1. SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.

    Cancer Immunology Research 3(7):727 (2015) PMID 25649351

    Suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway and generally function as tumor suppressors. The absence of SOCS3 in particular leads to heightened activation of the STAT3 transcription factor, which has a striking ability to promote tumor surviva...
  2. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  3. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  4. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  5. Linking adiponectin and autophagy in the regulation of breast cancer metastasis.

    Klinische Wochenschrift 92(10):1015 (2014) PMID 24903246 PMCID PMC4197061

    Adipokines within the tumor microenvironment may play important roles in regulating the early steps of breast cancer metastasis. Adiponectin (AdipoQ) is the most abundant adipokine and exists in multiple forms: full-length multimers (fAd) and a cleaved, globular isoform (gAd). While these isofor...
  6. Linking adiponectin and autophagy in the regulation of breast cancer metastasis.

    Klinische Wochenschrift 92(10):1015 (2014) PMID 24903246 PMCID PMC4197061

    Adipokines within the tumor microenvironment may play important roles in regulating the early steps of breast cancer metastasis. Adiponectin (AdipoQ) is the most abundant adipokine and exists in multiple forms: full-length multimers (fAd) and a cleaved, globular isoform (gAd). While these isofor...
  7. Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.

    PLoS ONE 9(3):e92919 (2014) PMID 24651853 PMCID PMC3961437

    New therapies are needed for metastatic breast cancer patients. Oncolytic herpes simplex virus (oHSV) is an exciting therapy being developed for use against aggressive tumors and established metastases. Although oHSV have been demonstrated safe in clinical trials, a lack of sufficient potency ha...
  8. Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.

    PLoS ONE 9(3):e92919 (2014) PMID 24651853 PMCID PMC3961437

    New therapies are needed for metastatic breast cancer patients. Oncolytic herpes simplex virus (oHSV) is an exciting therapy being developed for use against aggressive tumors and established metastases. Although oHSV have been demonstrated safe in clinical trials, a lack of sufficient potency ha...
  9. Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

    PLoS ONE 8(6):e68348 (2013) PMID 23840849 PMCID PMC3696014

    Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetic...
  10. Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

    PLoS ONE 8(6):e68348 (2013) PMID 23840849 PMCID PMC3696014

    Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetic...
  11. Unraveling the 'TGF-β paradox' one metastamir at a time.

    Breast Cancer Research (Online Edition) 15(1):305 (2013) PMID 23448381 PMCID PMC3672695

    Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performe...
  12. The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.

    PLoS ONE 8(2):e55966 (2013) PMID 23390556 PMCID PMC3563580

    Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that suppresses metastasis in multiple human and murine carcinoma cell lines. BRMS1 interacts with several nuclear proteins including SIN3:HDAC chromatin remodeling complexes that are involved in repressing transcri...
  13. Unraveling the 'TGF-β paradox' one metastamir at a time.

    Breast Cancer Research (Online Edition) 15(1):305 (2013) PMID 23448381 PMCID PMC3672695

    Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performe...
  14. The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.

    PLoS ONE 8(2):e55966 (2013) PMID 23390556 PMCID PMC3563580

    Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that suppresses metastasis in multiple human and murine carcinoma cell lines. BRMS1 interacts with several nuclear proteins including SIN3:HDAC chromatin remodeling complexes that are involved in repressing transcri...
  15. Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes.

    Cancer and Metastasis Reviews 31(3-4):641 (2012) PMID 22678236

    Epigenetic regulation of gene transcription by histone modification and chromatin remodeling has been linked to many biological and pathological events including cancer metastasis. Breast cancer metastasis suppressor 1 (BRMS1) interacts with SIN3 chromatin remodeling complexes, and, upon forced ...
  16. Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes.

    Cancer and Metastasis Reviews 31(3-4):641 (2012) PMID 22678236

    Epigenetic regulation of gene transcription by histone modification and chromatin remodeling has been linked to many biological and pathological events including cancer metastasis. Breast cancer metastasis suppressor 1 (BRMS1) interacts with SIN3 chromatin remodeling complexes, and, upon forced ...
  17. Clinical significance of KISS1 protein expression for brain invasion and metastasis.

    Cancer 118(8):2096 (2012) PMID 21928364 PMCID PMC3674482

    Metastases to the brain represent a feared complication and contribute to the morbidity and mortality of breast cancer. Despite improvements in therapy, prognostic factors for development of metastases are lacking. KISS1 is a metastasis suppressor that demonstrates inhibition of metastases forma...
  18. Clinical significance of KISS1 protein expression for brain invasion and metastasis.

    Cancer 118(8):2096 (2012) PMID 21928364 PMCID PMC3674482

    Metastases to the brain represent a feared complication and contribute to the morbidity and mortality of breast cancer. Despite improvements in therapy, prognostic factors for development of metastases are lacking. KISS1 is a metastasis suppressor that demonstrates inhibition of metastases forma...
  19. Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.

    Clinical & Experimental Metastasis 29(4):315 (2012) PMID 22241150 PMCID PMC3660968

    Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells are able to spread to distant sites and proliferate to become secondary lesions. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to ide...
  20. Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.

    Clinical & Experimental Metastasis 29(4):315 (2012) PMID 22241150 PMCID PMC3660968

    Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells are able to spread to distant sites and proliferate to become secondary lesions. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to ide...