1. Toxicity evaluation of new agricultural fungicides in primary cultured cortical neurons.

    Environmental Research 140:37 (2015) PMID 25825129

    Fungicides are crucial for food protection as well as for the production of crops of suitable quality and quantity to provide a viable economic return. Like other pesticides, fungicides are widely sprayed on agricultural land, especially in wine-growing areas, from where they can move-off after ...
  2. Putative adverse outcome pathways relevant to neurotoxicity.

    Critical Reviews in Toxicology 45(1):83 (2015) PMID 25605028

    The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological...
  3. Putative adverse outcome pathways relevant to neurotoxicity.

    Critical Reviews in Toxicology 45(1):83 (2015) PMID 25605028

    The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological...
  4. IrOx-carbon nanotube hybrids: a nanostructured material for electrodes with increased charge capacity in neural systems.

    Acta Biomaterialia 10(10):4548 (2014) PMID 24952073

    Nanostructured iridium oxide-carbon nanotube hybrids (IrOx-CNT) deposited as thin films by dynamic electrochemical methods are suggested as novel materials for neural electrodes. Single-walled carbon nanotubes (SWCNT) serve as scaffolds for growing the oxide, yielding a tridimensional structure ...
  5. IrOx-carbon nanotube hybrids: a nanostructured material for electrodes with increased charge capacity in neural systems.

    Acta Biomaterialia 10(10):4548 (2014) PMID 24952073

    Nanostructured iridium oxide-carbon nanotube hybrids (IrOx-CNT) deposited as thin films by dynamic electrochemical methods are suggested as novel materials for neural electrodes. Single-walled carbon nanotubes (SWCNT) serve as scaffolds for growing the oxide, yielding a tridimensional structure ...
  6. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

    Neuropharmacology 81:55 (2014) PMID 24486380

    Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free ac...
  7. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

    Neuropharmacology 81:55 (2014) PMID 24486380

    Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free ac...
  8. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

    Neuropharmacology 81:55 (2014) PMID 24486380

    Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free ac...
  9. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

    Neuropharmacology 81:55 (2014)

    Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months ...
  10. Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate

    NeuroToxicology 40:102 (2014)

    • We have determined glutamate and aspartate levels on cord blood. • Glutamate levels were negatively associated with levels of PCB138, β-HCH and the sum of seven ...
  11. Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate

    NeuroToxicology 40:102 (2014)

    • We have determined glutamate and aspartate levels on cord blood. • Glutamate levels were negatively associated with levels of PCB138, β-HCH and the sum of seven ...
  12. Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate

    NeuroToxicology 40:102 (2014)

    • We have determined glutamate and aspartate levels on cord blood. • Glutamate levels were negatively associated with levels of PCB138, β-HCH and the sum of seven ...
  13. Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate

    NeuroToxicology 40:102 (2014) PMID 24361731

    • We have determined glutamate and aspartate levels on cord blood. • Glutamate levels were negatively associated with levels of PCB138, β-HCH and the sum of seven ...
  14. Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate.

    NeuroToxicology 40:102 (2014) PMID 24361731

    Some chemicals released into the environment, including mercury and some organochlorine compounds (OCs), are suspected to have a key role on subclinical brain dysfunction in childhood. Alteration of the glutamatergic system may be one mechanistic pathway. We aimed to determine whether mercury an...
  15. Allopregnanolone and pregnanolone analogues modified in the C ring: synthesis and activity.

    Journal of medicinal and pharmaceutical chemistry 56(6):2323 (2013) PMID 23421641

    (25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one),...
  16. Allopregnanolone and pregnanolone analogues modified in the C ring: synthesis and activity.

    Journal of medicinal and pharmaceutical chemistry 56(6):2323 (2013) PMID 23421641

    (25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one),...
  17. Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure.

    Toxicology Letters 216(2-3):73 (2013) PMID 23194828

    Pesticide exposure has been associated with neuropsychological and psychiatric impairments and neurodegenerative disorders. Pesticide exposure commonly causes a deficit in inhibitory control behaviours. In the present study, we investigated whether acute exposure to organophosphate (OP) chlorpyr...
  18. Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure.

    Toxicology Letters 216(2-3):73 (2013) PMID 23194828

    Pesticide exposure has been associated with neuropsychological and psychiatric impairments and neurodegenerative disorders. Pesticide exposure commonly causes a deficit in inhibitory control behaviours. In the present study, we investigated whether acute exposure to organophosphate (OP) chlorpyr...
  19. Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure

    Toxicology Letters 216(2-3):73 (2013)

    Highlights ► Acute CPF exposure induced long term perseveration on the 5-CSRT task. ► d-amphetamine reduced the increased perseveration in CPF-group on 5-CSRT task, showing a reduction also in correct trials. ► CPF group showed decreased levels of GABA and glutamate in the st...
  20. Strategies and tools for preventing neurotoxicity: to test, to predict and how to do it.

    NeuroToxicology 33(4):796 (2012) PMID 22342764

    A change in paradigm is needed in the prevention of toxic effects on the nervous system, moving from its present reliance solely on data from animal testing to a prediction model mostly based on in vitro toxicity testing and in silico modeling. According to the report published by the National R...