1. 18-ORdoi="10.1016/j.humimm.2013.08.029" aid="9232.18":INCIDENCE OF HLA ANTIBODIES AFTER ISLET CELL TRANSPLANTATION: INITIAL RESULTS OF THE CLINICAL ISLET TRANSPLANTATION (CIT) CONSORTIUM TRIAL

    Human Immunology 74:15 (2013)

    Aim Alloreactivity to pancreatic islet cell transplantation (IT) has been reported previously particularly for those IT recipients with a history of sensitization events prior to transplant. The aim of this CIT Consortium study was to determine the incidence of HLA alloimmuni...
  2. Immunologic consequences of chemotherapy for acute myeloid leukemia.

    Journal of Pediatric Hematology/Oncology 35(1):46 (2013) PMID 23018569 PMCID PMC3526680

    There are few data characterizing the immunologic consequences of chemotherapy for acute myeloid leukemia (AML) and almost nothing is known about the effects of chemotherapy in a pediatric AML cohort. We identified T-cell subsets, B-cell subsets, and used Enzyme-linked immunosorbent spot analyse...
  3. Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.

    Clinical Cancer Research 18(24):6732 (2012) PMID 23092876

    Children with high-risk neuroblastoma have a poor prognosis with chemotherapy alone, and hematopoietic stem cell transplantation offers improved survival. As a dose-escalation strategy, tandem transplants have been used, but are associated with persistent immunocompromise. This study evaluated t...
  4. Lenalidomide therapy in treatment-refractory cutaneous lupus erythematosus: histologic and circulating leukocyte profile and potential risk of a systemic lupus flare.

    Journal of the American Academy of Dermatology 66(4):571 (2012) PMID 21821308 PMCID PMC3306524

    Lenalidomide is a thalidomide analogue that may serve as an adjunctive therapy for treatment-refractory cutaneous lupus erythematosus (CLE). We evaluate the use of lenalidomide in CLE and describe the skin and circulating leukocyte profile of treatment-refractory patients before and after treatm...
  5. A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22q11.2 deletion syndrome (digeorge syndrome/velocardiofacial syndrome).

    Journal of Clinical Immunology 31(6):927 (2011) PMID 21863400

    Prior to the advent of cardiac bypass, most children with congenital cardiac anomalies and chromosome 22q11.2 deletion syndrome died. With improved technology, there is now a wave of young adults with chromosome 22q11.2 deletion syndrome requiring clinical care. Fifteen young children and 20 adu...
  6. Alternative mechanisms of receptor editing in autoreactive B cells.

    PNAS 108(17):7125 (2011) PMID 21471456 PMCID PMC3084116

    Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg residues of the antibody complementarity determining region (CDR) and the negatively charged phosphate groups of DNA. The importance of A...
  7. Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.

    Blood 117(1):63 (2011) PMID 20864577 PMCID PMC3037760

    Severe immune deficiency follows autologous stem cell transplantation for multiple myeloma and is associated with significant infectious morbidity. This study was designed to evaluate the utility of a pretransplantation vaccine and infusion of a primed autologous T-cell product in stimulating sp...
  8. Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation.

    Nephrology Dialysis Transplantation 23(1):390 (2008) PMID 17956891

  9. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

    Nature Medicine 13(11):1295 (2007) PMID 17965721

    We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
  10. Exogenous and endogenous TLR ligands activate anti-chromatin and polyreactive B cells.

    Journal of Immunology 176(11):6491 (2006) PMID 16709806

    Autoreactive B cells may become activated in a T-independent manner via synergistic engagement of the BCR and TLRs. Using the VH3H9 Ig H chain transgene to track anti-chromatin B cells, we demonstrate that VH3H9/Vlambda1 anti-chromatin B cells proliferate in response to stimulatory oligodeoxynuc...
  11. 22-OR:Temporal decline in islet graft function coincides with the appearance of donor-specific anti-HLA antibodies in an islet transplant recipient

    Human Immunology 67:S25 (2006)

  12. 71-P:A longitudinal analysis of transplant recipients treated with rituximab (anti-CD20): B cell ablation is not effective in depleting pre-existing anti-HLA class I or class II antibodies

    Human Immunology 67:S102 (2006)

  13. Antibody-mediated rejection in heart transplant recipients: potential efficacy of B-cell depletion and antibody removal.

    Clinical transplants :489 (2006) PMID 18365409

    We present four patients with late AMR following cardiac transplantation, which was associated with de novo post-transplant anti-HLA class II antibody production. All patients had negative anti-HLA class I and class II antibodies prior to transplantation (as assessed by sensitive Flow PRA bead a...
  14. Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function.

    Kidney International 66(3):1187 (2004) PMID 15327416

    The unique distribution of the alleles for the Duffy antigen receptor complex (DARC) that binds to chemokines may be associated with the rates of acute rejection and delayed allograft function (DGF) among African Americans. A prospective, multicenter cohort study enrolled 222 African American re...
  15. Regulation of anti-phosphatidylserine antibodies.

    Immunity 18(2):185 (2003) PMID 12594946

    The degree of heavy chain (H) editing, the types of Vkappa editors, and the pattern of Jkappa usage are correlated with a range of the affinity of anti-DNA. This range was determined by the number and location of arginine (R) residues in the VH. We, here, changed a key arginine residue in the VH...
  16. Rapid primary kidney graft loss in a historically sensitized patient despite negative current sample crossmatch by cytometry

    Human Immunology 64(10):S107 (2003)

  17. Regulation of Anti-Phosphatidylserine Antibodies

    Immunity 18(2):185 (2003)

    The degree of heavy chain (H) editing, the types of Vκ editors, and the pattern of Jκ usage are correlated with a range of the affinity of anti-DNA. This range was determined by the number and location of arginine (R) residues in the VH. We, here, changed a key arginine residue in the VH of...
  18. Analysis of B cell receptor production and rearrangement. Part I. Light chain rearrangement.

    Seminars in Immunology 14(3):169 (2002) PMID 12160645

    A probabilistic model of allelic exclusion fails to explain the status of receptor genes and the receptor phenotype of most B cells. A large proportion of B cells have incompletely rearranged H and/or L chain genes (e.g. kappa0/kappa+) and most B cells express only one receptor. These properties...
  19. D is for different-differences between H and L chain rearrangement.

    Seminars in Immunology 14(3):239 (2002) PMID 12160656

  20. Analysis of B cell receptor production and rearrangement:Part I. Light chain rearrangement

    Seminars in Immunology 14(3):169 (2002)

    A probabilistic model of allelic exclusion fails to explain the status of receptor genes and the receptor phenotype of most B cells. A large proportion of B cells have incompletely rearranged H and/or L chain genes (e.g. κ0/ κ+) and most B cells express only one receptor. These...