1. Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

    American Journal of Roentgenology 203(3):W280 (2014) PMID 25148185

    The purpose of this study was to prospectively evaluate the value of diffusion-weighted MRI (DWI) for the assessment of extracapsular extension (ECE) in patients with prostate cancer. Between November 2010 and April 2012, 40 patients with intermediate- to high-risk prostate cancer were prospecti...
  2. Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

    American Journal of Roentgenology 203(3):W280 (2014) PMID 25148185

    The purpose of this study was to prospectively evaluate the value of diffusion-weighted MRI (DWI) for the assessment of extracapsular extension (ECE) in patients with prostate cancer. Between November 2010 and April 2012, 40 patients with intermediate- to high-risk prostate cancer were prospecti...
  3. Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

    American Journal of Roentgenology 203(3):W280 (2014) PMID 25148185

    The purpose of this study was to prospectively evaluate the value of diffusion-weighted MRI (DWI) for the assessment of extracapsular extension (ECE) in patients with prostate cancer. Between November 2010 and April 2012, 40 patients with intermediate- to high-risk prostate cancer were prospecti...
  4. Prostate cancer: performance characteristics of combined T₂W and DW-MRI scoring in the setting of template transperineal re-biopsy using MR-TRUS fusion.

    European Radiology 24(7):1497 (2014) PMID 24744197

    To measure the performance characteristics of combined T2-weighted (T₂W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) suspicion scoring prior to MR-transrectal ultrasound (TRUS) fusion template transperineal (TTP) re-biopsy. Thirty-nine patients referred for prostate re-biopsy, w...
  5. Prostate cancer: performance characteristics of combined T₂W and DW-MRI scoring in the setting of template transperineal re-biopsy using MR-TRUS fusion.

    European Radiology 24(7):1497 (2014) PMID 24744197

    To measure the performance characteristics of combined T2-weighted (T₂W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) suspicion scoring prior to MR-transrectal ultrasound (TRUS) fusion template transperineal (TTP) re-biopsy. Thirty-nine patients referred for prostate re-biopsy, w...
  6. Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

    PNAS 109(33):13374 (2012) PMID 22837393 PMCID PMC3421192

    Acute kidney injury (AKI) is a common and important medical problem, affecting 10% of hospitalized patients, and it is associated with significant morbidity and mortality. The most frequent cause of AKI is acute tubular necrosis (ATN). Current imaging techniques and biomarkers do not allow ATN t...
  7. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    PLoS Genetics 8(11):e1003022 (2012) PMID 23166506 PMCID PMC3499256

    Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been associated with primary microcephaly and the microcephalic primordial dwarfism disorder Seckel syndrome. The mechanism by which disruptio...
  8. Imaging pH with hyperpolarized 13C.

    NMR in Biomedicine 24(8):1006 (2011) PMID 21812047

    pH is a fundamental physiological parameter that is tightly controlled by endogenous buffers. The acid-base balance is altered in many disease states, such as inflammation, ischemia and cancer. Despite the importance of pH, there are currently no routine methods for imaging the spatial distribut...
  9. Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

    Journal of nuclear medicine : official publicat... 52(9):1333 (2011) PMID 21849405

    Dynamic nuclear polarization (DNP) is an emerging technique for dramatically increasing the sensitivity of magnetic resonance spectroscopy (MRS). This review evaluates the potential strengths and weaknesses of DNP-enhanced (13)C magnetic resonance spectroscopic imaging (DNP-MRSI) as a clinical i...
  10. Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

    Journal of the American Chemical Society 133(30):11795 (2011) PMID 21692446 PMCID PMC3144679

    Dynamic nuclear polarization (DNP) of (13)C-labeled metabolic substrates in vitro and their subsequent intravenous administration allow both the location of the hyperpolarized substrate and the dynamics of its subsequent conversion into other metabolic products to be detected in vivo. We report ...
  11. Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.

    Magnetic Resonance in Medicine 66(2):505 (2011) PMID 21661043

    Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of magnetic resonance imaging and spectroscopy, particularly for low-γ nuclei. The technique has been applied recently to a number of 13C-labeled cell metabolites in biological systems: the increase in signal-to...
  12. Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.

    Magnetic Resonance in Medicine 66(1):18 (2011) PMID 21695718

    Dynamic nuclear polarization can be used to increase the sensitivity of solution state (13)C magnetic resonance spectroscopy by four orders of magnitude. We show here that [1-(13)C]glutamate can be polarized to 28%, representing a 35,000-fold increase in its sensitivity to detection at 9.4 T and...
  13. Functional and molecular imaging with MRI: potential applications in paediatric radiology.

    Pediatric Radiology 41(2):185 (2011) PMID 20972674

    MRI is a very versatile tool for noninvasive imaging and it is particularly attractive as an imaging technique in paediatric patients given the absence of ionizing radiation. Recent advances in the field of MRI have enabled tissue function to be probed noninvasively, and increasingly MRI is bein...
  14. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  15. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  16. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  17. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  18. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  19. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...
  20. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

    Molecular Cancer Therapeutics 9(12):3278 (2010) PMID 21159611 PMCID PMC3003424

    Nuclear spin hyperpolarization can dramatically increase the sensitivity of the (13)C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized (13)C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the v...