1. Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.

    Neuroscience Letters 600:220 (2015) PMID 26101828

    Parkinson's disease (PD) is a common movement disorder in the elderly. In the present study, we examined whether the combination of hyperbaric oxygen (HBO) and madopar therapy provided a neuroprotective effect on dopaminergic neurons in the substantia nigra using a rat model of PD. Rotational as...
  2. Yulangsan polysaccharide improves redox homeostasis and immune impairment in D-galactose-induced mimetic aging.

    Food & Function 6(5):1712 (2015) PMID 25920068

    Yulangsan polysaccharide (YLSP) is a traditional Chinese medicine used in long-term treatment as a modulator of brain dysfunction and immunity. In this study, we evaluated the protective effect of YLSP against D-galactose-induced impairment of oxidative stress and the immune system and evaluated...
  3. Outcomes of microwave ablation for colorectal cancer liver metastases: A single center experience.

    Journal of Surgical Oncology 111(4):410 (2015) PMID 25557924

    Surgical management of colorectal cancer liver metastases continues to evolve to optimize oncologic outcomes while maximizing parenchymal preservation. Long-term data after intraoperative microwave ablation are limited. This study investigates outcomes and patterns of recurrence in patients who ...
  4. Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience.

    Journal of Surgical Oncology 111(4):410 (2015) PMID 25557924 PMCID PMC4499323

    Surgical management of colorectal cancer liver metastases continues to evolve to optimize oncologic outcomes while maximizing parenchymal preservation. Long-term data after intraoperative microwave ablation are limited. This study investigates outcomes and patterns of recurrence in patients who ...
  5. Palladium(II)-Catalyzed Sequential C-H Arylation/Aerobic Oxidative C-H Amination: One-Pot Synthesis of Benzimidazole-Fused Phenanthridines from 2-Arylbenzimidazoles and Aryl Halides.

    Journal of Organic Chemistry 80(5):2827 (2015) PMID 25658883

    Starting from 2-arylbenzimidazoles and aryl halides, an efficient palladium-based catalytic method for the synthesis of benzimidazole-fused phenanthridines has been developed. This reaction sequence comprises intermolecular C-H arylation and intramolecular aerobic oxidative C-H amination, involv...
  6. Protective immunity against Schistosoma japonicum infection can be provided by IgG antibodies towards periodate-sensitive or periodate-resistant glycans.

    Parasites & Vectors 8(1):234 (2015) PMID 25907161 PMCID PMC4408597

    It has been well accepted that glycans present in schistosomes are highly antigenic. However, it is not clear what kind of worm glycans can affect the infected host to mount IgG responses and whether mounted anti-glycan IgG responses are protective. The contribution of antigenicity by glycans wa...
  7. Multiplex fluorescence quantitative polymerase chain reaction for simultaneous detection of hepatitis B virus, hepatitis C virus and human immunodeficiency virus.

    Clinical laboratory 61(1-2):53 (2015) PMID 25807638

    To construct a multiplex fluorescence quantitative polymerase chain reaction (MFQ-PCR) system to simultaneously detect hepatitis B virus (HBV) DNA, hepatitis C virus (HCV) cDNA, and human immunodeficiency virus (HIV) cDNA to reduce the false positive and false negative results, therefore increas...
  8. Association between the European GWAS-identified susceptibility locus at chromosome 4p16 and the risk of atrial septal defect: a case-control study in Southwest China and a meta-analysis.

    PLoS ONE 10(4):e0123959 (2015) PMID 25875170 PMCID PMC4395394

    Atrial septal defect (ASD) is the third most frequent type of congenital heart anomaly, featuring shunting of blood between the two atria. Gene-environment interaction remains to be an acknowledged cause for ASD occurrence. A recent European genome-wide association study (GWAS) of congenital hea...
  9. DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.

    Nucleic Acids Research 43(2):1268 (2015) PMID 25567984

    FOXP3 is a lineage-specific transcription factor that is required for regulatory T cell development and function. In this study, we determined the crystal structure of the FOXP3 forkhead domain bound to DNA. The structure reveals that FOXP3 can form a stable domain-swapped dimer to bridge DNA in...
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  10. DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.

    Nucleic Acids Research 43(2):1268 (2015) PMID 25567984 PMCID PMC4333414

    FOXP3 is a lineage-specific transcription factor that is required for regulatory T cell development and function. In this study, we determined the crystal structure of the FOXP3 forkhead domain bound to DNA. The structure reveals that FOXP3 can form a stable domain-swapped dimer to bridge DNA in...
  11. Does nodule size predict compressive symptoms in patients with thyroid nodules?

    Gland surgery 3(4):232 (2014) PMID 25493254 PMCID PMC4244507

    Thyromegaly and thyroid nodules are known to cause compressive symptoms, but the exact relationship between nodule size and development of compressive symptoms is unclear. We sought to determine whether compressive symptoms are directly related to nodule size. A retrospective analysis of 99 pati...
  12. Does nodule size predict compressive symptoms in patients with thyroid nodules?

    Gland surgery 3(4):232 (2014) PMID 25493254 PMCID PMC4244507

    Thyromegaly and thyroid nodules are known to cause compressive symptoms, but the exact relationship between nodule size and development of compressive symptoms is unclear. We sought to determine whether compressive symptoms are directly related to nodule size. A retrospective analysis of 99 pati...
  13. Does nodule size predict compressive symptoms in patients with thyroid nodules?

    Gland surgery 3(4):232 (2014) PMID 25493254

    Thyromegaly and thyroid nodules are known to cause compressive symptoms, but the exact relationship between nodule size and development of compressive symptoms is unclear. We sought to determine whether compressive symptoms are directly related to nodule size. A retrospective analysis of 99 pati...
  14. Is preoperative fibrinogen really not associated with blood transfusion?

    Annals of Thoracic Surgery 98(3):1142 (2014) PMID 25193217

  15. Is Preoperative Fibrinogen Really Not Associated With Blood Transfusion?

    Annals of Thoracic Surgery 98(3):1142 (2014) PMID 25193217

  16. Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology.

    Journal of Surgical Research 190(2):565 (2014) PMID 24880201

    Thyroid nodules are present in 19%-67% of the population and carry a 5%-10% risk of malignancy. Unfortunately, fine-needle aspiration biopsies are indeterminate in 20%-30% of patients, often necessitating thyroid surgery for diagnosis. Numerous DNA microarray studies including a recently commerc...
  17. Yulangsan polysaccharide attenuates withdrawal symptoms and regulates the NO pathway in morphine-dependent rats.

    Neuroscience Letters 570:63 (2014) PMID 24747687

    Yulangsan polysaccharide (YLSP) has been utilized as a phytomedicine to managing nervous dysfunction in China. Thus, this study aimed to evaluate the potential YLSP-mediated detoxification role against morphine dependence in rats. The results indicated that the morphine dependence model signific...
  18. Association between the ABO blood group and risk of common cancers.

    Journal Of Evidence Based Medicine 7(2):79 (2014) PMID 25155765

    To investigate the association between five common cancers in western China population and ABO blood group. Using the data from West China Hospital, we retrospectively reviewed 5012 patients with five common cancers. Blood groups were obtained from medical records. The control group was represen...
  19. Association between the ABO blood group and risk of common cancers.

    Journal Of Evidence Based Medicine 7(2):79 (2014) PMID 25155765

    To investigate the association between five common cancers in western China population and ABO blood group. Using the data from West China Hospital, we retrospectively reviewed 5012 patients with five common cancers. Blood groups were obtained from medical records. The control group was represen...
  20. Modular synthesis of benzimidazole-fused phenanthridines from 2-arylbenzimidazoles and o-dibromoarenes by a palladium-catalyzed cascade process.

    Organic Letters 16(7):1872 (2014) PMID 24641253

    An efficient palladium-catalyzed route for the synthesis of benzimidazole-fused phenanthridines from o-dibromoarenes and 2-arylbenzimidazoles is described. The sequentially accomplished reaction comprises intermolecular C-H arylation of 2-arylbenzimidazoles followed by an intramolecular N-arylat...