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  1. Pancreatic Cancer Stem-like Cells Display Aggressive Behavior Mediated via Activation of FoxQ1.

    Journal of Biological Chemistry 289(21):14520 (2014) PMID 24719318 PMCID PMC4031510

    We found that isolated triple-marker-positive (CD44(+)/CD133(+)/EpCAM(+)) cells of human PC MiaPaCa-2 and L3.6pl cells behave as CSLCs. These CSLCs exhibit aggressive behavior, such as increased cell growth, migration, clonogenicity, and self-renewal capacity. The mRNA expression profiling analysis...
  2. Perspectives on the role of isoflavones in prostate cancer.

    AAPS Journal 15(4):991 (2013) PMID 23824838 PMCID PMC3787218

    Isoflavones have been investigated in detail for their role in the prevention and therapy of prostate cancer. This is primarily because of the overwhelming data connecting high dietary isoflavone intake with reduced risk of developing prostate cancer. A number of investigations have evaluated the me...
  3. Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through C...

    Journal of Translational Medicine 11:35 (2013) PMID 23394575 PMCID PMC3608954

    We reported that tumor spheres formed by breast cancer cell lines were visibly smaller in a Th1 enriched microenvironment with significantly reduced differentiation of MDSC populations in 3D culture. In this study, we investigated the mechanism(s) of bispecific antibody armed ATC mediated inhibition...
  4. Dietary agents in cancer chemoprevention and treatment.

    Journal of Oncology 2012:749310 (2012) PMID 23316231 PMCID PMC3536068

  5. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM).

    Pharmaceutical Research 25(9):2117 (2008) PMID 18427961 PMCID PMC3766320

    Cancer chemoprevention is defined as the use of natural, synthetic, or biological agents to suppress, reverse or prevent the carcinogenic process from turning into aggressive cancer. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in prostat...
  6. Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB.

    Journal of Ovarian Research 1(1):9 (2008) PMID 19025644 PMCID PMC2611983

    Platinum-resistance (PR) continues to be a major problem in the management of epithelial ovarian cancer (EOC). Response to various chemotherapeutic agents is poor in patients deemed PR. Genistein, a soy isoflavone has been shown to enhance the effect of chemotherapy in prostate and pancreatic cancer...
  7. Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.

    Cancer Research 67(11):5389 (2007) PMID 17545620

    We evaluated the therapeutic effectiveness of ERRP on early and intermediate stages of colon cancer by examining regression of chemically induced aberrant crypt foci (ACF) in the colon of CF1 mice and intestinal adenomas in APC(Min+/-) (Min) mice. After formation of ACF or adenomas, the mice were in...
  8. Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail.

    Nutrition and Cancer 50(2):181 (2004) PMID 15623465

    We investigated the effects of lycopene supplementation on the development of leiomyomas in the oviduct of Japanese quail. We also measured serum levels of oxidative stress markers [malondialdehyde (MDA) and homocysteine], lycopene, vitamins C, E, and A, and tissue biomarkers Bcl-2 and Bax expressio...
  9. The Story of What Can Go Wrong:Functional Endocrine Pathology. Second Edition, Edited by Kalman Kovacs and Sylvia Asa

    Trends in Endocrinology & Metabolism 10(7):290 (1999)

  10. Production of 13-Hydroxyoctadecadienoic Acid (13-HODE) by Prostate Tumors and Cell Lines

    Biochemical and Biophysical Research Communicat... 239(3):775 (1997) PMID 9367845

    We have used a polyclonal antibody specific for 13-( S)-HODE to detect this bioactive lipid for the first time in human prostate adenocarcinoma specimens (PCa) and the prostate cancer cell lines LNCaP and PC-3 by enzyme immunoassay. In addition, we have verified the quantitation of 13-HODE by...