1. Trends in opioid analgesic abuse and mortality in the United States.

    New England Journal of Medicine 372(16):1572 (2015) PMID 25875269

  2. A novel, nonbinary evaluation of success and failure reveals bupropion efficacy versus methamphetamine dependence: reanalysis of a multisite trial.

    CNS Neuroscience & Therapeutics 18(5):414 (2012) PMID 22070720

    A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetam...
  3. A novel, nonbinary evaluation of success and failure reveals bupropion efficacy versus methamphetamine dependence: reanalysis of a multisite trial.

    CNS Neuroscience & Therapeutics 18(5):414 (2012) PMID 22070720

    A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetam...
  4. Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.

    Experimental and Clinical Psychopharmacology 19(1):1 (2011) PMID 21341918 PMCID PMC3392967

    The effectiveness of methadone as a treatment for opioid abuse and nicotine preparations as treatments for tobacco smoking has led to an interest in developing a similar strategy for treating psychostimulant abuse. The current study investigated the effects of three such potential therapies on i...
  5. Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.

    Experimental and Clinical Psychopharmacology 19(1):1 (2011) PMID 21341918 PMCID PMC3392967

    The effectiveness of methadone as a treatment for opioid abuse and nicotine preparations as treatments for tobacco smoking has led to an interest in developing a similar strategy for treating psychostimulant abuse. The current study investigated the effects of three such potential therapies on i...
  6. Drugs of abuse: management of intoxication and antidotes.

    EXS 100:519 (2010) PMID 20358694

    Illicit drug intoxications are an increasing public health problem for which, in most cases, no antidotes are clinically available. The diagnosis and treatment of these intoxications requires a trained clinician with experience in recognizing the specific signs and symptoms of intoxications to i...
  7. Drugs of abuse: management of intoxication and antidotes.

    EXS 100:519 (2010) PMID 20358694

    Illicit drug intoxications are an increasing public health problem for which, in most cases, no antidotes are clinically available. The diagnosis and treatment of these intoxications requires a trained clinician with experience in recognizing the specific signs and symptoms of intoxications to i...
  8. Summary of NIDA medications workshop: new opportunities for chemists and pharmacologists.

    Drug and Alcohol Dependence 92(1-3):307 (2008) PMID 18286704

  9. Summary of NIDA medications workshop: new opportunities for chemists and pharmacologists.

    Drug and Alcohol Dependence 92(1-3):307 (2008) PMID 18286704

  10. Rash and fever.

    The Journal of Emergency Medicine 31(3):293 (2006) PMID 16982364

  11. Rash and fever.

    The Journal of Emergency Medicine 31(3):293 (2006) PMID 16982364

  12. Rash and fever

    The Journal of Emergency Medicine 31(3):293 (2006)

  13. Sixth cranial nerve palsy.

    The Journal of Emergency Medicine 29(2):207 (2005) PMID 16029834

  14. Sixth cranial nerve palsy.

    The Journal of Emergency Medicine 29(2):207 (2005) PMID 16029834

  15. Sixth cranial nerve palsy

    The Journal of Emergency Medicine 29(2):207 (2005)

  16. An absence of changes in σ receptor subtypes in the brains of genetically dystonic (dt) rats

    European Journal of Pharmacology 250(2):329 (1993)

    Binding sites for the σ ligand [ 3 H] di-o- tollylguanidine [ 3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective σ 1 and σ 2 assay conditions were utilized in an eff...
  17. Tris inhibits (+)-[3H]SKF-10,047 binding to σ receptors

    Neuroscience Letters 141(2):239 (1992)

    Tris-HCl is the most commonly used buffer in studies of radioligand binding to σ receptors, with concentrations as high as 50 or 100 mM often used. We report here that these concentrations of Tris substantially inhibit (+)-[ 3H]SKF-10,047 binding to σ receptors. The well-established i...
  18. Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

    European Journal of Pharmacology: Molecular Pha... 188(4):211 (1990)

    The distribution of haloperidol-sensitive (+)[ 3H]N-allylnormetazocine ((+)[ 3H]SKF-10,047) binding sites (σ sites) in subcellular fractions of rat brain homogenates was extensively characterized. In synaptosomal fractions, enriched in choline acetyltransferase activity, σ sites...
  19. Haloperidol competitively inhibits the binding of (+)-[3H]SKF-10,047 to σ sites

    European Journal of Pharmacology 180(2):361 (1990)

    Scatchard plots of equilibrium saturation binding data revealed that haloperidol inhibits the binding of (+)-[ 3H]SKF-10,047 to σ sites in a competitive manner. In experiments using membranes from both guinea pig and rat brain the apparent K d of (+)-[ 3H]SKF-10,047 for σ ...
  20. Phencyclidine/SKF-10,047 binding sites: Evaluation of function

    Pharmacology Biochemistry and Behavior 32(1):87 (1989) PMID 2543993

    Results of correlation analyses comparing rank-order affinities with rank-order potencies of (+)SKF-10,047, phencyclidine (PCP), and several PCP analogs support the involvement of [ 3H]-1-[1-(2-thienyl)cyclohexyl]piperidine binding sites (TCP sites) in mediating both the discriminativ...