1. The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis.

    Thrombosis Research 135(3):537 (2015) PMID 25586194

    Streptococcus (S.) pneumoniae is the most common causative pathogen in community-acquired pneumonia and sepsis. Activated protein C (APC) has been implicated as an important anticoagulant and anti-inflammatory mediator. We here sought to determine the role of the anticoagulant and cytoprotective...
  2. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.

    American Journal of Physiology - Heart and Circ... 308(2):H83 (2015) PMID 25380813 PMCID PMC4338937

    Sepsis is a life-threatening clinical condition that is particularly serious among the elderly who experience considerably higher mortality rates compared with younger patients. Using a sterile endotoxemia model, we previously reported age-dependent mortality in conjunction with enhanced coagula...
  3. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.

    American Journal of Physiology - Heart and Circ... 308(2):H83 (2015) PMID 25380813

    Sepsis is a life-threatening clinical condition that is particularly serious among the elderly who experience considerably higher mortality rates compared with younger patients. Using a sterile endotoxemia model, we previously reported age-dependent mortality in conjunction with enhanced coagula...
  4. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.

    American Journal of Physiology - Heart and Circ... 308(2):H83 (2015) PMID 25380813

    Sepsis is a life-threatening clinical condition that is particularly serious among the elderly who experience considerably higher mortality rates compared with younger patients. Using a sterile endotoxemia model, we previously reported age-dependent mortality in conjunction with enhanced coagula...
  5. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.

    American Journal of Physiology - Heart and Circ... 308(2):H83 (2015) PMID 25380813

    Sepsis is a life-threatening clinical condition that is particularly serious among the elderly who experience considerably higher mortality rates compared with younger patients. Using a sterile endotoxemia model, we previously reported age-dependent mortality in conjunction with enhanced coagula...
  6. Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.

    Blood 124(19):3031 (2014) PMID 25377566

  7. Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.

    Blood 124(19):3031 (2014) PMID 25377566

  8. Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.

    Blood 124(19):3031 (2014) PMID 25377566

  9. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.

    Circulation 130(14):1192 (2014) PMID 25266860

  10. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.

    Circulation 130(14):1192 (2014) PMID 25266860

  11. Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.

    Blood 124(10):1553 (2014) PMID 25049281 PMCID PMC4155268

    Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C anticoagulant pathway by promoting protein C activation. In the last decade, EPCR has received wide attention after i...
  12. Roles of Coagulation and fibrinolysis in angiotensin II-enhanced microvascular thrombosis.

    Microcirculation 21(5):401 (2014) PMID 24495184 PMCID PMC4107144

    AngII-induced HTN is associated with accelerated thrombus development in arterioles. This study assessed the contributions of different components of the coagulation cascade and fibrinolysis to AngII-mediated microvascular thrombosis. Light/dye-induced thrombus formation (the time of onset and f...
  13. The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis.

    Thrombosis and Haemostasis 111(5):970 (2014) PMID 24401906

    Pneumococcal pneumonia is a frequent cause of gram-positive sepsis and has a high mortality. The endothelial protein C receptor (EPCR) has been implicated in both the activation of protein C (PC) and the anti-inflammatory actions of activated (A)PC. The aim of this study was to determine the rol...
  14. Targeting factor Xa and thrombin: impact on coagulation and beyond.

    Thrombosis and Haemostasis 111(4):625 (2014) PMID 24336942

    Great advances have been made in recent years in understanding the haemostatic system and the molecular and cellular basis of thrombus formation. Although directly targeting factor Xa or thrombin (factor IIa) for effective anticoagulation is now well established, evidence has emerged suggesting ...
  15. Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo.

    Journal of Pharmacology and Experimental Therap... 347(2):339 (2013) PMID 23965383 PMCID PMC3807068

    Thrombomodulin (TM) is a glycoprotein normally present in the membrane of endothelial cells that binds thrombin and changes its substrate specificity to produce activated protein C (APC) that has antithrombotic and anti-inflammatory features. To compensate for loss of endogenous TM in pathology,...
  16. Protein C and acute inflammation: a clinical and biological perspective.

    American Journal of Physiology - Lung Cellular ... 305(7):L455 (2013) PMID 23911436

    The protein C system plays an active role in modulating severe systemic inflammatory processes such as sepsis, trauma, and acute respiratory distress syndrome (ARDS) via its anticoagulant and anti-inflammatory properties. Plasma levels of activated protein C (aPC) are lower than normal in acute ...
  17. Inhibition of endogenous activated protein C attenuates experimental autoimmune encephalomyelitis by inducing myeloid-derived suppressor cells.

    Journal of Immunology 191(7):3764 (2013) PMID 23997223 PMCID PMC3800123

    Activated protein C (PC) is an anticoagulant involved in the interactions between the coagulation and immune systems. Activated PC has broad anti-inflammatory effects that are mediated through its ability to modulate leukocyte function and confer vascular barrier protection. We investigated the ...
  18. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.

    Journal of Immunology 191(5):2665 (2013) PMID 23904166 PMCID PMC3777242

    Cellular processes that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not completely understood. Activation of the inflammasome plays a key role in response to invading intracellular pathogens, but mounting evidence suggests that it also plays a role in in...
  19. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation.

    Critical Care Medicine 41(9):2069 (2013) PMID 23979365

    To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation. Phase 2b, international, multicenter, double-blind, randomized, placebo-controlled, parallel group, screening trial. Two hundred and t...
  20. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.

    Journal of Immunology 191(5):2665 (2013) PMID 23904166 PMCID PMC3777242

    Cellular processes that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not completely understood. Activation of the inflammasome plays a key role in response to invading intracellular pathogens, but mounting evidence suggests that it also plays a role in in...