1. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.

    Journal of Hepatology 65(2):325 (2016) PMID 27117591

    Pediatric liver cancer is a rare but serious disease whose incidence is rising, and for which the therapeutic options are limited. Development of more targeted, less toxic therapies is hindered by the lack of an experimental animal model that captures the heterogeneity and metastatic capability ...
  2. Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases.

    Scientific reports 6:21264 (2016) PMID 26887909 PMCID PMC4757933

    Efficient gene editing is essential to fully utilize human pluripotent stem cells (hPSCs) in regenerative medicine. Custom endonuclease-based gene targeting involves two mechanisms of DNA repair: homology directed repair (HDR) and non-homologous end joining (NHEJ). HDR is the preferred mechanism...
  3. The role of microRNAs in prostate cancer progression.

    Translational andrology and urology 2(3):228 (2013) PMID 26813625 PMCID PMC4708182

    Prostate cancer (PCa) is the most common male malignancy and the second highest cause of cancer-related mortality in United States. MicroRNAs (miRNAs) are small non-coding RNAs that represent a new mechanism to regulate mRNA post-transcriptionally. It is involved in diverse physiological and pat...
  4. In vitropercutaneous absorption and stratum corneum binding of alachlor: Effect of formulation dilution with water

    Toxicology and Applied Pharmacology 100(3):417 (1989)

    The effect of vehicle dilution on the percutaneous absorption of alachlor, 2-chloro-2′,6′-diethyl- N-(methoxymethyl)acetanilide, through excised human skin was determined using flowthrough design glass penetration cells and 14C radiotracer methodology. Three dilutions of alachl...