1. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

    EMBO Journal 34(12):1612 (2015) PMID 25896511 PMCID PMC4475397

    Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, called "microgliopathies". However, how the intracellular stimu...
  2. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.

    Nature Immunology 16(1):67 (2015) PMID 25419628 PMCID PMC4320687

    Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus. Setdb2 expression depended on signaling via type I interferons, and ...
  3. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.

    Nature Immunology 16(1):67 (2015) PMID 25419628 PMCID PMC4320687

    Immune responses are tightly regulated to ensure efficient pathogen clearance while avoiding tissue damage. Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus. Setdb2 expression depended on signaling via type I interferons, and ...
  4. Pervasive axonal transport deficits in multiple sclerosis models.

    Neuron 84(6):1183 (2014) PMID 25433639

    Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration-whether, when, and how axonal transport is affected in t...
  5. Pervasive axonal transport deficits in multiple sclerosis models.

    Neuron 84(6):1183 (2014) PMID 25433639

    Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration-whether, when, and how axonal transport is affected in t...
  6. Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

    Neuron 84(6):1183 (2014) PMID 25433639

    Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration—whether, when, and how axonal transport is aff...
  7. Oxysterols promote encephalitogenic CD4 + T cell migration during neuroinflammation

    Journal of Neuroimmunology 275(1-2):169 (2014)

  8. Oxysterols are expressed in T lymphocytes and impair type 1 regulatory CD4 T-cell differentiation

    Journal of Neuroimmunology 275(1-2):206 (2014)

  9. Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.

    Journal of Immunology 193(6):2743 (2014) PMID 25114100

    Autoimmune neuroinflammation, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), a prototype for T cell-mediated autoimmunity, is believed to result from immune tolerance dysfunction leading to demyelination and substantial neurodegeneration. We p...
  10. Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.

    Journal of Immunology 193(6):2743 (2014) PMID 25114100

    Autoimmune neuroinflammation, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), a prototype for T cell-mediated autoimmunity, is believed to result from immune tolerance dysfunction leading to demyelination and substantial neurodegeneration. We p...
  11. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination.

    Acta Neuropathologica 128(2):231 (2014) PMID 24563023 PMCID PMC4102825

    Cerebral cortex shows a high endogenous propensity for remyelination. Yet, widespread subpial cortical demyelination (SCD) is a common feature in progressive multiple sclerosis (MS) and can already be found in early MS. In the present study, we compared oligodendroglial loss in SCD in early and ...
  12. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination.

    Acta Neuropathologica 128(2):231 (2014) PMID 24563023 PMCID PMC4102825

    Cerebral cortex shows a high endogenous propensity for remyelination. Yet, widespread subpial cortical demyelination (SCD) is a common feature in progressive multiple sclerosis (MS) and can already be found in early MS. In the present study, we compared oligodendroglial loss in SCD in early and ...
  13. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination.

    Acta Neuropathologica 128(2):231 (2014) PMID 24563023 PMCID PMC4102825

    Cerebral cortex shows a high endogenous propensity for remyelination. Yet, widespread subpial cortical demyelination (SCD) is a common feature in progressive multiple sclerosis (MS) and can already be found in early MS. In the present study, we compared oligodendroglial loss in SCD in early and ...
  14. Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.

    CNS Drugs 28(6):535 (2014) PMID 24723124 PMCID PMC4057629

    Multiple sclerosis (MS) is a life-long, potentially debilitating disease of the central nervous system (CNS). MS is considered to be an immune-mediated disease, and the presence of autoreactive peripheral lymphocytes in CNS compartments is believed to be critical in the process of demyelination ...
  15. Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.

    CNS Drugs 28(6):535 (2014) PMID 24723124 PMCID PMC4057629

    Multiple sclerosis (MS) is a life-long, potentially debilitating disease of the central nervous system (CNS). MS is considered to be an immune-mediated disease, and the presence of autoreactive peripheral lymphocytes in CNS compartments is believed to be critical in the process of demyelination ...
  16. Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.

    CNS Drugs 28(6):535 (2014) PMID 24723124 PMCID PMC4057629

    Multiple sclerosis (MS) is a life-long, potentially debilitating disease of the central nervous system (CNS). MS is considered to be an immune-mediated disease, and the presence of autoreactive peripheral lymphocytes in CNS compartments is believed to be critical in the process of demyelination ...
  17. Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

    Cell 156(1-2):277 (2014)

    Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy, and genetics, we...
  18. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue.

    Cell 156(1-2):277 (2014) PMID 24439382

    Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy, and genetics, we show that...
  19. TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3+ Treg cells.

    European Journal of Immunology 44(1):46 (2014) PMID 24018482

    The innate Toll-like receptor 7 (TLR7) detects infections by recognizing viral and bacterial single-stranded RNA. In addition to pathogen-derived RNA, immune cells expressing high levels of TLR7, such as B cells and dendritic cells (DCs), can be activated by self-RNA. During myelin-induced exper...
  20. TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3+ Treg cells.

    European Journal of Immunology 44(1):46 (2014) PMID 24018482

    The innate Toll-like receptor 7 (TLR7) detects infections by recognizing viral and bacterial single-stranded RNA. In addition to pathogen-derived RNA, immune cells expressing high levels of TLR7, such as B cells and dendritic cells (DCs), can be activated by self-RNA. During myelin-induced exper...