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  1. Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancer.

    Colloids and Surfaces B: Biointerfaces 132:138 (2015) PMID 26037703

    Pancreatic cancer remains one of the most devastating diseases in terms of patient mortality rates for which current treatment options are very limited. 3,4-Difluorobenzylidene curcumin (CDF) is a nontoxic analog of curcumin (CMN) developed in our laboratory, which exhibits extended circulation ...
  2. miR-20b is up-regulated in brain metastases from primary breast cancers.

    Oncotarget 6(14):12188 (2015) PMID 25893380 PMCID PMC4494931

    Brain metastases are frequent in patients with advanced breast cancer and are associated with poor prognosis. However, unique molecular biomarkers have not yet been established. We hypothesized that microRNA-20b (miR-20b) plays a role in breast cancer brain metastasis. Our study cohort comprised...
  3. Erratum to: Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicity.

    Biological Trace Element Research 164(1):162 (2015) PMID 25488703

  4. Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes.

    Prostate 75(2):161 (2015) PMID 25307492 PMCID PMC4270852

    The mechanism(s) by which androgen receptor (AR) splice variants contribute to castration-resistant prostate cancer (CRPC) is still lacking. Expressions of epithelial-to-mesenchymal transition (EMT) and stem cell markers were molecularly tested using prostate cancer (PCa) cells transfected with ...
  5. Molecular targets of naturopathy in cancer research: bridge to modern medicine.

    Nutrients 7(1):321 (2015) PMID 25569626 PMCID PMC4303842

    The relevance of naturopathy (defined as the practice of medicine for the treatment of human diseases with natural agents) in human cancer is beginning to be appreciated, as documented by renewed interest in nutraceutical research, the natural anticancer agents of dietary origin. Because of thei...
  6. Overview on the complexity of androgen receptor-targeted therapy for prostate cancer.

    Cancer Cell International 15:7 (2015) PMID 25705125 PMCID PMC4336517

    In the past decades, the field of prostate cancer (PCa) biology has developed exponentially and paralleled with that has been the growing interest in translation of laboratory findings into clinical practice. Based on overwhelming evidence of high impact research findings which support the under...
  7. Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1.

    Journal of Translational Medicine 13:227 (2015) PMID 26174772 PMCID PMC4501087

    There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic approaches. A primary meningioma cell line was generated from a patient with an olfactory ...
  8. Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4.

    BMC Cancer 15:540 (2015) PMID 26206152 PMCID PMC4512090

    For breast cancer patients diagnosed with estrogen receptor (ER)-positive tumors, treatment with tamoxifen is the gold standard. A significant number of patients, however, develop resistance to tamoxifen, and management of such tamoxifen-resistant patients is a major clinical challenge. With an ...
  9. Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cells.

    American journal of cancer research 5(3):1251 (2015) PMID 26046003 PMCID PMC4449452

    Understanding of molecular events associated with tumor microenvironment in pancreatic cancer (PC) is an active area of research especially because of the rich desmoplasia seen in human PC. Desmoplasia is contributed by several cell types including cancer-associated fibroblast (CAF) and stellate...
  10. Recent progress on nutraceutical research in prostate cancer.

    Cancer and Metastasis Reviews 33(2-3):629 (2014) PMID 24375392 PMCID PMC4074449

    Recently, nutraceuticals have received increasing attention as the agents for cancer prevention and supplement with conventional therapy. Prostate cancer (PCa) is the most frequently diagnosed cancer and second leading cause of cancer-related death in men in the US. Growing evidences from epidem...