Development and applications of molecularly imprinted polymers based on hydrophobic CdSe/ZnS quantum dots for optosensing of N(ε)-carboxymethyllysine in foods.
Food Chemistry 211:34 (2016)
A novel molecularly imprinted polymer (MIP) based on hydrophobic CdSe/ZnS quantum dots (HBQDs) was synthesized via an approach that combines MIPs for the selectivity and sensitivity with semiconductor HBQDs as optosensing material (HBQDs@MIP). Here, using a one-pot water-in-oil reverse microemul...
Deliberate self-harm among Chinese medical students: A population-based study.
Journal of Affective Disorders 202:137 (2016)
The phenomenon of deliberate self-harm (DSH) among college students has received increased attention in recent decades. Adopting a psychosocial perspective, this study aims to describe self-reported DSH among Chinese medical college students, assess respective associations between uncertainty st...
Theoretical study on photooxidation mechanism of ruthenium complex [Ru(II)-(bpy)2 (TMBiimH2 )](2+) with molecular oxygen.
Journal Of Computational Chemistry 37(24):2212 (2016)
Photoinduced reactions of ruthenium complexes with molecular oxygen have attracted a lot of experimental attention; however, the reaction mechanism remains elusive. In this work, we have used the density functional theory method to scrutinize the visible-light induced photooxidation mechanism of...
Permeation of sumatriptan succinate across human skin using multiple types of self-dissolving microneedle arrays fabricated from sodium hyaluronate.
Journal of Drug Targeting 24(8):752 (2016)
Available formulations of sumatriptan succinate (SS) have low bioavailability or are associated with site reactions. We developed various types of self-dissolving microneedle arrays (MNs) fabricated from sodium hyaluronate as a new delivery system for SS and evaluated their skin permeation and i...
Mutations of short tandem repeat loci in cases of paternity testing in Chinese.
International Journal of Legal Medicine 130(5):1203 (2016)
In order to find out the characteristics of genetic mutations in 15 short tandem repeat (STR) loci, 3734 parentage cases were analyzed using AmpFlSTR Sinofiler kit. The allele source, mutation rate, and mutation rule of the STR loci were determined. Seventy mutations were observed in all cases f...
Facile fabrication of an electrochemical aptasensor based on magnetic electrode by using streptavidin modified magnetic beads for sensitive and specific detection of Hg(2.).
Biosensors and Bioelectronics 82:9 (2016)
In this work, a novel electrochemical aptasensor was developed for sensitive and specific detection of Hg(2+) based on thymine-Hg(2+)-thymine (T-Hg(2+)-T) structure via application of thionine (Th) as indicator signal. For the fabrication of the aptasensor, streptavidin modified magnetic beads (...
Excited-State Intramolecular Proton Transfer in a Blue Fluorescence Chromophore Induces Dual Emission.
ChemPhysChem 17(15):2340 (2016)
Compared with green fluorescence protein (GFP) chromophores, the recently synthesized blue fluorescence protein (BFP) chromophore variant presents intriguing photochemical properties, for example, dual fluorescence emission, enhanced fluorescence quantum yield, and ultra-slow excited-state intra...
One-Step Modification of Electrode Surface for Ultrasensitive and Highly Selective Detection of Nucleic Acids with Practical Applications.
Analytical chemistry 88(15):7583 (2016)
Electrochemistry-based nucleic acid sensors have long been plagued by the limited accessibility of target molecules to the capture probes immobilized on heterogeneous surfaces, which largely hinders their practical application. In this work, we find that dual-thiolated hairpin DNA immobilized on...
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity.
Cell Research 26(8):967 (2016)
Genetic control and regulatory mechanisms of succinoglycan and curdlan biosynthesis in genus Agrobacterium.
Applied Microbiology and Biotechnology 100(14):6183 (2016)
Agrobacterium is a genus of gram-negative bacteria that can produce several typical exopolysaccharides with commercial uses in the food and pharmaceutical fields. In particular, succinoglycan and curdlan, due to their good quality in high yield, have been employed on an industrial scale comparat...
The Addition of N-Hexanoyl-Homoserine Lactone to Improve the Microbial Flocculant Production of Agrobacterium tumefaciens Strain F2, an Exopolysaccharide Bioflocculant-Producing Bacterium.
Applied Biochemistry and Biotechnology 179(5):728 (2016)
In this study, N-hexanoyl-homoserine lactone (C6-HSL), a member of the N-acyl-homoserine lactone class of microbial quorum sensing (QS) signaling molecules, was used to improve microbial flocculant production. After exogenous C6-HSL was added, exopolysaccharide concentration of microbial floccul...
Nasolacrimal recanalization as an alternative to external dacryocystorhinostomy for treating failed nasolacrimal duct intubation.
Medicine (Baltimore) 95(30):e4350 (2016)
To compare the surgical duration and clinical outcomes of nasolacrimal recanalization versus external dacryocystorhinostomy (DCR) in the treatment of failed nasolacrimal duct intubation.This is a retrospective, comparative, and interventional study. We evaluated the outcomes of 66 consecutive pa...
Electrochemical detection of DNA 3'-phosphatases based on surface-extended DNA nanotail strategy.
Analytica Chimica Acta 924:29 (2016)
Determination of DNA dephosphorylation is of great value due to its vital role in many cellular processes. Here we report a surface-extended DNA nanotail strategy for simple and ultrasensitive detection of DNA 3'-phosphatases by terminal deoxynucleotidyl transferase (TdT) mediated signal amplifi...
N-Phenyl indole derivatives as AT1 antagonists with anti-hypertension activities: Design, synthesis and biological evaluation.
European Journal of Medicinal Chemistry 115:161 (2016)
The design, synthesis, in vitro and in vivo evaluation of 6-substituted benzimidazole with 1, 4-disubsituted or 1, 5-disubsituted indole derivatives as novel angiotensin II receptor antagonists are outlined. Radioligand binding assays showed that several 6-substituted benzimidazole derivatives d...
Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives.
European Journal of Medicinal Chemistry 115:109 (2016)
In an ongoing investigation of 20-sulfonylamidine derivatives (9, YQL-9a) of camptothecin (1) as potential anticancer agents directly and selectively inhibiting topoisomerase (Topo) I, the sulfonylamidine pharmacophore was held constant, and a camptothecin derivatives with various substitution p...
Polarized emission from CsPbX3 perovskite quantum dots.
Nanoscale 8(22):11565 (2016)
Compared to organic/inorganic hybrid perovskites, full inorganic perovskite quantum dots (QDs) exhibit higher stability. In this study, full inorganic CsPbX3 (X = Br, I and mixed halide systems Br/I) perovskite QDs have been synthesized and interestingly, these QDs showed highly polarized photol...
Violent injuries and regional correlates among women in China: results from 21 cities study in China.
European Journal of Public Health 26(3):513 (2016)
Ecological models depict violent injuries against women being influenced by both individual and environmental characteristics. However, only few studies examined the association between regional variables and the likelihood of violent injuries. Our study is a preliminary assessment of the impact...
Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes.
Medicine (Baltimore) 95(24):e3864 (2016)
Carotid intima-media thickness (IMT) has been one widely used index of early carotid atherosclerosis. We speculated that the influence of blood pressure variability (BPV) on early carotid atherosclerosis may be varied by the location of the carotid artery and diabetes history. Thus, the goal of ...
EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC) harboring uncommon EGFR mutations: A real-world study in China.
Lung Cancer 96:87 (2016)
There are a number of uncommon EGFR mutations whose associations with TKIs are not well clarified. Here, we summarize the clinical data of patients with multiple uncommon EGFR mutations and their sensitivity to EGFR TKIs.
Between January 2009 and September 2014, we retrospectively examined stage...
Efficacy of EGFR tyrosine kinase inhibitors for non-adenocarcinoma lung cancer patients harboring EGFR-sensitizing mutations in China.
Journal of Cancer Research and Clinical Oncology 142(6):1325 (2016)
EGFR tyrosine kinase inhibitors (TKIs) have been established as standard therapy for EGFR-mutated adenocarcinomas; for non-adenocarcinoma non-small cell lung cancer (NSCLC) patients, this therapy remains debatable.
Stage IIIB/IV patients with non-adenocarcinoma NSCLC who underwent EGFR testing w...