1. KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.

    Journal of Alzheimer's Disease 33(1):111 (2013) PMID 22914592 PMCID PMC3731451

    KIF6 719Arg allele carriers are thought to have a greater lipid lowering response from statin therapy than non-carriers. Given the continued interest in the relationship between cholesterol, statin use, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD), investigating the ro...
  2. KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.

    Journal of Alzheimer's Disease 33(1):111 (2013) PMID 22914592 PMCID PMC3731451

    KIF6 719Arg allele carriers are thought to have a greater lipid lowering response from statin therapy than non-carriers. Given the continued interest in the relationship between cholesterol, statin use, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD), investigating the ro...
  3. Statins to treat Alzheimer's disease: an incomplete story.

    Expert Review of Neurotherapeutics 12(1):27 (2012) PMID 22243043

    The link between cholesterol and Alzheimer's disease (AD) has been explored for almost two decades. The link stems from the observation that atherosclerotic heart disease increases the risk for AD and that people expiring from coronary artery disease had AD changes in their brains. Cholesterol i...
  4. Cholesterol increases ventricular volume in a rabbit model of Alzheimer's disease.

    Journal of Alzheimer's Disease 29(2):283 (2012) PMID 22232012 PMCID PMC3628552

    One of the hallmarks of Alzheimer's disease is a significant increase in ventricular volume. To date we and others have shown that a cholesterol-fed rabbit model of Alzheimer's disease displays as many as fourteen different pathological markers of Alzheimer's disease including amyloid-β accumula...
  5. Tau is reduced in AD plasma and validation of employed ELISA methods.

    American Journal of Neurodegenerative Disease 1(1):99 (2012) PMID 23383382 PMCID PMC3560452

    Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (MCI) and/or Alzheimer's disease (AD). Employing ELISA methods,...
  6. Statins to treat Alzheimer's disease: an incomplete story.

    Expert Review of Neurotherapeutics 12(1):27 (2012) PMID 22243043

    The link between cholesterol and Alzheimer's disease (AD) has been explored for almost two decades. The link stems from the observation that atherosclerotic heart disease increases the risk for AD and that people expiring from coronary artery disease had AD changes in their brains. Cholesterol i...
  7. Tau is reduced in AD plasma and validation of employed ELISA methods.

    American Journal of Neurodegenerative Disease 1(1):99 (2012) PMID 23383382 PMCID PMC3560452

    Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (MCI) and/or Alzheimer's disease (AD). Employing ELISA methods,...
  8. Cholesterol increases ventricular volume in a rabbit model of Alzheimer's disease.

    Journal of Alzheimer's Disease 29(2):283 (2012) PMID 22232012 PMCID PMC3628552

    One of the hallmarks of Alzheimer's disease is a significant increase in ventricular volume. To date we and others have shown that a cholesterol-fed rabbit model of Alzheimer's disease displays as many as fourteen different pathological markers of Alzheimer's disease including amyloid-β accumula...
  9. Alzheimer disease: statins in the treatment of Alzheimer disease.

    Nature Clinical Practice Neurology 7(12):662 (2011) PMID 22009281

  10. Alzheimer disease: statins in the treatment of Alzheimer disease.

    Nature Clinical Practice Neurology 7(12):662 (2011) PMID 22009281

  11. Copper status in Alzheimer's disease and other neurodegenerative disorders: genetics, mechanisms, neurophysiology, and therapies.

    International Journal of Alzheimer's Disease 2011:903940 (2011) PMID 22216415 PMCID PMC3246719

  12. Influence of water quality on cholesterol-induced tau pathology: preliminary data.

    International Journal of Alzheimer's Disease 2011:987023 (2011) PMID 21559186 PMCID PMC3089913

    The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of NFT. We measured brain and plasma tau levels and semiquantified NFT-like n...
  13. Copper status in Alzheimer's disease and other neurodegenerative disorders: genetics, mechanisms, neurophysiology, and therapies.

    International Journal of Alzheimer's Disease 2011:903940 (2011) PMID 22216415 PMCID PMC3246719

  14. Influence of water quality on cholesterol-induced tau pathology: preliminary data.

    International Journal of Alzheimer's Disease 2011:987023 (2011) PMID 21559186 PMCID PMC3089913

    The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of NFT. We measured brain and plasma tau levels and semiquantified NFT-like n...
  15. Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid beta-peptide accumulation.

    Journal of Magnetic Resonance Imaging 32(2):306 (2010) PMID 20677255 PMCID PMC3059766

    To test the hypothesis that narrowing of cranial blood vessels in cholesterol-fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk. Four groups of New Zealand Wh...
  16. Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid beta-peptide accumulation.

    Journal of Magnetic Resonance Imaging 32(2):306 (2010) PMID 20677255 PMCID PMC3059766

    To test the hypothesis that narrowing of cranial blood vessels in cholesterol-fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk. Four groups of New Zealand Wh...
  17. Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort.

    Neurodegenerative Diseases 7(1-3):183 (2010) PMID 20224282 PMCID PMC2859238

    We reported a significant 67% reduction in the hazard risk of incident Alzheimer's disease (AD) with elective statin use in the AD Anti-inflammatory Prevention Trial (ADAPT), without a reduction in risk of incident mild cognitive impairment (MCI). To assess if cholesterol levels are associated w...
  18. Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort.

    Neurodegenerative Diseases 7(1-3):183 (2010) PMID 20224282 PMCID PMC2859238

    We reported a significant 67% reduction in the hazard risk of incident Alzheimer's disease (AD) with elective statin use in the AD Anti-inflammatory Prevention Trial (ADAPT), without a reduction in risk of incident mild cognitive impairment (MCI). To assess if cholesterol levels are associated w...
  19. Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors.

    American Journal of Medical Genetics. Part B: N... 150B(2):290 (2009) PMID 18521860

    Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin-converting enzyme (ACE) gene insertion/dele...
  20. Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors.

    American Journal of Medical Genetics. Part B: N... 150B(2):290 (2009) PMID 18521860

    Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin-converting enzyme (ACE) gene insertion/dele...