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  1. Effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes and estrogen receptor α in rat hippocampus

    European Journal of Pharmacology 634(1):192 (2010) PMID 20193677

    The aim of the present study was to investigate the effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes (M 1 to M 5) and estrogen receptor α, in the rat hippocampus. Hippocampi were obtained from rats in proestrus, rats ovariectomized for 15 da...
  2. Locally produced relaxin may affect testis and vas deferens function in rats.

    Reproduction 139(1):185 (2010) PMID 19812235

    We have previously shown that the rat testis and vas deferens contain high levels of the relaxin receptor, RXFP1. The present study was undertaken to determine the expression of relaxin in these tissues, and the effect of exogenous relaxin on Sertoli cell proliferation and on the mRNA levels of some...
  3. Effects of the antiestrogen fulvestrant (ICI 182,780) on gene expression of the rat efferent ductules.

    Biology of Reproduction 79(3):432 (2008) PMID 18495684

    We investigated the effects of ICI 182,780 treatment on gene expression using a microarray approach. Treatment with ICI 182,780 increased or reduced at least 2-fold the expression of 263 and 98 genes, respectively. Not surprisingly, several genes that encode ion channels and macromolecule transporte...
  4. Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus

    Life Sciences 86(21):832 (2010) PMID 20394757

    Aims The aim of the present study was to investigate the effects of different periods of ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of members of the Bcl-2 family in the rat hippocampus.
  5. Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinestera...

    Biochemical Pharmacology 75(9):1827 (2008) PMID 18329631

    The aim of the present study was to investigate the effects of estrogen lack and estrogen replacement on the production of total [ 3H]inositol phosphate ([ 3H]IP) induced by the activation of muscarinic acetylcholine receptors (mAChRs) and on the mechanisms for inactivation of acety...
  6. Effects of rat sinoaortic denervation on the vagal responsiveness and expression of muscarinic acetylcholine receptors.

    Journal of Cardiovascular Pharmacology 47(3):331 (2006) PMID 16633073

    We studied heart rate (HR) responses to vagal electrical stimulation (VES) and the expression of muscarinic acetylcholine receptors (mAChRs) in the rat atria 1 day (SADa) and 20 days (SADc) after sinoaortic denervation (SAD). Arterial blood pressure (BP) was recorded in conscious, unrestrained rats...
  7. Intracellular signaling pathways involved in the relaxin-induced proliferation of rat Sertoli cells

    European Journal of Pharmacology 691(1-3):283 (2012) PMID 22819701

    We have previously shown that relaxin and its G-protein coupled receptor RXFP1 are expressed in rat Sertoli cells, and that relaxin stimulates Sertoli cell proliferation. This study examined the mechanisms underlying the mitogenic effect of relaxin in a primary culture of Sertoli cells removed from...
  8. In vivo treatments with fulvestrant and anastrozole differentially affect gene expression in the rat efferent ductules.

    Biology of Reproduction 84(1):52 (2011) PMID 20826728

    We previously demonstrated that the antiestrogen fulvestrant markedly affected gene expression in the rat efferent ductules. The mechanism of fulvestrant action to modulate gene expression may involve not only the blockade of ESR1 and ESR2 estrogen receptors, but also the activation of ESR1 and ESR2...
  9. Ovariectomy and 17β-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-bin...

    Molecular and Cellular Endocrinology 382(1):227 (2014) PMID 24121025

    • Ovariectomy decreases the expression of endo-G in rat hippocampus. • Ovariectomy also decreases the phosphorylation of CREB....
  10. Estrogen receptors and function in the male reproductive system.

    Arquivos Brasileiros de Endocrinologia & Metabo... 53(8):923 (2009) PMID 20126844

    We focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system....