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  1. Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.

    Cancer Letters 351(1):134 (2014) PMID 24839931 PMCID PMC4115205

    Aberrant expression of microRNAs (miRNAs) plays important roles in the development and progression of pancreatic cancer (PC). Expression analysis of miR-146a in human PC tissues showed decreased expression in about 80% of samples compared to corresponding non-cancerous tissue. Moreover, expression o...
  2. Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells.

    Cancer Letters 307(1):26 (2011) PMID 21463919 PMCID PMC3104092

    We show that forced over-expression of Notch-1 leads to increased cell growth, clonogenicity, migration and invasion of AsPC-1 cells. Moreover, over-expression of Notch-1 led to the induction of EMT phenotype by activation of mesenchymal cell markers such as ZEB1, CD44, EpCAM, and Hes-1. Here we als...
  3. Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.

    Bioorganic & Medicinal Chemistry Letters 20(19):5818 (2010) PMID 20729081

    We have attempted to overcome these limitations in case of 2'-hydroxychalcones through bioisosteric substitution of fluoro groups in place of phenolic hydroxyls. The fluorinated chalcones were found to be more potent antioxidant and anti-proliferative compounds than their hydroxyl counterparts indic...
  4. MDM2 inhibitors for pancreatic cancer therapy.

    Mini-Reviews in Medicinal Chemistry 10(6):518 (2010) PMID 20377522

    Our laboratory has been at the forefront in testing MDM2 inhibitors in pancreatic adenocarcinoma (PaCa), a deadly disease with approximately 50% wild-type p53 population. Emerging evidence suggests that apart from regulating p53, MDM2 can influence other key molecules involved in cancer. This review...
  5. Hybrid anticancer agents: isothiocyanate-progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicities.

    Bioorganic & Medicinal Chemistry Letters 20(3):1247 (2010) PMID 20022750

    Our results underscore the possible role of metal redox cycling, and thus it is likely will open newer avenues for further optimization for the synthesis of novel active compounds through appropriate isothiocyanate pharmacophores. Published by Elsevier Ltd....
  6. New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in...

    Pharmaceutical Research 26(8):1874 (2009) PMID 19421843 PMCID PMC3792798

    We have designed and synthesized new difluoro Knoevenagel condensates of curcumin and Schiff bases along with their copper (II) complexes and evaluated their biological activities with respect to the inhibitory effects on purified rabbit 26S proteasome, and growth inhibition and induction of apoptos...
  7. Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

    Journal of Hematology & Oncology 2:38 (2009) PMID 19725977 PMCID PMC2743703

    We have summarized the progress of our current research knowledge on garcinol and its observed biological activities. We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of...
  8. c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer...

    Clinical Cancer Research 13(9):2811 (2007) PMID 17473215

    We investigated the value of c-myc as a potential modulator of cellular response to various chemotherapeutic agents. Stable overexpression or small interfering RNA (siRNA)-mediated knockdown of c-myc and restoration of cyclin D1 were done in the Ela-myc pancreatic tumor cell line. Cell viability aft...
  9. Ciprofloxacin inhibits cell growth and synergises the effect of etoposide in hormone resistant prostate cancer cells.

    International Journal of Oncology 21(1):207 (2002) PMID 12063570

    We studied the effect of ciprofloxacin on a hormone resistant prostate cancer (HRPC) cell line, PC-3. Our study shows significant in vitro cell growth inhibition of PC-3 cell line (p=0.0001) and also shows that there is a synergistic increase in the antiproliferative effect of etoposide when these c...
  10. Pharmacokinetic comparison of leukocyte andEscherichia coli-derived human interferon type alpha

    Antiviral Research 2(1):103 (1982)

    Human alpha interferons derived from leukocytes (HuIFN-α-Le) and from an Escherichia coli clone (HuIFN- α 1) were compared for their relative abilities to distribute systemically in mice following intramuscular or intraperitoneal injections, and for their rate of clearance fr...