1. Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties.

    Journal of Virology 89(15):7829 (2015) PMID 25995260 PMCID PMC4505639

    HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup...
  2. Case 7-2015: A 25-Year-Old Man with Oral Ulcers, Rash, and Odynophagia

    New England Journal of Medicine 372(9):864 (2015)

    A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed. Presentation of Case ...
  3. Case 6-2015: A 16-Year-Old Boy with Coughing Spells

    New England Journal of Medicine 372(8):765 (2015)

    A 16-year-old boy presented with a 3-week history of cough and nasal congestion and a 3-day history of severe coughing spells, post-tussive emesis, and trouble breathing. A chest radiograph was normal. A diagnostic test was performed. Presentation of Case Dr. Mark A...
  4. Case 4-2015: A 49-Year-Old Man with Obtundation Followed by Agitation and Acidosis

    New England Journal of Medicine 372(5):465 (2015)

    A 49-year-old man was admitted to this hospital after being found unresponsive outdoors; he was next to a half-filled bottle of cloudy liquid with pill fragments. An electrocardiogram showed a QTc interval of 501 msec. A diagnostic test was performed. Presentation of Case ...
  5. Case 39-2014: A 9-Year-Old Girl with Crohn’s Disease and Pulmonary Nodules

    New England Journal of Medicine 371(25):2418 (2014)

    A 9-year-old girl with Crohn's disease was admitted to this hospital because of abdominal pain and diarrhea. Abdominal imaging showed pulmonary nodules, some with necrotic centers. A diagnostic procedure was performed. Presentation of Case Dr. Michelle K. Trivedi (P...
  6. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards.

    Clinical Transplantation 28(12):1416 (2014) PMID 25303316

    Infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that d...
  7. High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.

    Open forum infectious diseases 1(3):ofu108 (2014) PMID 25734176 PMCID PMC4324225

    Individuals infected with human immunodeficiency virus (HIV) have decreased high-density lipoprotein (HDL)-cholesterol and increased cardiovascular disease (CVD). Reverse cholesterol transport from macrophages may be inhibited by HIV and contribute to increased CVD. Human studies have not invest...
  8. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards.

    Clinical Transplantation 28(12):1416 (2014) PMID 25303316 PMCID PMC4481866

    Infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that d...
  9. High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.

    Open forum infectious diseases 1(3):ofu108 (2014) PMID 25734176 PMCID PMC4324225

    Individuals infected with human immunodeficiency virus (HIV) have decreased high-density lipoprotein (HDL)-cholesterol and increased cardiovascular disease (CVD). Reverse cholesterol transport from macrophages may be inhibited by HIV and contribute to increased CVD. Human studies have not invest...
  10. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards.

    Clinical Transplantation 28(12):1416 (2014) PMID 25303316

    Infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that d...
  11. Case 37-2014: A 35-Year-Old Woman with Suspected Mite Infestation

    New England Journal of Medicine 371(22):2115 (2014)

    A 35-year-old woman with a history of drug dependency was seen in the emergency department because of a rash that was thought to be due to mite infestation. She reported seeing bugs on her skin. Examination revealed excoriations on her skin, but the midback was spared. Presen...
  12. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

    Journal of Virology 88(21):12793 (2014) PMID 25165102 PMCID PMC4248916

    Events during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell respons...
  13. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

    Journal of Virology 88(21):12793 (2014) PMID 25165102

    Events during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell respons...
  14. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

    Journal of Virology 88(21):12793 (2014) PMID 25165102 PMCID PMC4248916

    Events during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell respons...
  15. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.

    Journal of Virology 88(21):12793 (2014) PMID 25165102 PMCID PMC4248916

    Events during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell respons...
  16. Case 34-2014: A 7-Year-Old Boy with Focal Seizures and Progressive Weakness

    New England Journal of Medicine 371(18):1737 (2014)

    A 7-year-old boy was evaluated because of focal seizures, twitching of the right arm and the right side of the face, and progressive weakness. Imaging revealed progressive left cortical atrophy and a focal lesion in the left parietal cortex. A diagnostic procedure was performed. ...
  17. Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection.

    Journal of Infectious Diseases 210(7):1042 (2014) PMID 24688071 PMCID PMC4215080

    Inflammation in early human immunodeficiency virus type 1 (HIV-1) disease progression is not well characterized. Ninety patients with untreated primary HIV-1 infection were studied to determine associations of inflammatory proteins with early disease progression. High plasma tumor necrosis facto...
  18. Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection.

    Journal of Infectious Diseases 210(7):1042 (2014) PMID 24688071 PMCID PMC4215080

    Inflammation in early human immunodeficiency virus type 1 (HIV-1) disease progression is not well characterized. Ninety patients with untreated primary HIV-1 infection were studied to determine associations of inflammatory proteins with early disease progression. High plasma tumor necrosis facto...
  19. Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection.

    Journal of Infectious Diseases 210(7):1042 (2014) PMID 24688071 PMCID PMC4215080

    Inflammation in early human immunodeficiency virus type 1 (HIV-1) disease progression is not well characterized. Ninety patients with untreated primary HIV-1 infection were studied to determine associations of inflammatory proteins with early disease progression. High plasma tumor necrosis facto...
  20. Increased frequency and function of KIR2DL1-3⁺ NK cells in primary HIV-1 infection are determined by HLA-C group haplotypes.

    European Journal of Immunology 44(10):2938 (2014) PMID 25043727 PMCID PMC4197106

    The acquisition and maintenance of NK-cell function is mediated by inhibitory killer-cell immunoglobulin-like receptors (KIRs) through their interaction with HLA class I molecules. Recently, HLA-C expression levels were shown to be correlated with protection against multiple outcomes of HIV-1 in...