1. Ovariectomy and 17β-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus.

    Molecular and Cellular Endocrinology 382(1):227 (2014) PMID 24121025

    The aim of the present study was to investigate the effects of different periods of ovariectomy and 17β-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing factor (AIF) and Endonuclease-G (Endo-G) in mitochondrial and cytosolic fractions obtained from hippocampus of ...
  2. Intracellular signaling pathways involved in the relaxin-induced proliferation of rat Sertoli cells.

    European Journal of Pharmacology 691(1-3):283 (2012) PMID 22819701

    Regulation of Sertoli cell number is a key event to determine normal spermatogenesis. We have previously shown that relaxin and its G-protein coupled receptor RXFP1 are expressed in rat Sertoli cells, and that relaxin stimulates Sertoli cell proliferation. This study examined the mechanisms unde...
  3. In vivo treatments with fulvestrant and anastrozole differentially affect gene expression in the rat efferent ductules.

    Biology of Reproduction 84(1):52 (2011) PMID 20826728

    Estrogen plays a key role in maintaining the morphology and function of the efferent ductules. We previously demonstrated that the antiestrogen fulvestrant markedly affected gene expression in the rat efferent ductules. The mechanism of fulvestrant action to modulate gene expression may involve ...
  4. Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus

    Life Sciences 86(21):832 (2010) PMID 20394757

    Aims The aim of the present study was to investigate the effects of different periods of ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of members of the Bcl-2 family in the rat hippocampus.
  5. Effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes and estrogen receptor α in rat hippocampus

    European Journal of Pharmacology 634(1):192 (2010) PMID 20193677

    The aim of the present study was to investigate the effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes (M 1 to M 5) and estrogen receptor α, in the rat hippocampus. Hippocampi were obtained from rats in proestrus, rats ovariectomized for 15 ...
  6. Locally produced relaxin may affect testis and vas deferens function in rats.

    Reproduction 139(1):185 (2010) PMID 19812235

    We have previously shown that the rat testis and vas deferens contain high levels of the relaxin receptor, RXFP1. The present study was undertaken to determine the expression of relaxin in these tissues, and the effect of exogenous relaxin on Sertoli cell proliferation and on the mRNA levels of ...
  7. Effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes and estrogen receptor α in rat hippocampus

    European Journal of Pharmacology 634(1):192 (2010) PMID 20193677

    The aim of the present study was to investigate the effects of 17β-estradiol on expression of muscarinic acetylcholine receptor subtypes (M 1 to M 5) and estrogen receptor α, in the rat hippocampus. Hippocampi were obtained from rats in proestrus, rats ovariectomized for 15 ...
  8. Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus

    Life Sciences 86(21):832 (2010) PMID 20394757

    Aims The aim of the present study was to investigate the effects of different periods of ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of members of the Bcl-2 family in the rat hippocampus.
  9. Estrogen receptors and function in the male reproductive system.

    Arquivos brasileiros de endocrinologia e metabo... 53(8):923 (2009) PMID 20126844

    A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERalpha and ERbeta, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the...
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  10. Effects of the antiestrogen fulvestrant (ICI 182,780) on gene expression of the rat efferent ductules.

    Biology of Reproduction 79(3):432 (2008) PMID 18495684

    The efferent ductules express the highest amount of estrogen receptors ESR1 (ERalpha) and ESR2 (ERbeta) within the male reproductive tract. Treatment of rats with the antiestrogen fulvestrant (ICI 182,780) causes inhibition of fluid reabsorption in the efferent ductules, leading to seminiferous ...
  11. Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus.

    Biochemical Pharmacology 75(9):1827 (2008) PMID 18329631

    The aim of the present study was to investigate the effects of estrogen lack and estrogen replacement on the production of total [3H]inositol phosphate ([3H]IP) induced by the activation of muscarinic acetylcholine receptors (mAChRs) and on the mechanisms for inactivation of acetylcholine. Hippo...
  12. Effects of rat sinoaortic denervation on the vagal responsiveness and expression of muscarinic acetylcholine receptors.

    Journal of Cardiovascular Pharmacology 47(3):331 (2006) PMID 16633073

    We studied heart rate (HR) responses to vagal electrical stimulation (VES) and the expression of muscarinic acetylcholine receptors (mAChRs) in the rat atria 1 day (SADa) and 20 days (SADc) after sinoaortic denervation (SAD). Arterial blood pressure (BP) was recorded in conscious, unrestrained r...