1. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

    Cell 160(4):595 (2015) PMID 25640239

    Functional micropeptides can be concealed within RNAs that appear to be noncoding. We discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncoding RNA. MLN shares structural and functional similarity with p...
  2. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest

    Cell Reports 10(5):841 (2015)

  3. MyoR modulates cardiac conduction by repressing Gata4.

    Molecular and Cellular Biology 35(4):649 (2015) PMID 25487574 PMCID PMC4301724

    The cardiac conduction system coordinates electrical activation through a series of interconnected structures, including the atrioventricular node (AVN), the central connection point that delays impulse propagation to optimize cardiac performance. Although recent studies have uncovered important...
  4. Histone Deacetylase 7 (Hdac7) Suppresses Chondrocyte Proliferation and β-Catenin Activity during Endochondral Ossification.

    Journal of Biological Chemistry 290(1):118 (2015) PMID 25389289

    Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modulating cellular responses to growth factors and cytokines. We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation. In this study, we examined the role of Hd...
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  5. Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification.

    Journal of Biological Chemistry 290(1):118 (2015) PMID 25389289 PMCID PMC4281714

    Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modulating cellular responses to growth factors and cytokines. We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation. In this study, we examined the role of Hd...
  6. Histone Deacetylase 7 (Hdac7) Suppresses Chondrocyte Proliferation and β-Catenin Activity during Endochondral Ossification.

    Journal of Biological Chemistry 290(1):118 (2015) PMID 25389289 PMCID PMC4281714

    Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modulating cellular responses to growth factors and cytokines. We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation. In this study, we examined the role of Hd...
  7. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest

    Cell Reports 9(5):1885 (2014)

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is sur...
  8. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.

    Cell Reports 9(5):1885 (2014) PMID 25466249

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is surprisingly ...
  9. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.

    Cell Reports 9(5):1885 (2014) PMID 25466249 PMCID PMC4267159

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is surprisingly ...
  10. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.

    Cell Reports 9(5):1885 (2014) PMID 25466249

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is surprisingly ...
  11. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.

    Cell Reports 9(5):1885 (2014) PMID 25466249 PMCID PMC4267159

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is surprisingly ...
  12. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.

    Cell Reports 9(5):1885 (2014) PMID 25466249 PMCID PMC4267159

    Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality. Although Pax3 mutations produce profound phenotypes, the intrinsic transcriptional activation exhibited by Pax3 is surprisingly ...
  13. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.

    Embo Molecular Medicine 6(12):1610 (2014) PMID 25422356 PMCID PMC4287978

    The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to...
  14. A neonatal blueprint for cardiac regeneration.

    Stem Cell Research 13(3 Pt B):556 (2014) PMID 25108892

    Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Re...
  15. A neonatal blueprint for cardiac regeneration.

    Stem Cell Research 13(3 Pt B):556 (2014) PMID 25108892

    Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Re...
  16. A neonatal blueprint for cardiac regeneration.

    Stem Cell Research 13(3 Pt B):556 (2014) PMID 25108892

    Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Re...
  17. A neonatal blueprint for cardiac regeneration.

    Stem Cell Research 13(3 Pt B):556 (2014) PMID 25108892 PMCID PMC4316722

    Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Re...
  18. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.

    Development 141(22):4267 (2014) PMID 25344074

    Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atr...
  19. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.

    Development 141(22):4267 (2014) PMID 25344074 PMCID PMC4302916

    Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atr...
  20. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.

    Development 141(22):4267 (2014) PMID 25344074

    Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atr...