
  11. TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat.

    The Journal of Pain 9(4):298 (2008) PMID 18226966 PMCID PMC2372162

    In the present study, a murine ex vivo somatosensory system preparation was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of mechanically insensitive unmyeli...
  12. TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat.

    The Journal of Pain 9(4):298 (2008) PMID 18226966 PMCID PMC2372162

    In the present study, a murine ex vivo somatosensory system preparation was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of mechanically insensitive unmyeli...
  13. TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat.

    The Journal of Pain 9(4):298 (2008) PMID 18226966 PMCID PMC2372162

    In the present study, a murine ex vivo somatosensory system preparation was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of mechanically insensitive unmyeli...
  14. Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa.

    Journal of Neuroscience 28(9):2006 (2008) PMID 18305235

    The substantia gelatinosa (SG) of the dorsal horn of the spinal cord is a recipient zone for unmyelinated sensory neurons in adults. Recent studies of the central anatomy of physiologically identified skin sensory neurons in neonatal mice have shown that this region also receives substantial inp...
  15. Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa.

    Journal of Neuroscience 28(9):2006 (2008) PMID 18305235

    The substantia gelatinosa (SG) of the dorsal horn of the spinal cord is a recipient zone for unmyelinated sensory neurons in adults. Recent studies of the central anatomy of physiologically identified skin sensory neurons in neonatal mice have shown that this region also receives substantial inp...
  16. TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

    The Journal of Pain 9(4):298 (2008)

    In the present study, a murine ex vivo somatosensory system preparation was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of mechanically insensitive un...
  17. Central and peripheral anatomy of slowly adapting type I low-threshold mechanoreceptors innervating trunk skin of neonatal mice.

    Journal of Comparative Neurology 505(5):547 (2007) PMID 17924532

    Despite intensive study, our understanding of the neuronal structures responsible for transducing the broad spectrum of environmental energies that impinge upon the skin has rested on inference and conjecture. This major shortcoming motivated the development of ex vivo somatosensory system prepa...
  18. Central and peripheral anatomy of slowly adapting type I low-threshold mechanoreceptors innervating trunk skin of neonatal mice.

    Journal of Comparative Neurology 505(5):547 (2007) PMID 17924532

    Despite intensive study, our understanding of the neuronal structures responsible for transducing the broad spectrum of environmental energies that impinge upon the skin has rested on inference and conjecture. This major shortcoming motivated the development of ex vivo somatosensory system prepa...
  19. Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties.

    Journal of Neurophysiology 98(2):668 (2007) PMID 17537905

    Recent combined analyses of the structural, functional, and molecular attributes of individual skin sensory neurons using semi-intact in vitro preparations from mice have provided a wealth of novel insights into nociceptor biology. How these findings translate to more natural conditions neverthe...
  20. Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties.

    Journal of Neurophysiology 98(2):668 (2007) PMID 17537905

    Recent combined analyses of the structural, functional, and molecular attributes of individual skin sensory neurons using semi-intact in vitro preparations from mice have provided a wealth of novel insights into nociceptor biology. How these findings translate to more natural conditions neverthe...