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  1. Genistein down-regulates miR-223 expression in pancreatic cancer cells.

    Current Drug Targets 14(10):1150 (2013) PMID 23834147

    We investigated whether a natural compound genistein could down-regulate onco-miR-223, resulting in the inhibition of cell growth and invasion, and induction of apoptosis in PC cells. We found that genistein treatment significantly inhibited miR-223 expression and up-regulated Fbw7, one of the targe...
  2. From body art to anticancer activities: perspectives on medicinal properties of henna.

    Current Drug Targets 13(14):1777 (2012) PMID 23140289

    We have summarized the chemistry and biological activities of Lawsone along with its analogs and metal complexes....
  3. Activation of AMP-Activated Protein Kinase by 3,3'-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and I...

    PLoS ONE 7(10):e47186 (2012) PMID 23056607 PMCID PMC3467201

    We previously reported that a formulated DIM (BR-DIM; hereafter referred as B-DIM) with higher bioavailability was able to induce apoptosis and inhibit cell growth, angiogenesis, and invasion of prostate cancer cells. However, the precise molecular mechanism(s) for the anti-cancer effects of B-DIM h...
  4. Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness.

    American journal of translational research 4(4):432 (2012) PMID 23145211 PMCID PMC3493023

    We investigated the cellular consequence of miR-34a over-expression and under-expression in the regulation of androgen receptor (AR) and Notch-1 in PCa cells. We found that over-expression of miR-34a led to reduced expression of AR, PSA and Notch-1. We also found that over-expression of miR-34a sign...
  5. Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.

    Oncotarget 2(5):378 (2011) PMID 21623005 PMCID PMC3248191

    We had shown that the MDM2 inhibitor (MI-219) belonging to the spiro-oxindole family can synergistically enhance the efficacy of platinum chemotherapeutics leading to 50% tumor free survival in a genetically complex pancreatic ductaladenocarcinoma (PDAC) xenograft model. In this report, we have take...
  6. Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

    Journal of Cellular Biochemistry 112(1):78 (2011) PMID 20658545 PMCID PMC3792569

    We investigated the cellular consequence of Notch-1 down-regulation and also assessed the molecular consequence of Notch-1-mediated alterations of its downstream targets on cell viability and apoptosis in prostate cancer (PCa) cells. We found that the down-regulation of Notch-1 led to the inhibition...
  7. MDM2 inhibitors for pancreatic cancer therapy.

    Mini-Reviews in Medicinal Chemistry 10(6):518 (2010) PMID 20377522

    Our laboratory has been at the forefront in testing MDM2 inhibitors in pancreatic adenocarcinoma (PaCa), a deadly disease with approximately 50% wild-type p53 population. Emerging evidence suggests that apart from regulating p53, MDM2 can influence other key molecules involved in cancer. This review...
  8. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its ana...

    Cancer Research 70(9):3606 (2010) PMID 20388782 PMCID PMC2978024

    We have previously evaluated the bioavailability of novel analogues of curcumin compared with curcumin, and we found that the analogue CDF exhibited greater systemic and pancreatic tissue bioavailability. In this study, we evaluated the effects of CDF or curcumin alone or in combination with gemcita...
  9. Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian canc...

    Cancer Biology & Therapy 5(5):523 (2006) PMID 16627977

    We studied loss of heterozygosity (LOH) and microsatellite instability (MSI) of microsatellite markers DXS15A, DXS1107, WI12360 and WI9327 for the Xq28 region in 29 ovarian cancer biopsies. The results showed that the LOH frequencies were 18.2%, 30%, 26.3% and 20.8% for WI12360, WI9327, DXS1107 and...
  10. Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein.

    Neoplasia 6(4):354 (2004) PMID 15256057 PMCID PMC1502110

    We investigated the effects of genistein on PC3 prostate cancer cells and experimental PC3 bone tumors created by injecting PC3 cells into human bone fragments previously implanted in severe combined immunodeficient (SCID) mice (SCID human model). We found that genistein significantly inhibited PC3...