Advanced search×
×
  1. DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.

    PNAS 110(46):18650 (2013) PMID 24127581 PMCID PMC3831962

    We report that administration of DIM in a multidose schedule protected rodents against lethal doses of total body irradiation up to 13 Gy, whether DIM dosing was initiated before or up to 24 h after radiation. Physiologic submicromolar concentrations of DIM protected cultured cells against radiation...
  2. Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implicati...

    Anti-Cancer Agents in Medicinal Chemistry 13(7):1002 (2013) PMID 23272910 PMCID PMC3901097

    We will review the available literature on the modulation of PI3K/Akt/mTOR/NF-κB signaling by both parental I3C and DIM, as well as their analogs/derivatives, in an attempt to catalog their anticancer activity....
  3. Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1α accumulation via increased production of reactive...

    PLoS ONE 8(7):e69485 (2013) PMID 23922721 PMCID PMC3726697

    Our results suggest that mitochondrial dysfunction promotes cancer cell motility partly through HIF1α accumulation mediated via increased production of reactive oxygen species....
  4. Clinical advances in molecular biomarkers for cancer diagnosis and therapy.

    International Journal of Molecular Sciences 14(7):14771 (2013) PMID 23863689 PMCID PMC3742272

    Cancer diagnosis is currently undergoing a paradigm shift with the incorporation of molecular biomarkers as part of routine diagnostic panel. The molecular alteration ranges from those involving the DNA, RNA, microRNAs (miRNAs) and proteins. The miRNAs are recently discovered small non-coding endoge...
  5. Forkhead box M1 transcription factor: a novel target for cancer therapy.

    Cancer Treatment Reviews 36(2):151 (2010) PMID 20022709 PMCID PMC2838950

    FoxM1 signaling has been reported to be associated with carcinogenesis. Therefore, the FoxM1 may represent a novel therapeutic target, and thus the development of agents that will target FoxM1 is likely to have significant therapeutic impact on human cancer. This review describes the mechanisms of s...
  6. Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.

    Cancer Research 69(15):6083 (2009) PMID 19622773 PMCID PMC2777684

    We show that DIM up-regulates expression of the tumor suppressor protein BRCA1 in carcinoma and normal cell types. Up-regulation of BRCA1 was dose and time dependent, and it was observed at physiologically relevant micromolar and submicromolar DIM concentrations when cells were exposed for 72 hours....
  7. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic ...

    Molecular Cancer Therapeutics 7(6):1708 (2008) PMID 18566242 PMCID PMC3770536

    We determined the effects of 3,3'-diindolylmethane (Bioresponse BR-DIM referred to as B-DIM), a formulated DIM with greater bioavailability on cell viability and apoptosis with erlotinib in vitro and in vivo using an orthotopic animal tumor model. BxPC-3 and MIAPaCa cells with varying levels of EGFR...
  8. Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.

    Stem Cells 26(6):1425 (2008) PMID 18403754 PMCID PMC3766351

    We established stably transfected PC3 cells expressing high levels of PDGF-D, which resulted in the significant induction of EMT as shown by changes in cellular morphology concomitant with the loss of E-cadherin and zonula occludens-1 and gain of vimentin. We also found activation of mammalian targe...
  9. In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer.

    International Journal of Cancer 120(4):906 (2007) PMID 17131310

    We recently reported the potential of genistein in augmenting gemcitabine-induced killing of pancreatic cancer (Banerjee, S. et al., Cancer Research 2005;65:9064-72). Since cis-diaminedichloroplatinum (II) (cisplatin) is widely used against solid tumors, we further investigated whether genistein pre...
  10. Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells.

    Breast Cancer Research and Treatment 90(1):25 (2005) PMID 15770523

    We investigated the interaction between flavopiridol and gemcitabine in two human breast cancer cell lines. Experimental design. MCF-7 [Estrogen receptor (ER) positive] and MDA-MB-231 cells (ER negative) were treated with sub-cytotoxic concentrations of gemcitabine (G), flavopiridol (F), and flavopi...