1. Culture conditions profoundly impact phenotype in BEAS-2B, a human pulmonary epithelial model.

    Journal of Applied Toxicology 35(8):945 (2015) PMID 25524072 PMCID PMC4474793

    BEAS-2B, an immortalized, human lung epithelial cell line, has been used to model pulmonary epithelial function for over 30 years. The BEAS-2B phenotype can be modulated by culture conditions that include the presence or absence of fetal bovine serum (FBS). The popularity of BEAS-2B as a model o...
  2. Protective effects of vascular endothelial growth factor in cultured brain endothelial cells against hypoglycemia.

    Metabolic Brain Disease 30(4):999 (2015) PMID 25761767 PMCID PMC4491374

    Hypoglycemia is a common and serious problem among patients with type 1 diabetes receiving treatment with insulin. Clinical studies have demonstrated that hypoglycemic edema is involved in the initiation of hypoglycemic brain damage. However, the mechanisms of this edema are poorly understood. V...
  3. Pharmacokinetics of eupalinolide A, eupalinolide B and hyperoside from Eupatorium lindleyanum in rats by LC/MS/MS.

    Journal of Chromatography B 995-996:1 (2015) PMID 26011510

    A simple, selective, and sensitive LC/MS/MS method was developed and validated for simultaneous determination of eupalinolide A, eupalinolide B, and hyperoside in rat plasma. Plasma samples were processed by protein precipitation with acetonitrile. The three analytes, together with internal stan...
  4. Identification of the Protective Role of DJ-1 in Hypoglycemic Astrocyte Injury Using Proteomics.

    Journal of Proteome Research 14(7):2839 (2015) PMID 26057206

    As a common complication of glycemic control in patients with diabetes, hypoglycemia often leads to brain dysfunction or damage. To identify new mechanisms underlying hypoglycemic brain injury, we determined the difference of protein expression profiles in brains between hypoglycemic rats and sh...
  5. Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells.

    Journal of Virology 89(13):6792 (2015) PMID 25903338 PMCID PMC4468470

    Human cytomegalovirus (HCMV) infection of the developing fetus frequently results in major neural developmental damage. In previous studies, HCMV was shown to downregulate neural progenitor/stem cell (NPC) markers and induce abnormal differentiation. As Notch signaling plays a vital role in the ...
  6. Exploring the influence of culture on hearing help-seeking and hearing-aid uptake.

    International Journal of Audiology 54(7):435 (2015) PMID 25761498

    The purpose of this paper was to highlight the importance of cultural influence in understanding hearing-help seeking and hearing-aid uptake. Information on audiological services in different countries and 'theories related to cross-culture' is presented, followed by a general discussion. Twenty...
  7. Spontaneous formation of Cu2O-g-C3N4 core-shell nanowires for photocurrent and humidity responses.

    Nanoscale 7(21):9694 (2015) PMID 25958952

    The assembly of low dimensional g-C3N4 structures in a geometrically well-defined fashion and the complexation of g-C3N4 with other materials are the main approaches to construct fancy structures for special functions. While high temperature was often indispensable for the preparation process, t...
  8. Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: Evidence from resting-state fMRI

    Progress in Neuro-Psychopharmacology and Biolog... 59:91 (2015)

    Numerous studies have shown that neurological changes are important findings of tinnitus patients. Previous studies on tinnitus have indicated that patients with pulsatile tinnitus (PT) often show altered baseline brain activity in the resting state. This study used resting-state funct...
  9. Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: Evidence from resting-state fMRI.

    Progress in Neuro-Psychopharmacology and Biolog... 59:91 (2015) PMID 25645870

    Numerous studies have shown that neurological changes are important findings of tinnitus patients. Previous studies on tinnitus have indicated that patients with pulsatile tinnitus (PT) often show altered baseline brain activity in the resting state. This study used resting-state functional magn...
  10. Induction of DNA base damage and strand breaks in peripheral erythrocytes and the underlying mechanism in goldfish (Carassius auratus) exposed to monocrotophos.

    Fish Physiology and Biochemistry 41(3):613 (2015) PMID 25666866

    Using goldfish (Carassius auratus) as the model animal, the present study revealed the types of the DNA damage induced by monocrotophos, a highly toxic organophosphorus pesticide, and explored the mechanism underlying the DNA-damaging effect of this pesticide. Results of the alkaline comet assay...
  11. MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase.

    International Journal of Molecular Medicine 35(6):1708 (2015) PMID 25872580

    A variety of microRNAs (miRNAs) have been reported to be significantly be involved in the regulation of vascular smooth muscle cell (VSMC) proliferation, which is an essential process for the formation of atherosclerotic plaque. The objective of the present study was to explore the role of micro...
  12. Intensity-modulated radiotherapy and volumetric-modulated arc therapy have distinct clinical advantages in non-small cell lung cancer treatment.

    Medical Oncology 32(4):546 (2015) PMID 25725813

    This study was conducted to compare the efficacy of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in delivering the planned dosage in the treatment of non-small cell lung cancer (NSCLC). Between September 2013 and March 2014, 125 NSCLC patients were randomly...
  13. Intensity-modulated radiotherapy and volumetric-modulated arc therapy have distinct clinical advantages in non-small cell lung cancer treatment.

    Medical Oncology 32(4):94 (2015) PMID 25725813

    This study was conducted to compare the efficacy of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in delivering the planned dosage in the treatment of non-small cell lung cancer (NSCLC). Between September 2013 and March 2014, 125 NSCLC patients were randomly...
  14. F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.

    Biochemical and Biophysical Research Communicat... 458(4):941 (2015) PMID 25721664

    It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and ...
  15. F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.

    Biochemical and Biophysical Research Communicat... 458(4):941 (2015) PMID 25721664

    It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and ...
  16. Incidence of Vascular Anomalies and Variants Associated with Unilateral Venous Pulsatile Tinnitus in 242 Patients Based on Dual-phase Contrast-enhanced Computed Tomography.

    Chinese Medical Journal 128(5):581 (2015) PMID 25698187

    A comprehensive assessment of various vascular anomalies and variants associated with venous pulsatile tinnitus (PT) by radiography is essential for therapeutic planning and improving the clinical outcome. This study evaluated the incidence of various vascular anomalies and variants on the PT si...
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  17. Ni3Mo 3C as Anode Catalyst for High-Performance Microbial Fuel Cells.

    Applied Biochemistry and Biotechnology 175(5):2637 (2015) PMID 25547817

    Ni3Mo3C was prepared by a modified organic colloid method and explored as anode catalyst for high-performance microbial fuel cell (MFC) based on Klebsiella pneumoniae (K. pneumoniae). The prepared sample was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), and Brunau...
  18. The outcome of the proximal radial artery arteriovenous fistula

    Journal of Vascular Surgery 61(3):802 (2015)

    Background Guidelines recommend placing native arteriovenous fistulas (AVFs) as far distally in the upper extremity as possible. If there are adequate veins and adequate arteries, a wrist fistula, which offers notably lower risks than grafts and catheters, would be the first ...
  19. The Therapeutic Potential of Rho Kinase Inhibitor Fasudil Derivative FaD-1 in Experimental Autoimmune Encephalomyelitis.

    Journal of Molecular Neuroscience 55(3):725 (2015) PMID 25223373

    Although therapeutic potential of fasudil in EAE is promising, action mechanism and clinical limitations are still not fully understood and resolved. In this study, we observed the therapeutic potential of a novel Rho kinase (ROCK) inhibitor FaD-1, a fasudil derivative, and explored possible mec...
  20. Transjugular intrahepatic portosystemic shunt for severe jaundice in patients with acute Budd-Chiari syndrome.

    World Journal of Gastroenterology 21(8):2413 (2015) PMID 25741149 PMCID PMC4342918

    To evaluate the feasibility of transjugular intrahepatic portosystemic shunt (TIPS) for severe jaundice secondary to acute Budd-Chiari syndrome (BCS). From February 2009 to March 2013, 37 patients with severe jaundice secondary to acute BCS were treated. Sixteen patients without hepatic venule, ...