Increased incidence but improved median overall survival for biliary tract cancers diagnosed in Ontario from 1994 through 2012: A population-based study.
Cancer 122(16):2534 (2016)
To the authors' knowledge, the incidence of biliary tract cancer (BTC) in Canada is unknown. In the current study, the authors sought to describe the epidemiology of BTC using a large population-based cancer database from Ontario, Canada.
The current study was a population-based cohort study usi...
Patterns of Referral for Adjuvant Chemotherapy for Stage II and III Colon Cancer: A Population-Based Study.
Annals of Surgical Oncology 23(8):2529 (2016)
Reasons for variable utilization of adjuvant chemotherapy (ACT) for colon cancer have not been well described. We report medical oncology (MO) referral patterns and subsequent use of ACT.
Treatment records were linked to the population-based Ontario Cancer Registry to describe MO referral and AC...
Guideline on Muscle-Invasive and Metastatic Bladder Cancer (European Association of Urology Guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement.
Journal of Clinical Oncology 34(16):1945 (2016)
To endorse the European Association of Urology guideline on muscle-invasive (MIBC) and metastatic bladder cancer. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organiza...
Effects of a Structured Exercise Program on Physical Activity and Fitness in Colon Cancer Survivors: One Year Feasibility Results from the CHALLENGE Trial.
Cancer Epidemiology Biomarkers & Prevention 25(6):969 (2016)
There is strong interest in testing lifestyle interventions to improve cancer outcomes; however, the optimal methods for achieving behavior change in large-scale pragmatic trials are unknown. Here, we report the 1-year feasibility results for exercise behavior change in the Canadian Cancer Trial...
Prognostic and predictive effects of diabetes, hypertension, and coronary artery disease among women on extended adjuvant letrozole: NCIC CTG MA.17.
European Journal of Cancer 58:97 (2016)
Women with breast cancer and diabetes mellitus (DM) have poorer survival. Mechanisms include insulin dysregulation and/or DM related co-morbidities (CM). In MA.17 adjuvant letrozole (LET) after 5 years of tamoxifen (TAM) reduced the risk of recurrence and improved survival. We evaluated DM, hype...
Outcomes of Resected Colorectal Cancer Lung Metastases in Routine Clinical Practice: A Population-Based Study.
Annals of Surgical Oncology 23(4):1057 (2016)
Previous reports on the outcome of surgery for colorectal cancer lung metastases (CRCLM) have come from high-volume centers. This report describes the outcomes achieved in the general population of Ontario.
All patients in Ontario who underwent resection of CRCLM between 1994 and 2009 were ident...
Use of Palliative Chemotherapy for Advanced Bladder Cancer: Patterns of Care in Routine Clinical Practice.
Journal of the National Comprehensive Cancer Ne... 14(3):291 (2016)
Palliative chemotherapy for advanced bladder cancer is recommended in clinical practice guidelines. Patterns of care in routine clinical practice have not been well described. This article describes use rates of chemotherapy and referral rates to medical oncology in the last year of life among p...
Utilisation of preoperative imaging for muscle-invasive bladder cancer: a population-based study.
BJU International 117(3):430 (2016)
To test the hypotheses that: (i) use of preoperative imaging for muscle-invasive bladder cancer (MIBC) conforms to practice guidelines; (ii) preoperative imaging, through more accurate staging is associated with improved outcomes.
In this population-based cohort study, records of treatment were ...
Use and Effectiveness of Adjuvant Chemotherapy for Stage III Colon Cancer: A Population-Based Study.
Journal of the National Comprehensive Cancer Ne... 14(1):47 (2016)
International guidelines recommend adjuvant chemotherapy (ACT) for patients with stage III colon cancer. Whether efficacy observed in clinical trials translates to effectiveness in routine practice is less well understood. Here we describe use and outcomes of ACT in routine practice.
All cases o...
Perioperative chemotherapy for muscle-invasive bladder cancer: Closing the gap between evidence and practice.
Canadian Urological Association Journal 10(1-2):31 (2016)
Temsirolimus Maintenance Therapy After Docetaxel Induction in Castration-Resistant Prostate Cancer.
Oncologist 20(12):1351 (2015)
Temsirolimus maintenance therapy after docetaxel induction chemotherapyis safe in patients with castration-resistant prostate cancer, although biochemical or tumor responses are rare;does not diminish quality of life; anddelays radiological and/or symptomatic progression by approximately 6 month...
Use of Preoperative Magnetic Resonance Imaging for Breast Cancer: A Canadian Population-Based Study.
JAMA Oncology 1(9):1238 (2015)
Contrary to practice guidelines, breast magnetic resonance imaging (MRI) is commonly used in the preoperative evaluation of women with breast cancer. While existing literature has found little benefit to MRI in most patients, potential downstream consequences associated with breast MRI are not w...
Management and Outcome of Colorectal Cancer Liver Metastases in Elderly Patients: A Population-Based Study.
JAMA Oncology 1(8):1111 (2015)
Surgical resection is standard treatment for patients with colorectal cancer (CRC) liver metastases (LM). Limited data describe practice and outcomes among elderly patients.
To describe management and outcomes of surgical resection of CRC LM in elderly patients in routine practice.
Lymph node counts are valid indicators of the quality of surgical care in bladder cancer: a population-based study.
Urologic Oncology: Seminars and Original Invest... 33(10):425.e15 (2015)
To describe lymph node counts in routine clinical practice and evaluate their association with outcomes to explore its utility as a quality indicator.
Electronic records of treatment and surgical pathology reports were linked with the population-based Ontario Cancer Registry to identify all pati...
Outcomes of squamous histology in bladder cancer: a population-based study.
Urologic Oncology: Seminars and Original Invest... 33(10):425.e7 (2015)
Squamous cell carcinoma (SCC) of the bladder is an uncommon form of bladder cancer. Using a large population-based sample we sought to describe the outcomes of patients with squamous histology and to define the factors that influence prognosis in these patients.
All incident cases of bladder can...
Imaging for distant metastases in women with early-stage breast cancer: a population-based cohort study.
Canadian Medical Association Journal 187(12):E387 (2015)
Practice guidelines recommend that imaging to detect metastatic disease not be performed in the majority of patients with early-stage breast cancer who are asymptomatic. We aimed to determine whether practice patterns in Ontario conform with these recommendations.
We used provincial registry dat...
Benefits of Adjuvant Chemotherapy for Bladder Cancer.
JAMA Oncology 1(6):727 (2015)
Pathological factors associated with survival benefit from adjuvant chemotherapy (ACT): a population-based study of bladder cancer.
BJU International 116(3):373 (2015)
To evaluate whether pathological factors are associated with differential effect of adjuvant chemotherapy (ACT).
In this population-based retrospective cohort study, we linked electronic records of treatment and surgical pathology to the Ontario Cancer Registry. The study population included all...
Radical cystectomy and adjuvant chemotherapy for bladder cancer in the elderly: a population-based study.
Urology 85(4):791 (2015)
To assess radical cystectomy (RC) outcomes and adjuvant chemotherapy (ACT) use in the elderly in routine practice. Bladder cancer occurs most commonly in the elderly. RC, standard treatment for muscle-invasive bladder cancer, presents challenges in older patients. Suboptimal evidence guides ACT ...
A phase II study of GW786034 (pazopanib) with or without bicalutamide in patients with castration-resistant prostate cancer.
Clinical Genitourinary Cancer 13(2):124 (2015)
Pazopanib is an oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor. In this randomized, open label phase II study, pazopanib alone or in combination with bicalutamide was evaluated in patients with chemotherapy-naive castration-resistant prostate cancer (CRPC).