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  1. Systems biology approaches in identifying the targets of natural compounds for cancer therapy.

    Current Drug Discovery Technologies 10(2):139 (2013) PMID 23237676

    We will briefly introduce the several systems biology approaches, and will discuss the application of these new technologies for identifying the therapeutic targets of natural compounds for supporting their roles in the prevention and/or treatment of human cancers. Furthermore, identification of the...
  2. miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer.

    Cancer Discovery 2(6):489 (2012) PMID 22684455 PMCID PMC3375870

    Jahid and colleagues have shown that miR-23a promotes the transition from indolent to invasive colorectal cancer through inhibition of the MTSS1 tumor suppressor. This study reveals a novel role of miR-23a in the acceleration of colorectal cancer progression.
  3. The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis.

    International Journal of Molecular Sciences 13(10):13414 (2012) PMID 23202960 PMCID PMC3497334

    We will provide an overview and update of our current understanding of the mode of action of several of these well characterized miRNAs in breast cancer models. Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards...
  4. Emerging roles of PDGF-D signaling pathway in tumor development and progression

    Biochimica et Biophysica Acta (BBA) - Reviews o... 1806(1):122 (2010) PMID 20434526 PMCID PMC2885511

    We summarize data on several PDGF-D inhibitors especially naturally occurring “chemopreventive agent” such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling....
  5. Exploitation of the Notch signaling pathway as a novel target for cancer therapy.

    Anticancer Research 28(6A):3621 (2008) PMID 19189643

    The Notch signaling pathway appears to be responsible for maintaining a balance between cell proliferation and apoptosis and thus it has been suggested that Notch may play an important role in species development and in the development and progression of several malignancies. Therefore, the Notch si...
  6. Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancrea...

    Pancreas 31(4):317 (2005) PMID 16258364

    We have previously shown that genistein, a prominent soy isoflavone, transcriptionally down-regulates Bcl-2, Bcl-XL, VEGF, MMP-9, and uPAR via inhibiting NF-kappaB activity. In this study, genistein down-regulated NF-kappaB DNA binding activity and inhibited the growth of BxPC-3 pancreatic cancer ce...
  7. Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines.

    Molecular Cancer Therapeutics 3(11):1421 (2004) PMID 15542781

    We conclude that celecoxib potentiates gemcitabine-induced growth inhibition and apoptosis in pancreatic cell lines. In addition to inhibition of the COX-2 enzyme, the celecoxib and gemcitabine combination down-regulated nuclear factor-kappaB activation, which in turn may have contributed to the ind...
  8. Effects of lycopene supplementation in patients with localized prostate cancer.

    Experimental Biology and Medicine 227(10):881 (2002) PMID 12424329

    We conducted a clinical trial to investigate the biological and clinical effects of lycopene supplementation in patients with localized prostate cancer. Twenty-six men with newly diagnosed prostate cancer were randomly assigned to receive a tomato oleoresin extract containing 30 mg of lycopene (n =...
  9. Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells.

    Molecular Carcinogenesis 34(2):91 (2002) PMID 12112315

    We investigated the effects of genistein on androgen-mediated and estrogen-mediated transcriptional regulation of PSA, androgen receptor (AR) mRNA and protein expression, and the ability of nuclear proteins to bind to androgen-response elements (AREs) in LNCaP cells. We showed that genistein decreas...
  10. Pancreatic Cancer Stem-like Cells Display Aggressive Behavior Mediated via Activation of FoxQ1.

    Journal of Biological Chemistry 289(21):14520 (2014) PMID 24719318 PMCID PMC4031510

    We found that isolated triple-marker-positive (CD44(+)/CD133(+)/EpCAM(+)) cells of human PC MiaPaCa-2 and L3.6pl cells behave as CSLCs. These CSLCs exhibit aggressive behavior, such as increased cell growth, migration, clonogenicity, and self-renewal capacity. The mRNA expression profiling analysis...