1. The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse.

    Oncotarget 6(18):15902 (2015) PMID 26079539

    Faced with reduced levels of food, animals must adjust to the consequences of the shortfall in energy. We explored how C57BL/6 mice withdrew energy from different body tissues during three months of food restriction at graded levels up to 40% (calorie restriction: CR). We compared this to the re...
  2. Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy.

    British Journal of Haematology 169(4):574 (2015) PMID 25753210

    Sickle cell disease (SCD) is increasingly appreciated as an inflammatory condition associated with alterations in immune phenotype and function. In this cross-sectional study we performed a multiparameter analysis of 18 immune markers in 114 paediatric SCD patients divided by treatment group [th...
  3. Metabolome-wide association study of phenylalanine in plasma of common marmosets.

    Amino Acids 47(3):589 (2015) PMID 25526869 PMCID PMC4329081

    Little systematic knowledge exists concerning the impacts of cumulative lifelong exposure, termed the exposome, on requirements for nutrients. Phenylalanine (Phe) is an essential dietary amino acid with an aromatic ring structure similar to endogenous metabolites, dietary compounds and environme...
  4. Metabolome-wide association study of phenylalanine in plasma of common marmosets.

    Amino Acids 47(3):589 (2015) PMID 25526869

    Little systematic knowledge exists concerning the impacts of cumulative lifelong exposure, termed the exposome, on requirements for nutrients. Phenylalanine (Phe) is an essential dietary amino acid with an aromatic ring structure similar to endogenous metabolites, dietary compounds and environme...
  5. Metabolome-wide association study of phenylalanine in plasma of common marmosets.

    Amino Acids 47(3):589 (2015) PMID 25526869 PMCID PMC4329081

    Little systematic knowledge exists concerning the impacts of cumulative lifelong exposure, termed the exposome, on requirements for nutrients. Phenylalanine (Phe) is an essential dietary amino acid with an aromatic ring structure similar to endogenous metabolites, dietary compounds and environme...
  6. Metabolome-wide association study of phenylalanine in plasma of common marmosets.

    Amino Acids 47(3):589 (2015) PMID 25526869

    Little systematic knowledge exists concerning the impacts of cumulative lifelong exposure, termed the exposome, on requirements for nutrients. Phenylalanine (Phe) is an essential dietary amino acid with an aromatic ring structure similar to endogenous metabolites, dietary compounds and environme...
  7. Fertile waters for aging research.

    Cell 160(5):814 (2015) PMID 25723160

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring t...
  8. Fertile waters for aging research.

    Cell 160(5):814 (2015) PMID 25723160

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring t...
  9. MetabNet: An R Package for Metabolic Association Analysis of High-Resolution Metabolomics Data.

    Frontiers in bioengineering and biotechnology 3:87 (2015) PMID 26125020 PMCID PMC4464066

    Liquid-chromatography high-resolution mass spectrometry provides capability to measure >40,000 ions derived from metabolites in biologic samples. This presents challenges to confirm identities of known chemicals and delineate potential metabolic pathway associations of unidentified chemicals. We...
  10. Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.

    Aging Cell 13(4):596 (2014) PMID 24636523 PMCID PMC4116462

    Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or li...
  11. Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.

    Aging Cell 13(4):596 (2014) PMID 24636523 PMCID PMC4116462

    Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or li...
  12. Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.

    Aging Cell 13(4):596 (2014) PMID 24636523 PMCID PMC4116462

    Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or li...
  13. Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.

    Aging Cell 13(4):596 (2014) PMID 24636523 PMCID PMC4116462

    Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or li...
  14. Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.

    Aging Cell 13(4):596 (2014) PMID 24636523 PMCID PMC4116462

    Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or li...
  15. Development. Chemical warfare in the battle of the sexes.

    Science 343(6170):491 (2014) PMID 24482469

  16. Development. Chemical warfare in the battle of the sexes.

    Science 343(6170):491 (2014) PMID 24482469

  17. Development. Chemical warfare in the battle of the sexes.

    Science 343(6170):491 (2014) PMID 24482469

  18. Invariance and plasticity in the Drosophila melanogaster metabolomic network in response to temperature.

    BMC Systems Biology 8(1):139 (2014) PMID 25540032 PMCID PMC4302152

    Metabolomic responses to extreme thermal stress have recently been investigated in Drosophila melanogaster. However, a network level understanding of metabolomic responses to longer and less drastic temperature changes, which more closely reflect variation in natural ambient temperatures experie...
  19. Robert L. Perlman, evolution & medicine.

    Evolution, Medicine, and Public Health 2014(1):10 (2014) PMID 24481245 PMCID PMC4204620

  20. Robert L. Perlman, evolution & medicine.

    Evolution, Medicine, and Public Health 2014(1):10 (2014) PMID 24481245 PMCID PMC4204620