1. History and Current Status of Cardiovascular Surgery at the University of Pennsylvania.

    Seminars in Thoracic and Cardiovascular Surgery 27(4):370 (2015) PMID 26811043

    The cardiothoracic surgery program at the University of Pennsylvania has enjoyed a decades long tradition of leadership and contributions to the field. Consistent with its place as a robust contributor in a major academic medical center, its focus is on the tripartite mission of clinical care, r...
  2. Improvement in ╬▓-cell secretory capacity after human islet transplantation according to the CIT07 protocol.

    Diabetes 62(8):2890 (2013) PMID 23630300 PMCID PMC3717864

    The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as in the Edmonton protocol. To determine whethe...
  3. Historical overview of transplantation.

    Cold Spring Harbor perspectives in medicine 3(4):a014977 (2013) PMID 23545575 PMCID PMC3684003

    Except for legends and claims of miracles, most histories of transplantation cover only the last 60 years because there were no earlier successes. However, the story of even this era has been documented in such rich detail that a full account would fill several volumes. Thus, this brief summary ...
  4. Making imaging research a part of radiology resident training.

    Academic Radiology 20(2):135 (2013) PMID 23395241

  5. Islet alone versus islet after kidney transplantation: metabolic outcomes and islet graft survival.

    Transplantation 88(6):820 (2009) PMID 19920782 PMCID PMC2805912

    Isolated islet transplantation with infusions from two to three donor pancreata and Edmonton immunosuppression consistently achieves insulin independence in patients with type 1 diabetes. The success of this protocol has been attributed to a novel combination of immunosuppressive agents and avoi...
  6. Thomas Eakins and his medical clinics.

    Proceedings of the American Philosophical Society 153(1):1 (2009) PMID 19848107

  7. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

    Nature Medicine 13(11):1295 (2007) PMID 17965721

    We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
  8. Availability of suitable islet donors in the United States.

    Transplantation 84(2):280 (2007) PMID 17667824

    We characterize donor utilization for islet transplantation and estimate the number of recipients who could achieve normoglycemia through islet transplantation if the current donor pool were used. Potential islet donors from all United Network for Organ Sharing donors (1/00-5/04) were identified...
  9. T-reg mediated suppression of the allograft response in the draining lymph node.

    Transplantation 81(7):1063 (2006) PMID 16612285

    We previously demonstrated that T-regs inhibit proliferation of graft-reactive T cells in the draining lymph node (DLN), suggesting that this site may be important for regulation. TCR transgenic mice (TS1) specific for viral hemagglutinin (HA) provided antigen-specific T cells for adoptive trans...
  10. Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes.

    Diabetes 54(11):3205 (2005) PMID 16249446

    Islet transplantation can eliminate severe hypoglycemic episodes in patients with type 1 diabetes; however, whether intrahepatic islets respond appropriately to hypoglycemia after transplantation has not been fully studied. We evaluated six islet transplant recipients, six type 1 diabetic subjec...
  11. Comparison of whole organ pancreas and isolated islet transplantation for type 1 diabetes.

    Advances in Surgery 39:137 (2005) PMID 16250550

  12. {beta}-Cell function following human islet transplantation for type 1 diabetes.

    Diabetes 54(1):100 (2005) PMID 15616016

    Islet transplantation can provide metabolic stability for patients with type 1 diabetes; however, more than one donor pancreas is usually required to achieve insulin independence. To evaluate possible mechanistic defects underlying impaired graft function, we studied five subjects at 3 months an...
  13. Transplantation for type I diabetes: comparison of vascularized whole-organ pancreas with isolated pancreatic islets.

    Annals of Surgery 240(4):631 (2004) PMID 15383791 PMCID PMC1356465

    We sought to compare the efficacy, risks, and costs of whole-organ pancreas transplantation (WOP) with the costs of isolated islet transplantation (IIT) in the treatment of patients with type I diabetes mellitus. A striking improvement has taken place in the results of IIT with regard to attaini...
  14. Decreased use of iliac extensions and reduced graft junctions with software-assisted centerline measurements in selection of endograft components for endovascular aneurysm repair.

    Journal of Vascular Surgery 40(2):222 (2004) PMID 15297814

    The purpose of this study was to determine the impact of using computerized software-assisted centerline measurements for extensions and graft junctions during the selection of endograft components for modular aortic endografts in endovascular repair of abdominal aortic aneurysms. From April 199...
  15. Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation.

    Journal of Immunology 172(11):6539 (2004) PMID 15153467

    Regulatory T cells preserve tolerance to peripheral self-Ags and may control the response to allogeneic tissues to promote transplantation tolerance. Although prior studies have demonstrated prolonged allograft survival in the presence of regulatory T cells (T-reg), data documenting the capacity...
  16. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.

    Diabetes 53(3):624 (2004) PMID 14988246

    Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic islet cells. Whether the latter represents a primary defect or is a consequence of the former is unknown. To examine the beta-cell mass and function of islets from type 2 diabetic patients dire...
  17. Invited commentary

    Journal of the American College of Surgeons 198(4):568 (2004)

  18. Is surgical science dead? The Excelsior Society lecture.

    Journal of the American College of Surgeons 198(1):1 (2004) PMID 14698306

  19. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?

    Transplantation 76(11):1623 (2003) PMID 14702535

    The recent success of islet transplantation using the Edmonton protocol involved the use of sirolimus, tacrolimus, and daclizumab for immunosuppression. Islets were infused into the portal circulation after transhepatic access. This protocol provided a unique opportunity to measure sirolimus and...
  20. Geographic differences in access to transplantation in the United States.

    Transplantation 76(9):1389 (2003) PMID 14627922

    The Etablissement fran├žais des Greffes reports regional variability in access to organ transplantation in France. Some variability seems to be inevitable for reasons discussed in the French article. We provide comparative data on a similar phenomenon in the United States, including some historic...