1. MicroRNAs in skin tissue engineering.

    Advanced Drug Delivery Reviews 88:16 (2015) PMID 25953499

    35.2 million annual cases in the U.S. require clinical intervention for major skin loss. To meet this demand, the field of skin tissue engineering has grown rapidly over the past 40years. Traditionally, skin tissue engineering relies on the "cell-scaffold-signal" approach, whereby isolated cells...
  2. Limb contribution to increased self-selected walking speeds during body weight support in individuals poststroke.

    Gait & Posture 41(3):857 (2015) PMID 25770079 PMCID PMC4408234

    Individuals poststroke walk at faster self-selected speeds under some nominal level of body weight support (BWS) whereas nonimpaired individuals walk slower after adding BWS. The purpose of this study was to determine whether increases in self-selected overground walking speed under BWS conditio...
  3. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells.

    Neuron 85(2):346 (2015) PMID 25578363 PMCID PMC4306544

    Acetylcholine critically influences hippocampal-dependent learning. Cholinergic fibers innervate hippocampal neuron axons, dendrites, and somata. The effects of acetylcholine on axonal information processing, though, remain unknown. By stimulating cholinergic fibers and making electrophysiologic...
  4. Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.

    PLoS ONE 10(6):e0131389 (2015) PMID 26114426 PMCID PMC4482723

    The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders. However, the temporal dynamics of kynurenine pa...
  5. Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

    PLoS ONE 10(7):e0133362 (2015) PMID 26207898 PMCID PMC4514813

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in t...
  6. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice.

    PLoS ONE 10(2):e0115189 (2015) PMID 25695521

    The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely ...
  7. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice.

    PLoS ONE 10(2):e0115189 (2015) PMID 25695521 PMCID PMC4335046

    The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely ...
  8. Characteristics of horizontal force generation for individuals post-stroke walking against progressive resistive forces.

    Clinical Biomechanics 30(1):40 (2015) PMID 25481856

    Walking, while experiencing horizontal resistive forces, can allow researchers to assess characteristics of force generation in a task specific manner for individuals post-stroke. Ten neurologically nonimpaired individuals (mean age 52 years) and fourteen chronic stroke survivors (mean age 54 ye...
  9. Characteristics of horizontal force generation for individuals post-stroke walking against progressive resistive forces.

    Clinical Biomechanics 30(1):40 (2015) PMID 25481856 PMCID PMC4362732

    Walking, while experiencing horizontal resistive forces, can allow researchers to assess characteristics of force generation in a task specific manner for individuals post-stroke. Ten neurologically nonimpaired individuals (mean age 52 years) and fourteen chronic stroke survivors (mean age 54 ye...
  10. N-3 Polyunsaturated Fatty Acids, Lipid Microclusters, and Vitamin E.

    Current Topics in Membranes 75:209 (2015) PMID 26015284

    Increased consumption of long-chain marine n-3 polyunsaturated fatty acids (PUFA) has potential health benefits for the general population and for select clinical populations. However, several key limitations remain in making adequate dietary recommendations on n-3 PUFAs in addition to translati...
  11. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice.

    PLoS ONE 10(2):e0115189 (2015) PMID 25695521 PMCID PMC4335046

    The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely ...
  12. Effect of progressive horizontal resistive force on the comfortable walking speed of individuals post-stroke.

    Journal of NeuroEngineering and Rehabilitation 12(1):12 (2015) PMID 25884953 PMCID PMC4329221

    Individuals post-stroke select slow comfortable walking speeds (CWS) and the major factors used to select their CWS is unknown. To determine the extent to which slow CWS post-stroke is achieved through matching a relative force output or targeting a particular walking speed. Ten neurologically n...
  13. The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.

    PLoS ONE 10(4):e0123399 (2015) PMID 25867953 PMCID PMC4395016

    Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) is a divergent transforming growth factor - beta (TGF-β) superfamily cytokine. To uncover the un...
  14. Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.

    Frontiers in Physiology 6:161 (2015) PMID 26042050 PMCID PMC4436568

    Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role of ischemic endogenous cells in this context. We hypothesized that ischemic...
  15. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

    PLoS ONE 10(2):e0115189 (2015) PMID 25695521 PMCID PMC4335046

    The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely ...
  16. Increasing mitochondrial membrane phospholipid content lowers the enzymatic activity of electron transport complexes.

    Biochemistry (Washington) 53(35):5589 (2014) PMID 25145682

    Activities of the enzymes involved in cellular respiration are markedly influenced by the composition of the phospholipid environment of the inner mitochondrial membrane. Contrary to previous suppositions, we show that fusion of mitochondria isolated from healthy cardiac muscle with cardiolipin ...
  17. Increasing mitochondrial membrane phospholipid content lowers the enzymatic activity of electron transport complexes.

    Biochemistry (Washington) 53(35):5589 (2014) PMID 25145682

    Activities of the enzymes involved in cellular respiration are markedly influenced by the composition of the phospholipid environment of the inner mitochondrial membrane. Contrary to previous suppositions, we show that fusion of mitochondria isolated from healthy cardiac muscle with cardiolipin ...
  18. Increasing levels of cardiolipin differentially influence packing of phospholipids found in the mitochondrial inner membrane

    Biochemical and Biophysical Research Communicat... 450(1):366 (2014)

    • The effects of CL on membrane packing are contradictory. • CL increases packing dose-dependently in loosely packed DOPC/DOPE vesicles. ...
  19. Increasing levels of cardiolipin differentially influence packing of phospholipids found in the mitochondrial inner membrane.

    Biochemical and Biophysical Research Communicat... 450(1):366 (2014) PMID 24905496

    It is essential to understand the role of cardiolipin (CL) in mitochondrial membrane organization given that changes in CL levels contribute to mitochondrial dysfunction in type II diabetes, ischemia-reperfusion injury, heart failure, breast cancer, and aging. Specifically, there are contradicto...
  20. Analysis of feedback control of piezoelectric transducers.

    Journal of the Acoustical Society of America 135(6):3425 (2014) PMID 24907806

    Velocity control feedback may be required for implementation in large underwater acoustic arrays to mitigate the effects of strong acoustic field coupling when specific beam pattern performance over a variety of operating conditions is desired. This paper presents an analysis of velocity control...