1. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

    Blood 127(25):3215 (2016) PMID 27069256 PMCID PMC4920022

    BCL2 blunts activation of the mitochondrial pathway to apoptosis, and high-level expression is required for chronic lymphocytic leukemia (CLL) survival. Venetoclax (ABT-199) is a small-molecule selective inhibitor of BCL2 currently in clinical trials for CLL and other malignancies. In conjunctio...
  2. A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus.

    Journal of Controlled Release 209:47 (2015) PMID 25910578

    Implant-associated bone infections caused by antibiotic-resistant pathogens pose significant clinical challenges to treating physicians. Prophylactic strategies that act against resistant organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are urgently required. In the present...
  3. Simplified silvestrol analogues with potent cytotoxic activity.

    Chemmedchem 9(7):1556 (2014) PMID 24677741

    The complex natural products silvestrol (1) and episilvestrol (2) are inhibitors of translation initiation through binding to the DEAD-box helicase eukaryotic initiation factor 4A (eIF4A). Both compounds are potently cytotoxic to cancer cells in vitro, and 1 has demonstrated efficacy in vivo in ...
  4. Further insights into the effects of pre-organizing the BimBH3 helix.

    ACS Chemical Biology 9(3):838 (2014) PMID 24547872

  5. Online medicine for pregnant women.

    International Journal of Telemedicine and Appli... 2014:379427 (2014) PMID 25132848 PMCID PMC4122028

    Objective. To assess the use of cell phones and email as means of communication between pregnant women and their gynecologists and family physicians. Study Design. A cross-sectional study of pregnant women at routine followup. One hundred and twenty women participated in the study. Results. The ...
  6. The vagina dialogues: genital self-image and communication with physicians about sexual dysfunction and dissatisfaction among Jewish patients in a women's health clinic in southern Israel.

    Journal of Sexual Medicine 10(12):3059 (2013) PMID 24112414

    The health-care system offers a variety of solutions for problems related to sexual dysfunction. To gain access to treatment options, women must be willing to discuss these issues with their physicians. To examine the extent to which women discuss issues of sexual dysfunction with their physicia...
  7. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

    Journal of Neuroscience 33(1):315 (2013) PMID 23283344 PMCID PMC3640269

    Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly and selecti...
  8. The Use of JAK-specific inhibitors as chemical biology tools.

    Methods in Molecular Biology 967:99 (2013) PMID 23296724

    The JAK family of protein tyrosine kinases are now recognized as important participants in a wide range of pathologies, from cancer to inflammatory diseases. In the last decade, the drive to develop drugs targeting members of this family has begun to deliver a panel of small molecule inhibitors ...
  9. Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue.

    Organic & Biomolecular Chemistry 10(40):8147 (2012) PMID 22964776

    The first synthesis of a lactam analogue of salicylihalamide A (1) is reported. A key step in the approach was a photochemical acylation coupling between amine 10 and dioxinone 9 to form the amide 19. Acetylation followed by RCM with Grubbs 1st generation catalyst gave the desired E-lactam 23 (E...
  10. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.

    Blood 120(4):822 (2012) PMID 22689861 PMCID PMC3709628

    Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation ...
  11. A lipid-and-polymer-based novel local drug delivery system—BonyPid™: From physicochemical aspects to therapy of bacterially infected bones

    Journal of Controlled Release 160(2):353 (2012) PMID 22507550

    Bacterial infection of bone may result in bone destruction and is difficult to cure due to poor accessibility to bone of systemically-administrated antibiotic and poor performance of currently available local antibacterial treatments. We developed a novel local drug delivery system bas...
  12. A lipid-and-polymer-based novel local drug delivery system—BonyPid™: From physicochemical aspects to therapy of bacterially infected bones

    Journal of Controlled Release 160(2):353 (2012) PMID 22507550

    Bacterial infection of bone may result in bone destruction and is difficult to cure due to poor accessibility to bone of systemically-administrated antibiotic and poor performance of currently available local antibacterial treatments. We developed a novel local drug delivery system bas...
  13. Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.

    PAIN® 153(4):876 (2012) PMID 22341563 PMCID PMC3319437

    Inflammatory pain impacts adversely on the quality of life of patients, often resulting in motor disabilities. Therefore, we studied the effect of peripheral inflammation induced by intraplantar administration of complete Freund's adjuvant (CFA) in mice on a particular form of voluntary locomoti...
  14. Delay in diagnosis of primary intradural spinal cord tumors.

    Surgical Neurology International 3:52 (2012) PMID 22629489 PMCID PMC3356987

    It has been our impression in recent years that there is a significant delay in diagnosis (DID) of patients in Israel harboring intradural spinal cord tumors (IDSCTs). DID can lead to irreversible deficits and unnecessary suffering. Our goal was to identify the incidence and the specific reasons...
  15. The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes.

    Biologics Targets & Therapy 6:67 (2012) PMID 22532774 PMCID PMC3333821

    We have previously demonstrated that the small leucine-rich proteoglycan decorin may play a role in adipose tissue homeostasis and the pathophysiology of obesity. Biglycan is highly similar in structure to decorin, therefore we hypothesized it would have a similar expression profile and role to ...
  16. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo.

    Journal of Pharmacology and Experimental Therap... 339(3):799 (2011) PMID 21917561

    The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea (CYT997), reported previously by us (Bioorg Med Chem Lett 19:4639-4642, 2009; Mol Cancer Ther 8:3036-3045, 2009), is potently cytotoxic to a variety of c...
  17. Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.

    Diabetes 60(6):1813 (2011) PMID 21617188 PMCID PMC3114383

    Two novel mutations (E1506D, E1506G) in the nucleotide-binding domain 2 (NBD2) of the ATP-sensitive K(+) channel (K(ATP) channel) sulfonylurea receptor 1 (SUR1) subunit were detected heterozygously in patients with neonatal diabetes. A mutation at the same residue (E1506K) was previously shown t...
  18. The effect of hyaluronan injections into human knees on the number of bone and cartilage wear particles captured by bio-ferrography.

    Acta Biomaterialia 7(2):848 (2011) PMID 20826234

    Osteoarthritis is characterized by degradation of cartilage and subchondral bone, releasing wear particles into the synovial fluid. Intra-articular injections of exogenous hyaluronan are often given to patients suffering from osteoarthritis in order to compensate for the reduction in the level o...
  19. Omacetaxine as an anticancer therapeutic: what is old is new again.

    Current Pharmaceutical Design 17(1):59 (2011) PMID 21294709

    Omacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) showed promising activity. It has also been studied in other hematologic and solid tumors as both a single agent and in combination with other treatments. However, the...
  20. Electronic fall surveillance system model.

    Health Care Manager 30(4):342 (2011) PMID 22042142

    Of primary concern to health care facilities today is the reduction of preventable injuries such as patient falls that often lead to serious and fatal injuries and result in increased lengths of stays, resource demands, costs, and lawsuits. Although all patients have the capacity to fall, a majo...