1.  Insulin treatment of people with diabetes mellitus and chronic liver disease.

    Annals of Hepatology 15(2):287 (2016) PMID 26845609

  2. Effects of Aerobic Exercise Based upon Heart Rate at Aerobic Threshold in Obese Elderly Subjects with Type 2 Diabetes.

    International Journal of Endocrinology 2015:695297 (2015) PMID 26089890 PMCID PMC4452101

    In obese diabetic subjects, a correct life style, including diet and physical activity, is part of a correct intervention protocol. Thus, the aim of this study was to evaluate the effects of aerobic training intervention, based on heart rate at aerobic gas exchange threshold (AerTge), on clinica...
  3. Changes in stress hormones and metabolism during a 105-day simulated Mars mission.

    Aviation, Space, and Environmental Medicine 85(8):793 (2014) PMID 25199119

    The Mars-105 project was aimed at simulating crew's activities, workload, and communication during a mission to Mars, evaluating the homeostatic adaptations to prolonged confinement and cohabitation. Fasting plasma glucose (FPG) and insulin, C-peptide, leptin, cortisol, and NGF and BDNF plasma l...
  4. Application of technology in endocrine disease.

    International Journal of Endocrinology 2014:715029 (2014) PMID 24688544 PMCID PMC3945073

  5. Deficits in visuo-spatial but not in topographical memory during pregnancy and the postpartum state in an expert military pilot: a case report.

    BMC Research Notes 7:524 (2014) PMID 25115346 PMCID PMC4138368

    It is well known that cognitive and emotional changes occur during pregnancy, but little is known about their magnitude or their time of occurrence and recovery. During pregnancy memory is one of the most impaired cognitive functions. Although long-term aspects of memory have been investigated, ...
  6. Different prevalence of metabolic control and chronic complication rate according to the time of referral to a diabetes care unit in the elderly.

    Acta Diabetologica 51(3):447 (2014) PMID 24366424

    The time of diagnosis is crucial for type 2 diabetes mellitus (T2DM) in terms of disease severity and chronic complications, as initial glycated haemoglobin (HbA1c) predicts 5-year cardiovascular mortality. The Italian health-care system relies on about 650 diabetes care units (DCU) interfacing ...
  7. Mental rotation task in a pilot during and after pregnancy.

    Aviation, Space, and Environmental Medicine 84(10):1092 (2013) PMID 24261064

    Discordant findings have been reported about the change in pregnant women's cognitive test performance. Visuo-spatial abilities, which are crucial in terrestrial/flight navigation, could be influenced by hormonal variations. A 32-yr-old Italian Air Force pilot underwent a 2-D Mental Rotation Tas...
  8. Low-intermediate dose testosterone replacement therapy by different pharmaceutical preparations improves frailty score in elderly hypogonadal hyperglycaemic patients.

    The Aging Male 16(2):33 (2013) PMID 23517433

    An open-label follow-up study of low-to-intermediate dose testosterone replacement therapy (TRT) was conducted in 64 overweight patients (aged 65-75 years) with late onset hypogonadism (LOH) and increased fasting plasma glucose (FPG). Patients were subdivided into four treatment groups: oral tes...
  9. Sleep apnea, sleep disturbance, and fasting glucose variability: a pilot study.

    Journal of diabetes science and technology (Onl... 7(3):743 (2013) PMID 23759408 PMCID PMC3869143

    Disturbed sleep and nocturnal altered breathing are related to disturbances of glucose metabolism. The present uncontrolled observational study explores the role of these factors on the variability of fasting glycemia. The number and duration of nocturnal awakenings and the fasting glycemia of 9...
  10. Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy.

    Journal of Clinical Endocrinology & Metabolism 97(10):3467 (2012) PMID 22767639

    Cushing's syndrome may remain unrecognized among patients referred for metabolic syndrome; thus, a proactive screening has been suggested in certain patient populations with features of the disorder. However, conflicting data have been reported on the prevalence of Cushing's syndrome in patients...
  11. Frailty and safety: the example of diabetes.

    Drug Safety 35 Suppl 1:63 (2012) PMID 23446787

    Frailty is considered a syndrome of decreased reserve and resistance to stressors and is clinically expressed as muscle weakness, poor exercise tolerance, factors related to body composition, sarcopenia and disability. In addition, there is a close relationship between age-related metabolic chan...
  12. The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis.

    PLoS ONE 7(4):e35418 (2012) PMID 22558148 PMCID PMC3338839

    Hormonal changes in humans during spaceflight have been demonstrated but the underlying mechanisms are still unknown. To clarify this point thyroid and testis/epididymis, both regulated by anterior pituitary gland, have been analyzed on long-term space-exposed male C57BL/10 mice, either wild typ...
  13. Metabolic syndrome, adipokines and hormonal factors in pharmacologically untreated adult elderly subjects from the Brisighella Heart Study historical cohort.

    Obesity Facts 5(3):319 (2012) PMID 22722758

    Our aim was to evaluate the relation of the sex hormone pattern and the serum level of the main adipokines with metabolic syndrome (MS) and its components in a cohort of pharmacologically untreated adult elderly subjects. From the historical cohort of the Brisighella Heart Study we selected 199 ...
  14. Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes.

    Acta Diabetologica 48(2):121 (2011) PMID 20091324

    Only few insulin-treated (IT) people with diabetes mellitus (DM) reach the target due to poor compliance and/or to sedentary lifestyle and/or to inadequate treatment regimen. The latter may be also brought about by often overlooked factors including insulin injection into altered skin areas, oft...
  15. Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from the brisighella heart study.

    International Journal of Endocrinology 2011:724816 (2011) PMID 22114592 PMCID PMC3216320

    We evaluated the association of the sex hormone pattern and the serum level of the main adipokines to metabolic syndrome (MS) and its components in 199 pharmacologically untreated subjects. Men and women included in the age-class subgroups were matched for body mass index, waist circumference, b...
  16. Feeding behavior in mammals including humans.

    Annals of the Lyceum of Natural History of New ... 1163:221 (2009) PMID 19456343

    The complex control of food intake and energy metabolism in mammals relies on the ability of the brain to integrate multiple signals indicating the nutritional state and the energy level of the organism and to produce appropriate responses in terms of food intake, energy expenditure, and metabol...
  17. Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest.

    American Journal of Clinical Nutrition 88(4):950 (2008) PMID 18842781

    Physical inactivity is often associated with positive energy balance and fat gain. We aimed to assess whether energy intake in excess of requirement activates systemic inflammation and antioxidant defenses and accelerates muscle atrophy induced by inactivity. Nineteen healthy male volunteers wer...
  18. Low gravity and integrins in cultured glial cells

    Acta Astronautica 63(7):899 (2008)

    We studied the effect of random rotation on the expression of integrins in cultured astrocytes with or without the addition of divalent ions. Some cultures were immediately fixed, others were let to rest and then fixed. Cells were submitted to immunohistochemistry using antibodies to ...
  19. Effect of conditions of three dimensional clinostating on testicular cell machinery

    Acta Astronautica 60(4):391 (2007)

    Our scope was to study the effects of on ground random positioning machine rotation on swine testicular cells in culture. Cells of the 2 n karyotype line, from trypsinized swine testes, were submitted to modeled microgravity ( μ G ...
  20. Consensus Document on substitution therapy with DHEA in the elderly.

    Aging Clinical and Experimental Research 18(4):277 (2006) PMID 17063063