Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis.
Journal of Hepatology 65(3):589 (2016)
There have been many studies of the effects of non-alcoholic fatty liver disease (NAFLD) and the risk of cardiovascular disease (CVD), but these have produced conflicting results. We performed a meta-analysis of these studies to quantify the magnitude of the association between NAFLD (and NAFLD ...
First-generation antipsychotics and QTc: any role for mediating variables?
Human Psychopharmacology: Clinical and Experime... 31(4):313 (2016)
Corrected QT (QTc) interval prolongation is often associated with use of first-generation antipsychotics (FGAs). However, other factors require appropriate consideration, including age and gender, the role of other known medications associated with QTc prolongation, and severe comorbid condition...
Efficacy and safety of anti-epileptic drugs in patients with active convulsive seizures when no IV access is available: Systematic review and meta-analysis.
Epilepsy Research 122:47 (2016)
To explore the existing evidence for anti-convulsant drugs and their routes of administration in treating acute seizures in children and adults when intravenous access is not available.
All major databases including Medline via Ovid, PubMed, Cochrane CENTRAL, Embase, and Google Scholar were sear...
Efficacy of selective serotonin reuptake inhibitors and adverse events: meta-regression and mediation analysis of placebo-controlled trials.
British Journal of Psychiatry 208(2):114 (2016)
It has been suggested that the efficacy of antidepressants has been overestimated in clinical trials owing to unblinding of drug treatments by adverse events.
To investigate the association between adverse events and the efficacy of selective serotonin reuptake inhibitors (SSRIs).
Antipsychotic Dose Mediates the Association between Polypharmacy and Corrected QT Interval.
PLoS ONE 11(2):e0148212 (2016)
Antipsychotic (AP) drugs have the potential to cause prolongation of the QT interval corrected for heart rate (QTc). As this risk is dose-dependent, it may be associated with the number of AP drugs concurrently prescribed, which is known to be associated with increased cumulative equivalent AP d...
Stopping antidepressants following depression.
British Medical Journal (Abstracts) 352:i220 (2016)
Sharing all types of clinical data and harmonizing journal standards.
BMC Medicine 14(1):63 (2016)
Despite recent efforts to enforce policies requiring the sharing of data underlying clinical findings, current policies of biomedical journals remain largely heterogeneous. As this heterogeneity does not optimally serve the cause of data sharing, a first step towards better harmonization would b...
Using GRADE to update WHO recommendations for MNS.
The lancet psychiatry 2(12):1054 (2015)
Efficacy and acceptability of antidepressants on the continuum of depressive experiences in patients with cancer: Systematic review and meta-analysis.
Cancer Treatment Reviews 41(8):714 (2015)
Patients with cancer are particularly vulnerable to depressive experiences, ranging from severe emotional reactions to proper depressive syndromes, including major depression. These experiences may deeply affect the course and outcome of the disease. The aim of this study was to assess the effic...
British Journal of Psychiatry 207(2):177 (2015)
Antipsychotic drug exposure and risk of pneumonia: a systematic review and meta-analysis of observational studies.
Pharmacoepidemiology and Drug Safety 24(8):812 (2015)
Pneumonia is one of the major leading causes of morbidity and mortality among persons aged 65 years or older. Recently, several studies suggested an association between antipsychotic (AP) use and risk of pneumonia in elderly patients. The aim of the present systematic review and meta-analysis of...
Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials.
Journal of Affective Disorders 180:179 (2015)
Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have been applied to date. The purpose of the present stud...
Do Cochrane systematic reviews meet WHO needs?
British journal of addiction 110(6):899 (2015)
Closing forensic psychiatric hospitals in Italy: a new revolution begins?
British Journal of Psychiatry 206(6):445 (2015)
On 30 May 2014 the Italian Parliament approved a new law regarding forensic psychiatric hospitals. Forensic psychiatric hospitals are facilities that admit individuals who have committed a criminal offence but lack criminal responsibility because of a mental disorder and are deemed as dangerous ...
Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis.
The lancet psychiatry 2(5):413 (2015)
An increasing number of studies have investigated the pharmacological prevention of post-traumatic stress disorder (PTSD) and acute stress disorder (ASD). This is the first systematic review to examine the effects of pharmacotherapies (eg, β blockers, hydrocortisone, and selective serotonin re-u...
Rigour of development of clinical practice guidelines for the pharmacological treatment of bipolar disorder: systematic review.
Journal of Affective Disorders 174:45 (2015)
There is an increasing concern about the quality of clinical practice guidelines. Because no information is available on the rigour of development of clinical practice guidelines for bipolar disorder, we carried out a systematic review of those focusing on its pharmacological treatment.
Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis.
British Journal of Psychiatry 206(2):93 (2015)
Pharmacological treatment is widely used for post-traumatic stress disorder (PTSD) despite questions over its efficacy.
To determine the efficacy of all types of pharmacotherapy, as monotherapy, in reducing symptoms of PTSD, and to assess acceptability.
A systematic review and meta-analysis of r...
Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case-control study.
BMC Psychiatry 15:92 (2015)
Only three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to establish the risk of pulmonary embolism associated with antipsychotic drugs, and to asce...
Antidepressants for the treatment of depression in people with cancer.
Cochrane database of systematic reviews 6(6):CD011006 (2015)
Major depression and other depressive conditions are common in people with cancer. These conditions are not easily detectable in clinical practice, due to the overlap between medical and psychiatric symptoms, as described by diagnostic manuals such as the Diagnostic and Statistical Manual of Men...
When important steps for a reliable meta-analysis are missing: the bevacizumab versus ranibizumab case.
International journal of ophthalmology 8(1):204 (2015)