1. Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.

    PNAS 106(46):19286 (2009) PMID 19880750 PMCID PMC2780808

    Profiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class of genes that rapidly coassemble p300 and RNA polymerase II (pol II) following mitogen stimulation. Several of these p300 targets are immediate early genes, including FOS, implicating a prominen...
  2. Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.

    Cell Cycle 8(13):2093 (2009) PMID 19502793 PMCID PMC2809250

    NFkappaB is an inducible transcription factor that controls kinetically complex patterns of gene expression. Several studies reveal multiple pathways linking NFkappaB to the promotion and progression of various cancers. Despite extensive interest and characterization, many NFkappaB controlled ge...
  3. Combination chemotherapy of disseminated kaposi's sarcoma in patients with the acquired immune deficiency syndrome

    The American Journal of Medicine 82(3):456 (1987)

    Two clinical trials were conducted to assess the efficacy and safety of a combination chemotherapy regimen for the treatment of Kaposi's sarcoma in patients with the acquired immune deficiency syndrome (AIDS). Eighteen consecutive patients with disseminated Kaposi's sarcoma were treated wit...
  4. Human lymphoblastoid interferon treatment of Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical response and prognostic parameters

    The American Journal of Medicine 78(5):737 (1985)

    Thirty consecutive patients with the acquired immune deficiency syndrome were treated with intramuscular human lymphoblastoid interferon for Kaposi's sarcoma. Patients were divided Into three groups receiving 7.5 million units/m 2 per day, 15 million units/m 2 per day, or 25 mil...
  5. New beta-lactam antibiotics in granulocytopenic patients: New options and new questions

    The American Journal of Medicine 79(2):75 (1985)

    Infectious complications are a frequent cause of morbidity and, at many centers, the major cause of death in patients with cancer. The increased risk and severity of Infectious sequelae result from profound alterations in normal host defenses that occur secondary to the underlying malignanc...
  6. Ophthalmic Involvement in Acquired Immunodeficiency Syndrome

    Ophthalmology 91(9):1092 (1984)

    Forty patients with acquired immunodeficiency syndrome (AIDS) were examined for ocular abnormalities. Twenty of these patients died and the eyes were obtained for culture and histopathologic examination. These patients have multiple opportunistic infections and neoplasms as the result ...
  7. Approaching the controversies in antibacterial management of cancer patients

    The American Journal of Medicine 76(3):436 (1984)

    The principles for management of infectious complications in cancer patients are continuing to evolve. The critical element includes the prompt institution of broad-spectrum antibiotic(s) empirically when granulocytopenic patients become febrile and continuation and modification of the regi...
  8. Transformation of 17 s to 16 s ribosomal RNA using ribonuclease II ofEscherichia coli

    Journal of Molecular Biology 60(2):325 (1971)

    When a mutant, temperature-sensitive in the potassium-dependent RNase II, was cultured at 43 °C, cell growth became linear, and ribosomal precursors of 30 s and 50 s particles accumulated, the former containing the immature 17 s form of 16s ribosomal RNA. In vitro, purified RNase II ...